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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2500
Target Type SINGLE PROTEIN
Preferred Name Thiopurine S-methyltransferase
Synonyms TPMT | Thiopurine S-methyltransferase | Thiopurine methyltransferase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Thiopurine S-methyltransferase SINGLE PROTEIN P51580

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000137364
Ensembl ENSG00000137364
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0008119 (thiopurine S-methyltransferase activity)
GO:0008168 (methyltransferase activity)
GO:0008757 (S-adenosylmethionine-dependent methyltransferase activity)
GO:0016740 (transferase activity)
GO Biological Process GO:0006139 (nucleobase-containing compound metabolic process)
GO:0032259 (methylation)
Wikipedia Thiopurine_methyltransferase

Target Cross References - Protein

canSAR P51580
CGD Thiopurine S-methyltransferase deficiency
Human Protein Atlas ENSG00000137364
Open Targets ENSG00000137364
PharmGKB PA356
Reactome R-HSA-156581 (Methylation.)
UniProt O14806 O15423 O15424 O15425 O15426 O15515 O15548 O43213 P51580 Q5VUK6 Q9UBE6 Q9UBT8 Q9UE62

Target Cross References - Domain

InterPro IPR008854 (TPMT.)
IPR025835 (Thiopurine_S-MeTrfase.)
IPR029063 (SAM-dependent_MTases.)
Pfam PF05724 (TPMT)

Target Cross References - Structure

PDBe 2BZG 2H11
CREDO 2BZG 2H11
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