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ChEMBL

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Target Report Card

Target Name and Classification

Target ID CHEMBL2493
Target Type SINGLE PROTEIN
Preferred Name CaM kinase I alpha
Synonyms CAMK1 | CaM kinase I alpha | CaM kinase I | CaM-KI | CaMKI-alpha | Calcium/calmodulin-dependent protein kinase type 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > camk protein kinase group > camk protein kinase camk1 family

Target Components

Component Description Relationship Accession
Calcium/calmodulin-dependent protein kinase type 1 SINGLE PROTEIN Q14012

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000134072
Ensembl ENSG00000134072
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0003824 (catalytic activity)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004683 (calmodulin-dependent protein kinase activity)
GO:0005515 (protein binding)
GO:0005516 (calmodulin binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO Biological Process GO:0006468 (protein phosphorylation)
GO:0006913 (nucleocytoplasmic transport)
GO:0007049 (cell cycle)
GO:0007165 (signal transduction)
GO:0007275 (multicellular organism development)
GO:0007399 (nervous system development)
GO:0008152 (metabolic process)
GO:0010976 (positive regulation of neuron projection development)
GO:0016310 (phosphorylation)
GO:0030154 (cell differentiation)
GO:0032091 (negative regulation of protein binding)
GO:0032880 (regulation of protein localization)
GO:0033138 (positive regulation of peptidyl-serine phosphorylation)
GO:0043393 (regulation of protein binding)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0046827 (positive regulation of protein export from nucleus)
GO:0051147 (regulation of muscle cell differentiation)
GO:0051149 (positive regulation of muscle cell differentiation)
GO:0051835 (positive regulation of synapse structural plasticity)
GO:0060143 (positive regulation of syncytium formation by plasma membrane fusion)
GO:0060999 (positive regulation of dendritic spine development)
GO:0071902 (positive regulation of protein serine/threonine kinase activity)
GO:1901985 (positive regulation of protein acetylation)
GO:2000615 (regulation of histone H3-K9 acetylation)
Wikipedia CAMK1

Target Cross References - Protein

canSAR Q14012
Human Protein Atlas ENSG00000134072
IntAct Q14012
Guide to Pharmacology 1952
Open Targets ENSG00000134072
PharmGKB PA26048
Pharos Q14012 (Tchem)
UniProt Q14012 Q3KPF6

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020636 (Ca/CaM-dep_Ca-dep_prot_Kinase.)
Pfam PF00069 (Pkinase)

Target Cross References - Structure

PDBe 4FG7 4FG8 4FG9 4FGB
CREDO 4FG7 4FG8 4FG9 4FGB
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