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Target Report Card

Target Name and Classification

Target ID CHEMBL2473
Preferred Name Presenilin 1
Synonyms AD3 | PS-1 | PS1 | PS1-CTF12 | PSEN1 | PSNL1 | Presenilin-1 CTF subunit | Presenilin-1 CTF12 | Presenilin-1 NTF subunit | Presenilin-1 | Protein S182
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > other ion channel > miscellaneous ion channel > presenilin er ca2+ leak channel family

Target Components

Component Description Relationship Accession
Presenilin-1 SINGLE PROTEIN P49768

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2094135 Gamma-secretase PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000080815
Ensembl ENSG00000080815
GO Cellular Component GO:0000139 (Golgi membrane)
GO:0000776 (kinetochore)
GO:0005622 (intracellular)
GO:0005634 (nucleus)
GO:0005640 (nuclear outer membrane)
GO:0005739 (mitochondrion)
GO:0005743 (mitochondrial inner membrane)
GO:0005765 (lysosomal membrane)
GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005790 (smooth endoplasmic reticulum)
GO:0005791 (rough endoplasmic reticulum)
GO:0005794 (Golgi apparatus)
GO:0005813 (centrosome)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016235 (aggresome)
GO:0030054 (cell junction)
GO:0030424 (axon)
GO:0030425 (dendrite)
GO:0030426 (growth cone)
GO:0031410 (cytoplasmic vesicle)
GO:0031594 (neuromuscular junction)
GO:0031965 (nuclear membrane)
GO:0035253 (ciliary rootlet)
GO:0043005 (neuron projection)
GO:0043025 (neuronal cell body)
GO:0043198 (dendritic shaft)
GO:0043227 (membrane-bounded organelle)
GO:0043234 (protein complex)
GO:0045121 (membrane raft)
GO:0070765 (gamma-secretase complex)
GO:0098793 (presynapse)
GO Molecular Function GO:0004175 (endopeptidase activity)
GO:0004190 (aspartic-type endopeptidase activity)
GO:0005262 (calcium channel activity)
GO:0005515 (protein binding)
GO:0008013 (beta-catenin binding)
GO:0008233 (peptidase activity)
GO:0016787 (hydrolase activity)
GO:0030165 (PDZ domain binding)
GO:0045296 (cadherin binding)
GO Biological Process GO:0000045 (autophagosome assembly)
GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0000186 (activation of MAPKK activity)
GO:0001568 (blood vessel development)
GO:0001708 (cell fate specification)
GO:0001756 (somitogenesis)
GO:0001764 (neuron migration)
GO:0001921 (positive regulation of receptor recycling)
GO:0001933 (negative regulation of protein phosphorylation)
GO:0001934 (positive regulation of protein phosphorylation)
GO:0001947 (heart looping)
GO:0002244 (hematopoietic progenitor cell differentiation)
GO:0002286 (T cell activation involved in immune response)
GO:0002573 (myeloid leukocyte differentiation)
GO:0003407 (neural retina development)
GO:0006469 (negative regulation of protein kinase activity)
GO:0006486 (protein glycosylation)
GO:0006508 (proteolysis)
GO:0006509 (membrane protein ectodomain proteolysis)
GO:0006839 (mitochondrial transport)
GO:0006874 (cellular calcium ion homeostasis)
GO:0006914 (autophagy)
GO:0006915 (apoptotic process)
GO:0006974 (cellular response to DNA damage stimulus)
GO:0006979 (response to oxidative stress)
GO:0007155 (cell adhesion)
GO:0007175 (negative regulation of epidermal growth factor-activated receptor activity)
GO:0007176 (regulation of epidermal growth factor-activated receptor activity)
GO:0007219 (Notch signaling pathway)
GO:0007220 (Notch receptor processing)
GO:0007420 (brain development)
GO:0007507 (heart development)
GO:0007611 (learning or memory)
GO:0007613 (memory)
GO:0009791 (post-embryonic development)
GO:0015031 (protein transport)
GO:0015813 (L-glutamate transport)
GO:0015871 (choline transport)
GO:0016080 (synaptic vesicle targeting)
GO:0016337 (single organismal cell-cell adhesion)
GO:0016485 (protein processing)
GO:0021795 (cerebral cortex cell migration)
GO:0021870 (Cajal-Retzius cell differentiation)
GO:0021904 (dorsal/ventral neural tube patterning)
GO:0021987 (cerebral cortex development)
GO:0022008 (neurogenesis)
GO:0030182 (neuron differentiation)
GO:0030326 (embryonic limb morphogenesis)
GO:0030900 (forebrain development)
GO:0032436 (positive regulation of proteasomal ubiquitin-dependent protein catabolic process)
GO:0032469 (endoplasmic reticulum calcium ion homeostasis)
GO:0034205 (beta-amyloid formation)
GO:0035282 (segmentation)
GO:0035556 (intracellular signal transduction)
GO:0040011 (locomotion)
GO:0042325 (regulation of phosphorylation)
GO:0042987 (amyloid precursor protein catabolic process)
GO:0043011 (myeloid dendritic cell differentiation)
GO:0043065 (positive regulation of apoptotic process)
GO:0043066 (negative regulation of apoptotic process)
GO:0043085 (positive regulation of catalytic activity)
GO:0043393 (regulation of protein binding)
GO:0043406 (positive regulation of MAP kinase activity)
GO:0043524 (negative regulation of neuron apoptotic process)
GO:0043589 (skin morphogenesis)
GO:0044267 (cellular protein metabolic process)
GO:0045860 (positive regulation of protein kinase activity)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0048167 (regulation of synaptic plasticity)
GO:0048538 (thymus development)
GO:0048666 (neuron development)
GO:0048705 (skeletal system morphogenesis)
GO:0048854 (brain morphogenesis)
GO:0050435 (beta-amyloid metabolic process)
GO:0050673 (epithelial cell proliferation)
GO:0050771 (negative regulation of axonogenesis)
GO:0050820 (positive regulation of coagulation)
GO:0050852 (T cell receptor signaling pathway)
GO:0051402 (neuron apoptotic process)
GO:0051444 (negative regulation of ubiquitin-protein transferase activity)
GO:0051563 (smooth endoplasmic reticulum calcium ion homeostasis)
GO:0051604 (protein maturation)
GO:0051966 (regulation of synaptic transmission, glutamatergic)
GO:0060070 (canonical Wnt signaling pathway)
GO:0060075 (regulation of resting membrane potential)
GO:0060999 (positive regulation of dendritic spine development)
GO:0070588 (calcium ion transmembrane transport)
GO:2000059 (negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process)
GO:2001234 (negative regulation of apoptotic signaling pathway)
Wikipedia PSEN1

Target Cross References - Protein

canSAR P49768
CGD Cardiomyopathy, dilated 1U
Human Protein Atlas ENSG00000080815
IntAct P49768
Guide to Pharmacology 2402
Open Targets ENSG00000080815
PharmGKB PA33855
Reactome R-HSA-1474228 (Degradation of the extracellular matrix.)
R-HSA-6798695 (Neutrophil degranulation.)
UniProt B2R6D3 O95465 P49768 Q14762 Q15719 Q15720 Q96P33 Q9UIF0

Target Cross References - Domain

InterPro IPR001108 (Peptidase_A22A.)
IPR002031 (Pept_A22A_PS1.)
IPR006639 (Preselin/SPP.)
Pfam PF01080 (Presenilin)