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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2476
Target Type SINGLE PROTEIN
Preferred Name Voltage-gated potassium channel subunit Kv7.2
Synonyms KCNQ2 | KQT-like 2 | Neuroblastoma-specific potassium channel subunit alpha KvLQT2 | Potassium voltage-gated channel subfamily KQT member 2 | Voltage-gated potassium channel subunit Kv7.2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > voltage-gated ion channel > potassium channels > voltage-gated potassium channel

Target Components

Component Description Relationship Accession
Potassium voltage-gated channel subfamily KQT member 2 SINGLE PROTEIN O43526

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2221348 Voltage-gated potassium channel, KQT; KCNQ2(Kv7.2)/KCNQ3(Kv7.3) PROTEIN COMPLEX
CHEMBL2362996 Voltage-gated potassium channel PROTEIN FAMILY
CHEMBL2363063 KCNQ (Kv7) potassium channel PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL266510 FLINDOKALNER Voltage-gated potassium channel subunit Kv7.2 activator 3 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000075043
Ensembl ENSG00000075043
GO Cellular Component GO:0005886 (plasma membrane)
GO:0008076 (voltage-gated potassium channel complex)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0033268 (node of Ranvier)
GO:0043194 (axon initial segment)
GO Molecular Function GO:0005216 (ion channel activity)
GO:0005244 (voltage-gated ion channel activity)
GO:0005249 (voltage-gated potassium channel activity)
GO:0005251 (delayed rectifier potassium channel activity)
GO:0005267 (potassium channel activity)
GO:0030506 (ankyrin binding)
GO Biological Process GO:0006810 (transport)
GO:0006811 (ion transport)
GO:0006813 (potassium ion transport)
GO:0007268 (chemical synaptic transmission)
GO:0007399 (nervous system development)
GO:0034765 (regulation of ion transmembrane transport)
GO:0055085 (transmembrane transport)
GO:0071805 (potassium ion transmembrane transport)
Wikipedia KvLQT2

Target Cross References - Protein

canSAR O43526
CGD Epileptic encephalopathy, early infantile, 7; Benign familial neonatal seizures, 1; Myokymia
Human Protein Atlas ENSG00000075043
IntAct O43526
Guide to Pharmacology 561
Open Targets ENSG00000075043
PharmGKB PA30074
Pharos O43526 (Tclin)
Reactome R-HSA-1296072 (Voltage gated Potassium channels.)
R-HSA-445095 (Interaction between L1 and Ankyrins.)
UniProt O43526 O43796 O75580 O95845 Q4VXP4 Q4VXR6 Q5VYT8 Q96J59 Q99454

Target Cross References - Domain

InterPro IPR003937 (K_chnl_volt-dep_KCNQ.)
IPR003947 (K_chnl_volt-dep_KCNQ2.)
IPR005821 (Ion_trans_dom.)
IPR013821 (K_chnl_volt-dep_KCNQ_C.)
IPR020969 (Ankyrin-G_BS.)
IPR028325 (VG_K_chnl.)
Pfam PF00520 (Ion_trans)
PF03520 (KCNQ_channel)
PF11956 (KCNQC3-Ank-G_bd)

Target Cross References - Structure

PDBe 5J03
CREDO 5J03
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