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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2438
Preferred Name Eosinophil peroxidase
Synonyms EPER | EPO | EPO | EPP | EPX | Eosinophil peroxidase heavy chain | Eosinophil peroxidase light chain | Eosinophil peroxidase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Eosinophil peroxidase SINGLE PROTEIN P11678

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000121053
Ensembl ENSG00000121053
GO Cellular Component GO:0070062 (extracellular exosome)
GO Molecular Function GO:0004601 (peroxidase activity)
GO:0016491 (oxidoreductase activity)
GO:0020037 (heme binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0002215 (defense response to nematode)
GO:0006952 (defense response)
GO:0006979 (response to oxidative stress)
GO:0032693 (negative regulation of interleukin-10 production)
GO:0032714 (negative regulation of interleukin-5 production)
GO:0032753 (positive regulation of interleukin-4 production)
GO:0042744 (hydrogen peroxide catabolic process)
GO:0055114 (oxidation-reduction process)
GO:0072677 (eosinophil migration)
GO:0098869 (cellular oxidant detoxification)
Wikipedia Eosinophil_peroxidase

Target Cross References - Protein

canSAR P11678
CGD Eosinophil peroxidase deficiency
Human Protein Atlas ENSG00000121053
IntAct P11678
Open Targets ENSG00000121053
PharmGKB PA27841
Reactome R-HSA-6798695 (Neutrophil degranulation.)
UniProt P11678 Q4TVP3

Target Cross References - Domain

InterPro IPR010255 (Haem_peroxidase.)
IPR019791 (Haem_peroxidase_animal.)
IPR029599 (EPX/EPO.)
Pfam PF03098 (An_peroxidase)