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Target Report Card

Target Name and Classification

Target ID CHEMBL248
Target Type SINGLE PROTEIN
Preferred Name Leukocyte elastase
Synonyms Bone marrow serine protease | ELA2 | ELANE | Elastase-2 | HLE | Human leukocyte elastase | Medullasin | Neutrophil elastase | PMN elastase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > serine protease > serine protease pa clan > serine protease s1a subfamily

Target Components

Component Description Relationship Accession
Neutrophil elastase SINGLE PROTEIN P08246

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000197561
Ensembl ENSG00000197561
GO Cellular Component GO:0005576 (extracellular region)
GO:0009986 (cell surface)
GO:0030141 (stored secretory granule)
GO Molecular Function GO:0008201 (heparin binding)
GO:0019955 (cytokine binding)
GO:0051635 (bacterial cell surface binding)
GO Biological Process GO:0006508 (proteolysis)
GO:0006874 (cellular calcium ion homeostasis)
GO:0009411 (response to UV)
GO:0030163 (protein catabolic process)
GO:0043406 (positive regulation of MAP kinase activity)
GO:0045079 (negative regulation of chemokine biosynthetic process)
GO:0045415 (negative regulation of interleukin-8 biosynthetic process)
GO:0045416 (positive regulation of interleukin-8 biosynthetic process)
GO:0048661 (positive regulation of smooth muscle cell proliferation)
GO:0050728 (negative regulation of inflammatory response)
GO:0050922 (negative regulation of chemotaxis)
Wikipedia Neutrophil_elastase

Target Cross References - Protein

canSAR P08246
CGD Neutropenia, severe congenital 1, autosomal dominant; Neutropenia, cyclic
Human Protein Atlas ENSG00000197561
IntAct P08246
Guide to Pharmacology 2358 (elastase, neutrophil expressed)
PharmGKB PA27735
UniProt P08246 P09649 Q6B0D9 Q6LDP5

Target Cross References - Domain

InterPro IPR001254 (Peptidase_S1_S6.)
IPR001314 (Peptidase_S1A.)
IPR009003 (Pept_cys/ser_Trypsin-like.)
IPR018114 (Peptidase_S1/S6_AS.)
Pfam PF00089 (Trypsin)

Target Cross References - Structure

PDBe 1B0F 1H1B 1HNE 1PPF 1PPG 2RG3 2Z7F
CREDO 1B0F 1H1B 1HNE 1PPF 1PPG 2RG3 2Z7F
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