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Target Report Card

Target Name and Classification

Target ID CHEMBL2468
Target Type SINGLE PROTEIN
Preferred Name Death-associated protein kinase 3
Synonyms DAP kinase 3 | DAP-like kinase | DAPK3 | Death-associated protein kinase 3 | Dlk | MYPT1 kinase | ZIP-kinase | ZIPK | Zipper-interacting protein kinase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > camk protein kinase group > camk protein kinase dapk family

Target Components

Component Description Relationship Accession
Death-associated protein kinase 3 SINGLE PROTEIN O43293

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000167657
Ensembl ENSG00000167657
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005884 (actin filament)
GO:0016605 (PML body)
GO:0045121 (membrane raft)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0008022 (protein C-terminus binding)
GO:0008140 (cAMP response element binding protein binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0017048 (Rho GTPase binding)
GO:0042802 (identical protein binding)
GO:0042803 (protein homodimerization activity)
GO:0043522 (leucine zipper domain binding)
GO Biological Process GO:0000910 (cytokinesis)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006417 (regulation of translation)
GO:0006468 (protein phosphorylation)
GO:0006915 (apoptotic process)
GO:0006940 (regulation of smooth muscle contraction)
GO:0007088 (regulation of mitotic nuclear division)
GO:0007346 (regulation of mitotic cell cycle)
GO:0008360 (regulation of cell shape)
GO:0010506 (regulation of autophagy)
GO:0016310 (phosphorylation)
GO:0016568 (chromatin modification)
GO:0017148 (negative regulation of translation)
GO:0030182 (neuron differentiation)
GO:0030335 (positive regulation of cell migration)
GO:0035556 (intracellular signal transduction)
GO:0042981 (regulation of apoptotic process)
GO:0043065 (positive regulation of apoptotic process)
GO:0043519 (regulation of myosin II filament organization)
GO:0046777 (protein autophosphorylation)
GO:0051893 (regulation of focal adhesion assembly)
GO:0071346 (cellular response to interferon-gamma)
GO:0090263 (positive regulation of canonical Wnt signaling pathway)
GO:0097190 (apoptotic signaling pathway)
GO:2000145 (regulation of cell motility)
GO:2000249 (regulation of actin cytoskeleton reorganization)
GO:2001241 (positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)
Wikipedia DAPK3

Target Cross References - Protein

canSAR O43293
Human Protein Atlas ENSG00000167657
IntAct O43293
Guide to Pharmacology 2004
Open Targets ENSG00000167657
PharmGKB PA27144
Pharos O43293 (Tchem)
Reactome R-HSA-418889 (Ligand-independent caspase activation via DCC.)
UniProt A0AVN4 B3KQE2 O43293 Q05JY4

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020636 (Ca/CaM-dep_Ca-dep_prot_Kinase.)
Pfam PF00069 (Pkinase)

Target Cross References - Structure

PDBe 1YRP 2J90 3BHY 3BQR 5A6N 5A6O
CREDO 1YRP 2J90 3BHY 3BQR 5A6N 5A6O
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