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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2465
Target Type SINGLE PROTEIN
Preferred Name Dihydropyrimidinase
Synonyms DHP | DHPase | DPYS | Dihydropyrimidinase | Dihydropyrimidine amidohydrolase | Hydantoinase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Dihydropyrimidinase SINGLE PROTEIN Q14117

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000147647
Ensembl ENSG00000147647
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0002058 (uracil binding)
GO:0002059 (thymine binding)
GO:0004157 (dihydropyrimidinase activity)
GO:0008270 (zinc ion binding)
GO:0016597 (amino acid binding)
GO:0016787 (hydrolase activity)
GO:0016810 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds)
GO:0046872 (metal ion binding)
GO:0051219 (phosphoprotein binding)
GO Biological Process GO:0006208 (pyrimidine nucleobase catabolic process)
GO:0006210 (thymine catabolic process)
GO:0006212 (uracil catabolic process)
GO:0019482 (beta-alanine metabolic process)
GO:0019860 (uracil metabolic process)
GO:0046135 (pyrimidine nucleoside catabolic process)
GO:0051260 (protein homooligomerization)
GO:0051289 (protein homotetramerization)
Wikipedia DPYS

Target Cross References - Protein

canSAR Q14117
CGD Dihydropyriminidase deficiency
Human Protein Atlas ENSG00000147647
IntAct Q14117
Open Targets ENSG00000147647
PharmGKB PA146
Reactome R-HSA-73621 (Pyrimidine catabolism.)
UniProt Q14117

Target Cross References - Domain

InterPro IPR006680 (Amidohydro-rel.)
IPR011059 (Metal-dep_hydrolase_composite.)
IPR011778 (Hydantoinase/dihydroPyrase.)
IPR030633 (Dihydropyrimidinase.)
IPR032466 (Metal_Hydrolase.)
Pfam PF01979 (Amidohydro_1)

Target Cross References - Structure

PDBe 2VR2
CREDO 2VR2
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