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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2439
Target Type SINGLE PROTEIN
Preferred Name Myeloperoxidase
Synonyms 84 kDa myeloperoxidase | 89 kDa myeloperoxidase | MPO | MPO | Myeloperoxidase heavy chain | Myeloperoxidase light chain | Myeloperoxidase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Myeloperoxidase SINGLE PROTEIN P05164

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000005381
Ensembl ENSG00000005381
GO Cellular Component GO:0005615 (extracellular space)
GO:0005634 (nucleus)
GO:0005739 (mitochondrion)
GO:0005764 (lysosome)
GO:0030141 (secretory granule)
GO:0042582 (azurophil granule)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0003682 (chromatin binding)
GO:0004601 (peroxidase activity)
GO:0008201 (heparin binding)
GO:0016491 (oxidoreductase activity)
GO:0020037 (heme binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0001878 (response to yeast)
GO:0002149 (hypochlorous acid biosynthetic process)
GO:0002679 (respiratory burst involved in defense response)
GO:0006952 (defense response)
GO:0006979 (response to oxidative stress)
GO:0007568 (aging)
GO:0009612 (response to mechanical stimulus)
GO:0019430 (removal of superoxide radicals)
GO:0032094 (response to food)
GO:0032496 (response to lipopolysaccharide)
GO:0034374 (low-density lipoprotein particle remodeling)
GO:0042744 (hydrogen peroxide catabolic process)
GO:0043066 (negative regulation of apoptotic process)
GO:0044130 (negative regulation of growth of symbiont in host)
GO:0050832 (defense response to fungus)
GO:0055114 (oxidation-reduction process)
GO:1990268 (response to gold nanoparticle)
Wikipedia Myeloperoxidase

Target Cross References - Protein

canSAR P05164
CGD Myeloperoxidase deficiency
Human Protein Atlas ENSG00000005381
IntAct P05164
Guide to Pharmacology 2789
Open Targets ENSG00000005381
PharmGKB PA243
UniProt A1L4B8 P05164 Q14862 Q4PJH5 Q9UCL7

Target Cross References - Domain

InterPro IPR010255 (Haem_peroxidase.)
IPR019791 (Haem_peroxidase_animal.)
IPR029609 (MPO.)
Pfam PF03098 (An_peroxidase)

Target Cross References - Structure

PDBe 1CXP 1D2V 1D5L 1D7W 1DNU 1DNW 1MHL 1MYP 3F9P 3ZS0 3ZS1 4C1M 4DL1 4EJX 5FIW
CREDO 1CXP 1D2V 1D5L 1D7W 1DNU 1DNW 1MHL 1MYP 3F9P 3ZS0 3ZS1 4C1M 4DL1 4EJX 5FIW
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