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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2494
Target Type SINGLE PROTEIN
Preferred Name CaM kinase IV
Synonyms CAMK | CAMK-GR | CAMK4 | CAMKIV | CaM kinase-GR | CaMK IV | Calcium/calmodulin-dependent protein kinase type IV
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > camk protein kinase group > camk protein kinase camk1 family

Target Components

Component Description Relationship Accession
Calcium/calmodulin-dependent protein kinase type IV SINGLE PROTEIN Q16566

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000152495
Ensembl ENSG00000152495
GO Cellular Component GO:0005654 (nucleoplasm)
GO:0005829 (cytosol)
GO Molecular Function GO:0004683 (calmodulin-dependent protein kinase activity)
GO:0005516 (calmodulin binding)
GO:0005524 (ATP binding)
GO Biological Process GO:0006468 (protein phosphorylation)
GO:0007202 (activation of phospholipase C activity)
GO:0007268 (synaptic transmission)
GO:0048011 (nerve growth factor receptor signaling pathway)
Wikipedia CAMK4

Target Cross References - Protein

canSAR Q16566
Human Protein Atlas ENSG00000152495
Guide to Pharmacology 1955 (calcium/calmodulin-dependent protein kinase IV)
PharmGKB PA26050
Reactome REACT_11061 (Signalling by NGF.)
REACT_13685 (Synaptic Transmission.)
REACT_15295 (Opioid Signalling.)
UniProt D3DSZ7 Q16566

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_cat_dom.)
IPR002290 (Ser/Thr_prot_kinase_dom.)
IPR008271 (Ser/Thr_prot_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR017442 (Se/Thr_prot_kinase-like_dom.)
Pfam PF00069 (Pkinase)

Target Cross References - Structure

PDBe 2W4O
CREDO 2W4O
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