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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL244
Target Type SINGLE PROTEIN
Preferred Name Coagulation factor X
Synonyms Activated factor Xa heavy chain | Coagulation factor X | F10 | Factor X heavy chain | Factor X light chain | Stuart factor | Stuart-Prower factor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > serine protease > serine protease pa clan > serine protease s1a subfamily

Target Components

Component Description Relationship Accession
Coagulation factor X SINGLE PROTEIN P00742

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111412 Coagulation factor VII and X SELECTIVITY GROUP
CHEMBL2111424 Coagulation factor IX and X SELECTIVITY GROUP
CHEMBL2111449 Coagulation factor X/antithrombin III PROTEIN COMPLEX
CHEMBL2111419 Coagulation factor X and plasma kallikrein SELECTIVITY GROUP
CHEMBL2111401 Thrombin and coagulation factor X SELECTIVITY GROUP

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL198362 RIVAROXABAN Coagulation factor X inhibitor 4 DailyMed
CHEMBL231779 APIXABAN Coagulation factor X inhibitor 4 DailyMed
CHEMBL2105682 EDOXABAN TOSYLATE Coagulation factor X inhibitor 4 FDA

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000126218
Ensembl ENSG00000126218
GO Cellular Component GO:0005576 (extracellular region)
GO:0005788 (endoplasmic reticulum lumen)
GO:0005796 (Golgi lumen)
GO:0005886 (plasma membrane)
GO:0031233 (intrinsic component of external side of plasma membrane)
GO Molecular Function GO:0004252 (serine-type endopeptidase activity)
GO:0005509 (calcium ion binding)
GO:0005515 (protein binding)
GO:0005543 (phospholipid binding)
GO:0008233 (peptidase activity)
GO:0008236 (serine-type peptidase activity)
GO:0016787 (hydrolase activity)
GO Biological Process GO:0006465 (signal peptide processing)
GO:0006508 (proteolysis)
GO:0006888 (ER to Golgi vesicle-mediated transport)
GO:0007596 (blood coagulation)
GO:0007597 (blood coagulation, intrinsic pathway)
GO:0007598 (blood coagulation, extrinsic pathway)
GO:0007599 (hemostasis)
GO:0017187 (peptidyl-glutamic acid carboxylation)
GO:0030335 (positive regulation of cell migration)
GO:0051897 (positive regulation of protein kinase B signaling)
Wikipedia Factor_X

Target Cross References - Protein

canSAR P00742
CGD Factor X deficiency
Human Protein Atlas ENSG00000126218
IntAct P00742
Guide to Pharmacology 2359
Open Targets ENSG00000126218
PharmGKB PA27940
Reactome R-HSA-140834 (Extrinsic Pathway of Fibrin Clot Formation.)
R-HSA-140837 (Intrinsic Pathway of Fibrin Clot Formation.)
R-HSA-140875 (Common Pathway of Fibrin Clot Formation.)
R-HSA-159740 (Gamma-carboxylation of protein precursors.)
R-HSA-159763 (Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus.)
R-HSA-159782 (Removal of aminoterminal propeptides from gamma-carboxylated proteins.)
UniProt P00742 Q14340

Target Cross References - Domain

InterPro IPR000152 (EGF-type_Asp/Asn_hydroxyl_site.)
IPR000294 (GLA_domain.)
IPR000742 (EGF-like_dom.)
IPR001254 (Trypsin_dom.)
IPR001314 (Peptidase_S1A.)
IPR001881 (EGF-like_Ca-bd_dom.)
IPR009003 (Peptidase_S1_PA.)
IPR012224 (Pept_S1A_FX.)
IPR013032 (EGF-like_CS.)
IPR017857 (Coagulation_fac_subgr_Gla_dom.)
IPR018097 (EGF_Ca-bd_CS.)
IPR018114 (TRYPSIN_HIS.)
IPR033116 (TRYPSIN_SER.)
Pfam PF00008 (EGF)
PF00089 (Trypsin)
PF00594 (Gla)

Target Cross References - Structure

PDBe 1C5M 1EZQ 1F0R 1F0S 1FAX 1FJS 1FXY 1G2L 1G2M 1HCG 1IOE 1IQE 1IQF 1IQG 1IQH 1IQI 1IQJ 1IQK 1IQL 1IQM 1IQN 1KSN 1LPG 1LPK More...
CREDO 1C5M 1EZQ 1F0R 1F0S 1FAX 1FJS 1FXY 1G2L 1G2M 1HCG 1IOE 1IQE 1IQF 1IQG 1IQH 1IQI 1IQJ 1IQK 1IQL 1IQM 1IQN 1KSN 1LPG 1LPK More...
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