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Target Report Card

Target Name and Classification

Target ID CHEMBL2473
Preferred Name Presenilin 1
Synonyms AD3 | PS-1 | PS1 | PS1-CTF12 | PSEN1 | PSNL1 | Presenilin-1 | Presenilin-1 CTF subunit | Presenilin-1 CTF12 | Presenilin-1 NTF subunit | Protein S182
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > other ion channel > miscellaneous ion channel > presenilin er ca2+ leak channel family

Target Components

Component Description Relationship Accession
Presenilin-1 SINGLE PROTEIN P49768

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2094135 Gamma-secretase PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000080815
Ensembl ENSG00000080815
GO Cellular Component GO:0005640 (nuclear outer membrane)
GO:0005790 (smooth endoplasmic reticulum)
GO:0005938 (cell cortex)
GO:0030426 (growth cone)
GO:0043025 (neuronal cell body)
GO:0000139 (Golgi membrane)
GO:0005739 (mitochondrion)
GO:0005887 (integral component of plasma membrane)
GO:0009986 (cell surface)
GO:0031965 (nuclear membrane)
GO:0043198 (dendritic shaft)
GO:0005765 (lysosomal membrane)
GO:0005794 (Golgi apparatus)
GO:0005813 (centrosome)
GO:0016324 (apical plasma membrane)
GO:0030018 (Z disc)
GO:0030424 (axon)
GO:0016020 (membrane)
GO:0005634 (nucleus)
GO:0031410 (cytoplasmic vesicle)
GO:0048471 (perinuclear region of cytoplasm)
GO:0070765 (gamma-secretase complex)
GO:0005789 (endoplasmic reticulum membrane)
GO:0016235 (aggresome)
GO:0000776 (kinetochore)
GO:0005743 (mitochondrial inner membrane)
GO:0016021 (integral component of membrane)
GO:0031594 (neuromuscular junction)
GO:0035253 (ciliary rootlet)
GO:0005783 (endoplasmic reticulum)
GO:0005791 (rough endoplasmic reticulum)
GO:0005886 (plasma membrane)
GO:0030054 (cell junction)
GO:0045121 (membrane raft)
GO Molecular Function GO:0045296 (cadherin binding)
GO:0004175 (endopeptidase activity)
GO:0030165 (PDZ domain binding)
GO:0005262 (calcium channel activity)
GO:0004190 (aspartic-type endopeptidase activity)
GO:0008013 (beta-catenin binding)
GO Biological Process GO:0000045 (autophagosome assembly)
GO:0007175 (negative regulation of epidermal growth factor-activated receptor activity)
GO:0007613 (memory)
GO:0032436 (positive regulation of proteasomal ubiquitin-dependent protein catabolic process)
GO:0051563 (smooth endoplasmic reticulum calcium ion homeostasis)
GO:0060999 (positive regulation of dendritic spine development)
GO:0006974 (cellular response to DNA damage stimulus)
GO:0015813 (L-glutamate transport)
GO:0042325 (regulation of phosphorylation)
GO:0043066 (negative regulation of apoptotic process)
GO:0043589 (skin morphogenesis)
GO:0001568 (blood vessel development)
GO:0021870 (Cajal-Retzius cell differentiation)
GO:0048538 (thymus development)
GO:0070588 (calcium ion transmembrane transport)
GO:0001764 (neuron migration)
GO:0007219 (Notch signaling pathway)
GO:0007220 (Notch receptor processing)
GO:0016337 (single organismal cell-cell adhesion)
GO:0021904 (dorsal/ventral neural tube patterning)
GO:0022617 (extracellular matrix disassembly)
GO:0035556 (intracellular signal transduction)
GO:0050435 (beta-amyloid metabolic process)
GO:0050673 (epithelial cell proliferation)
GO:0051444 (negative regulation of ubiquitin-protein transferase activity)
GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0001921 (positive regulation of receptor recycling)
GO:0003407 (neural retina development)
GO:0009791 (post-embryonic development)
GO:0015871 (choline transport)
GO:0030198 (extracellular matrix organization)
GO:0043393 (regulation of protein binding)
GO:0048167 (regulation of synaptic plasticity)
GO:0048705 (skeletal system morphogenesis)
GO:0050820 (positive regulation of coagulation)
GO:0050852 (T cell receptor signaling pathway)
GO:0060075 (regulation of resting membrane potential)
GO:0001708 (cell fate specification)
GO:0002286 (T cell activation involved in immune response)
GO:0016485 (protein processing)
GO:0030326 (embryonic limb morphogenesis)
GO:0032469 (endoplasmic reticulum calcium ion homeostasis)
GO:0042987 (amyloid precursor protein catabolic process)
GO:0043065 (positive regulation of apoptotic process)
GO:0051966 (regulation of synaptic transmission, glutamatergic)
GO:2001234 (negative regulation of apoptotic signaling pathway)
GO:0000186 (activation of MAPKK activity)
GO:0001947 (heart looping)
GO:0006486 (protein glycosylation)
GO:0006839 (mitochondrial transport)
GO:0015031 (protein transport)
GO:0016080 (synaptic vesicle targeting)
GO:0043085 (positive regulation of catalytic activity)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0048666 (neuron development)
GO:0051402 (neuron apoptotic process)
GO:2000059 (negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process)
GO:0001756 (somitogenesis)
GO:0002244 (hematopoietic progenitor cell differentiation)
GO:0006509 (membrane protein ectodomain proteolysis)
GO:0006979 (response to oxidative stress)
GO:0021795 (cerebral cortex cell migration)
GO:0034205 (beta-amyloid formation)
GO:0043011 (myeloid dendritic cell differentiation)
GO:0043406 (positive regulation of MAP kinase activity)
GO:0043524 (negative regulation of neuron apoptotic process)
GO:0048854 (brain morphogenesis)
GO:0050771 (negative regulation of axonogenesis)
GO:0060070 (canonical Wnt signaling pathway)
Wikipedia PSEN1

Target Cross References - Protein

canSAR P49768
CGD Cardiomyopathy, dilated 1U
Human Protein Atlas ENSG00000080815
IntAct P49768
Guide to Pharmacology 2402 (presenilin 1)
PharmGKB PA33855
UniProt O95465 Q96P33 Q15720 Q9UIF0 Q14762 Q15719 B2R6D3 P49768

Target Cross References - Domain

InterPro IPR001108 (Peptidase_A22A.)
IPR006639 (Preselin/SPP.)
IPR002031 (Pept_A22A_PS1.)
Pfam PF01080 (Presenilin)