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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2439
Target Type SINGLE PROTEIN
Preferred Name Myeloperoxidase
Synonyms 84 kDa myeloperoxidase | 89 kDa myeloperoxidase | MPO | MPO | Myeloperoxidase | Myeloperoxidase heavy chain | Myeloperoxidase light chain
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Myeloperoxidase SINGLE PROTEIN P05164

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000005381
Ensembl ENSG00000005381
GO Cellular Component GO:0005615 (extracellular space)
GO:0005634 (nucleus)
GO:0005764 (lysosome)
GO:0030141 (stored secretory granule)
GO Molecular Function GO:0003682 (chromatin binding)
GO:0004601 (peroxidase activity)
GO:0008201 (heparin binding)
GO:0020037 (heme binding)
GO Biological Process GO:0006916 (anti-apoptosis)
GO:0034374 (low-density lipoprotein particle remodeling)
GO:0042744 (hydrogen peroxide catabolic process)
Wikipedia Myeloperoxidase

Target Cross References - Protein

canSAR P05164
CGD Myeloperoxidase deficiency
Human Protein Atlas ENSG00000005381
Guide to Pharmacology 2789 (myeloperoxidase)
PharmGKB PA243
UniProt A1L4B8 P05164 Q14862 Q4PJH5 Q9UCL7

Target Cross References - Domain

InterPro IPR002007 (Haem_peroxidase_animal.)
IPR010255 (Haem_peroxidase.)
IPR019791 (Haem_peroxidase_animal_subgr.)
Pfam PF03098 (An_peroxidase)

Target Cross References - Structure

PDBe 1CXP 1D2V 1D5L 1D7W 1DNU 1DNW 1MHL 1MYP 3F9P
CREDO 1CXP 1D2V 1D5L 1D7W 1DNU 1DNW 1MHL 1MYP 3F9P
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