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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2473
Preferred Name Presenilin 1
Synonyms AD3 | PS-1 | PS1 | PS1-CTF12 | PSEN1 | PSNL1 | Presenilin-1 | Presenilin-1 CTF subunit | Presenilin-1 CTF12 | Presenilin-1 NTF subunit | Protein S182
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > other ion channel > miscellaneous ion channel > presenilin er ca2+ leak channel family

Target Components

Component Description Relationship Accession
Presenilin-1 SINGLE PROTEIN P49768

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2094135 Gamma-secretase PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Expression Atlas ENSG00000080815
Ensembl ENSG00000080815
GO Cellular Component GO:0000139 (Golgi membrane)
GO:0000776 (kinetochore)
GO:0005640 (nuclear outer membrane)
GO:0005743 (mitochondrial inner membrane)
GO:0005765 (lysosomal membrane)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005790 (smooth endoplasmic reticulum)
GO:0005791 (rough endoplasmic reticulum)
GO:0005813 (centrosome)
GO:0005887 (integral to plasma membrane)
GO:0005938 (cell cortex)
GO:0009986 (cell surface)
GO:0016324 (apical plasma membrane)
GO:0030018 (Z disc)
GO:0030424 (axon)
GO:0030426 (growth cone)
GO:0031594 (neuromuscular junction)
GO:0035253 (ciliary rootlet)
GO:0043025 (neuronal cell body)
GO:0043198 (dendritic shaft)
GO:0045121 (membrane raft)
GO:0048471 (perinuclear region of cytoplasm)
GO:0070765 (gamma-secretase complex)
GO Molecular Function GO:0004190 (aspartic-type endopeptidase activity)
GO:0005262 (calcium channel activity)
GO:0008013 (beta-catenin binding)
GO:0030165 (PDZ domain binding)
GO:0045296 (cadherin binding)
GO Biological Process GO:0006509 (membrane protein ectodomain proteolysis)
GO:0006916 (anti-apoptosis)
GO:0007219 (Notch signaling pathway)
GO:0007220 (Notch receptor processing)
GO:0008624 (induction of apoptosis by extracellular signals)
GO:0016337 (cell-cell adhesion)
GO:0031293 (membrane protein intracellular domain proteolysis)
GO:0042987 (amyloid precursor protein catabolic process)
GO:0048011 (nerve growth factor receptor signaling pathway)
GO:0050435 (beta-amyloid metabolic process)
GO:0051563 (smooth endoplasmic reticulum calcium ion homeostasis)
Wikipedia PSEN1

Target Cross References - Protein

canSAR P49768
CGD Cardiomyopathy, dilated 1U
Human Protein Atlas ENSG00000080815
IntAct P49768
Guide to Pharmacology 2402 (presenilin 1)
PharmGKB PA33855
Reactome REACT_11061 (Signalling by NGF.)
REACT_299 (Signaling by Notch.)
UniProt B2R6D3 O95465 P49768 Q14762 Q15719 Q15720 Q96P33 Q9UIF0

Target Cross References - Domain

InterPro IPR001108 (Peptidase_A22A.)
IPR002031 (Pept_A22A_PS1.)
IPR006639 (Peptidase_A22.)
Pfam PF01080 (Presenilin)