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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2472
Preferred Name GABA receptor alpha-4 subunit
Synonyms GABA(A) receptor subunit alpha-4 | GABRA4 | Gamma-aminobutyric acid receptor subunit alpha-4
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > ligand-gated ion channel > gaba-a receptor

Target Components

Component Description Relationship Accession
Gamma-aminobutyric acid receptor subunit alpha-4 SINGLE PROTEIN P48169

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111366 GABA A receptor alpha-4/beta-3/gamma-2 PROTEIN COMPLEX
CHEMBL2093872 GABA-A receptor; anion channel PROTEIN COMPLEX GROUP
CHEMBL2109244 GABA-A receptor; agonist GABA site PROTEIN COMPLEX GROUP
CHEMBL2109243 GABA-A receptor; benzodiazepine site PROTEIN COMPLEX GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000109158
Ensembl ENSG00000109158
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030054 (cell junction)
GO:0034707 (chloride channel complex)
GO:0045202 (synapse)
GO:0045211 (postsynaptic membrane)
GO:1902711 (GABA-A receptor complex)
GO Molecular Function GO:0004890 (GABA-A receptor activity)
GO:0005216 (ion channel activity)
GO:0005230 (extracellular ligand-gated ion channel activity)
GO:0005254 (chloride channel activity)
GO:0008503 (benzodiazepine receptor activity)
GO Biological Process GO:0006810 (transport)
GO:0006811 (ion transport)
GO:0006821 (chloride transport)
GO:0007214 (gamma-aminobutyric acid signaling pathway)
GO:0007268 (chemical synaptic transmission)
GO:0007417 (central nervous system development)
GO:0034220 (ion transmembrane transport)
GO:0099565 (chemical synaptic transmission, postsynaptic)
GO:1902476 (chloride transmembrane transport)
GO:2001023 (regulation of response to drug)
Wikipedia GABRA4

Target Cross References - Protein

canSAR P48169
Human Protein Atlas ENSG00000109158
IntAct P48169
Open Targets ENSG00000109158
PharmGKB PA28492
Pharos P48169 (Tclin)
Reactome R-HSA-112314 (Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell.)
R-HSA-975298 (Ligand-gated ion channel transport.)
R-HSA-977441 (GABA A receptor activation.)
UniProt P48169 Q8IYR7

Target Cross References - Domain

InterPro IPR001390 (GABAAa_rcpt.)
IPR005434 (GABBAa4_rcpt.)
IPR006028 (GABAA/Glycine_rcpt.)
IPR006029 (Neurotrans-gated_channel_TM.)
IPR006201 (Neur_channel.)
IPR006202 (Neur_chan_lig-bd.)
IPR018000 (Neurotransmitter_ion_chnl_CS.)
Pfam PF02931 (Neur_chan_LBD)
PF02932 (Neur_chan_memb)