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ChEMBL

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Target Report Card

Target Name and Classification

Target ID CHEMBL248
Target Type SINGLE PROTEIN
Preferred Name Leukocyte elastase
Synonyms Bone marrow serine protease | ELA2 | ELANE | Elastase-2 | HLE | Human leukocyte elastase | Medullasin | Neutrophil elastase | PMN elastase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > serine protease > serine protease pa clan > serine protease s1a subfamily

Target Components

Component Description Relationship Accession
Neutrophil elastase SINGLE PROTEIN P08246

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000197561
Ensembl ENSG00000197561
GO Cellular Component GO:0009986 (cell surface)
GO:0030141 (secretory granule)
GO:0005615 (extracellular space)
GO:0070062 (extracellular exosome)
GO:0005576 (extracellular region)
GO:0005737 (cytoplasm)
GO:0017053 (transcriptional repressor complex)
GO Molecular Function GO:0001106 (RNA polymerase II transcription corepressor activity)
GO:0002020 (protease binding)
GO:0004175 (endopeptidase activity)
GO:0008201 (heparin binding)
GO:0004252 (serine-type endopeptidase activity)
GO:0008233 (peptidase activity)
GO:0019955 (cytokine binding)
GO Biological Process GO:0045079 (negative regulation of chemokine biosynthetic process)
GO:0050922 (negative regulation of chemotaxis)
GO:0044130 (negative regulation of growth of symbiont in host)
GO:0001878 (response to yeast)
GO:0050900 (leukocyte migration)
GO:0006874 (cellular calcium ion homeostasis)
GO:0006909 (phagocytosis)
GO:0022617 (extracellular matrix disassembly)
GO:0030574 (collagen catabolic process)
GO:0045416 (positive regulation of interleukin-8 biosynthetic process)
GO:0070947 (neutrophil mediated killing of fungus)
GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0002438 (acute inflammatory response to antigenic stimulus)
GO:0030198 (extracellular matrix organization)
GO:0048661 (positive regulation of smooth muscle cell proliferation)
GO:0006508 (proteolysis)
GO:0009411 (response to UV)
GO:0045415 (negative regulation of interleukin-8 biosynthetic process)
GO:0050728 (negative regulation of inflammatory response)
GO:0042742 (defense response to bacterium)
GO:0030163 (protein catabolic process)
GO:0032496 (response to lipopolysaccharide)
GO:0043406 (positive regulation of MAP kinase activity)
GO:0050778 (positive regulation of immune response)
Wikipedia Neutrophil_elastase

Target Cross References - Protein

canSAR P08246
CGD Neutropenia, severe congenital 1, autosomal dominant; Neutropenia, cyclic
Human Protein Atlas ENSG00000197561
IntAct P08246
Guide to Pharmacology 2358 (elastase, neutrophil expressed)
PharmGKB PA27735
UniProt Q6B0D9 P08246 P09649 Q6LDP5

Target Cross References - Domain

InterPro IPR001314 (Peptidase_S1A.)
IPR001254 (Trypsin_dom.)
IPR009003 (Peptidase_S1_PA.)
IPR018114 (Peptidase_S1_AS.)
Pfam PF00089 (Trypsin)

Target Cross References - Structure

PDBe 1B0F 1PPF 2RG3 2Z7F 4NZL 4WVP 5A0A 5A0C 3Q76 5A0B 1H1B 3Q77 5ABW 5A09 1HNE 1PPG
CREDO 1B0F 1PPF 2RG3 2Z7F 4NZL 4WVP 5A0A 5A0C 3Q76 5A0B 1H1B 3Q77 5ABW 5A09 1HNE 1PPG
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