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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2447
Target Type SINGLE PROTEIN
Preferred Name Deoxycytidine kinase
Synonyms DCK | Deoxycytidine kinase | dCK
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Deoxycytidine kinase SINGLE PROTEIN P27707

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000156136
Ensembl ENSG00000156136
GO Cellular Component GO:0005634 (nucleus)
GO:0005829 (cytosol)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004137 (deoxycytidine kinase activity)
GO:0005524 (ATP binding)
GO:0008144 (drug binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0019206 (nucleoside kinase activity)
GO:0042803 (protein homodimerization activity)
GO Biological Process GO:0006139 (nucleobase-containing compound metabolic process)
GO:0006220 (pyrimidine nucleotide metabolic process)
GO:0009157 (deoxyribonucleoside monophosphate biosynthetic process)
GO:0009165 (nucleotide biosynthetic process)
GO:0016310 (phosphorylation)
GO:0043097 (pyrimidine nucleoside salvage)
GO:0043101 (purine-containing compound salvage)
Wikipedia Deoxycytidine_kinase

Target Cross References - Protein

canSAR P27707
Human Protein Atlas ENSG00000156136
IntAct P27707
Open Targets ENSG00000156136
PharmGKB PA137
Pharos P27707 (Tchem)
Reactome R-HSA-73614 (Pyrimidine salvage reactions.)
R-HSA-74217 (Purine salvage.)
UniProt B2R8V6 P27707 Q5TZY7 Q6FI11

Target Cross References - Domain

InterPro IPR002624 (DCK/DGK.)
IPR027417 (P-loop_NTPase.)
IPR031314 (DNK_dom.)
Pfam PF01712 (dNK)

Target Cross References - Structure

PDBe 1P5Z 1P60 1P61 1P62 2A2Z 2A30 2A7Q 2NO0 2NO1 2NO6 2NO7 2NO9 2NOA 2QRN 2QRO 2ZI3 2ZI4 2ZI5 2ZI6 2ZI7 2ZI9 2ZIA 3HP1 3IPX More...
CREDO 1P5Z 1P60 1P61 1P62 2A2Z 2A30 2A7Q 2NO0 2NO1 2NO6 2NO7 2NO9 2NOA 2QRN 2QRO 2ZI3 2ZI4 2ZI5 2ZI6 2ZI7 2ZI9 2ZIA 3HP1 3IPX More...
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