ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL2487
Target Type SINGLE PROTEIN
Preferred Name Beta amyloid A4 protein
Synonyms A4 | ABPP | AD1 | AICD-50 | AICD-57 | AICD-59 | AID(50) | AID(57) | AID(59) | APP | APP | APPI | Alzheimer disease amyloid protein | Amyloid beta A4 protein | Amyloid intracellular domain 50 | Amyloid intracellular domain 57 | Amyloid intracellular domain 59 | Beta-APP40 | Beta-APP42 | Beta-amyloid protein 40 | Beta-amyloid protein 42 | C31 | C80 | C83 | C99 | CVAP | Cerebral vascular amyloid peptide | Gamma-CTF(50) | Gamma-CTF(57) | Gamma-CTF(59) | Gamma-secretase C-terminal fragment 50 | Gamma-secretase C-terminal fragment 57 | Gamma-secretase C-terminal fragment 59 | N-APP | P3(40) | P3(42) | PN-II | PreA4 | Protease nexin-II | S-APP-alpha | S-APP-beta | Soluble APP-alpha | Soluble APP-beta
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor

Target Components

Component Description Relationship Accession
Amyloid beta A4 protein SINGLE PROTEIN P05067

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000142192
Ensembl ENSG00000142192
GO Cellular Component GO:0005576 (extracellular region)
GO:0005794 (Golgi apparatus)
GO:0005887 (integral to plasma membrane)
GO:0005905 (coated pit)
GO:0009986 (cell surface)
GO:0030424 (axon)
GO:0031093 (platelet alpha granule lumen)
GO:0043197 (dendritic spine)
GO:0043198 (dendritic shaft)
GO Molecular Function GO:0003677 (DNA binding)
GO:0004867 (serine-type endopeptidase inhibitor activity)
GO:0005515 (protein binding)
GO:0008201 (heparin binding)
GO:0033130 (acetylcholine receptor binding)
GO:0042802 (identical protein binding)
GO:0046872 (metal ion binding)
GO:0051425 (PTB domain binding)
GO Biological Process GO:0000085 (G2 phase of mitotic cell cycle)
GO:0002576 (platelet degranulation)
GO:0006378 (mRNA polyadenylation)
GO:0006417 (regulation of translation)
GO:0006468 (protein phosphorylation)
GO:0006878 (cellular copper ion homeostasis)
GO:0006897 (endocytosis)
GO:0007155 (cell adhesion)
GO:0007176 (regulation of epidermal growth factor receptor activity)
GO:0007219 (Notch signaling pathway)
GO:0007617 (mating behavior)
GO:0008088 (axon cargo transport)
GO:0008344 (adult locomotory behavior)
GO:0008542 (visual learning)
GO:0016199 (axon midline choice point recognition)
GO:0016322 (neuron remodeling)
GO:0016358 (dendrite development)
GO:0030168 (platelet activation)
GO:0030198 (extracellular matrix organization)
GO:0035235 (ionotropic glutamate receptor signaling pathway)
GO:0040014 (regulation of multicellular organism growth)
GO:0045087 (innate immune response)
GO:0045931 (positive regulation of mitotic cell cycle)
GO:0048669 (collateral sprouting in absence of injury)
GO:0050803 (regulation of synapse structure and activity)
GO:0051402 (neuron apoptosis)
Wikipedia Amyloid_precursor_protein

Target Cross References - Protein

canSAR P05067
CGD Alzheimer disease, familial; Cerebral amyloid angiopathy
Human Protein Atlas ENSG00000142192
IntAct P05067
MICAD NBK23203 (Aggregates of Amyloid-beta peptide)
NBK23213 (Aggregates of Beta-amyloid peptides)
NBK23443 (Aggregates of Beta-amyloid peptide)
NBK32300 (Amyloid-beta peptide)
NBK57129 (Amyloid-beta peptide)
NBK82968 (Beta-amyloid)
NBK82969 (Beta-amyloid (A-beta))
NBK84117 (Beta-amyloid plaques)
PharmGKB PA24910
Reactome REACT_14797 (Signaling by GPCR.)
REACT_604 (Hemostasis.)
REACT_6900 (Signaling in Immune system.)
UniProt B2R5V1 D3DSD1 D3DSD2 D3DSD3 P05067 P09000 P78438 Q13764 Q13778 Q13793 Q16011 Q16014 Q16019 Q16020 Q6GSC0 Q8WZ99 Q9BT38 Q9UC33 Q9UCA9 Q9UCB6 Q9UCC8 Q9UCD1 Q9UQ58

Target Cross References - Domain

InterPro IPR002223 (Prot_inh_Kunz-m.)
IPR008154 (Amyloid_glyco_extra.)
IPR008155 (Amyloid_glyco.)
IPR011178 (Amyloid_glyco_Cu-bd.)
IPR013803 (Amyloid_glyco_Abeta.)
IPR015849 (Amyloid_glyco_heparin-bd.)
IPR019543 (APP_amyloid_C.)
IPR019744 (Amyloid_glyco_extracell_CS.)
IPR019745 (Amyloid_glyco_intracell_CS.)
IPR020901 (Prtase_inh_Kunz-CS.)
Pfam PF00014 (Kunitz_BPTI)
PF02177 (A4_EXTRA)
PF03494 (Beta-APP)
PF10515 (APP_amyloid)

Target Cross References - Structure

PDBe 1AAP 1BRC 1CA0 1MWP 1RW6 1TAW 1X11 1ZJD 2FJZ 2FK1 2FK2 2FK3 2FKL 2FMA 2G47 2IPU 2R0W 2WK3 3DXC 3DXD 3DXE 3GCI 3IFL 3IFN More...
CREDO 1AAP 1BRC 1CA0 1MWP 1RW6 1TAW 1X11 1ZJD 2FJZ 2FK1 2FK2 2FK3 2FKL 2FMA 2G47 2IPU 2R0W 2WK3 3DXC 3DXD 3DXE 3GCI 3IFL 3IFN More...
spacer
spacer