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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2437
Target Type SINGLE PROTEIN
Preferred Name Protein phosphatase 2C alpha
Synonyms PP2C-alpha | PPM1A | PPPM1A | Protein phosphatase 1A | Protein phosphatase 2C isoform alpha | Protein phosphatase IA
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > phosphatase > protein phosphatase > serine/threonine protein phosphatase

Target Components

Component Description Relationship Accession
Protein phosphatase 1A SINGLE PROTEIN P35813

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000100614
Ensembl ENSG00000100614
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0016020 (membrane)
GO Molecular Function GO:0000287 (magnesium ion binding)
GO:0003824 (catalytic activity)
GO:0004721 (phosphoprotein phosphatase activity)
GO:0004722 (protein serine/threonine phosphatase activity)
GO:0004871 (signal transducer activity)
GO:0005515 (protein binding)
GO:0016787 (hydrolase activity)
GO:0030145 (manganese ion binding)
GO:0033192 (calmodulin-dependent protein phosphatase activity)
GO:0043169 (cation binding)
GO:0046872 (metal ion binding)
GO:0070412 (R-SMAD binding)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0006470 (protein dephosphorylation)
GO:0006499 (N-terminal protein myristoylation)
GO:0007050 (cell cycle arrest)
GO:0010991 (negative regulation of SMAD protein complex assembly)
GO:0016055 (Wnt signaling pathway)
GO:0016311 (dephosphorylation)
GO:0030177 (positive regulation of Wnt signaling pathway)
GO:0030512 (negative regulation of transforming growth factor beta receptor signaling pathway)
GO:0030514 (negative regulation of BMP signaling pathway)
GO:0035970 (peptidyl-threonine dephosphorylation)
GO:0042347 (negative regulation of NF-kappaB import into nucleus)
GO:0043123 (positive regulation of I-kappaB kinase/NF-kappaB signaling)
GO:0043124 (negative regulation of I-kappaB kinase/NF-kappaB signaling)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0046827 (positive regulation of protein export from nucleus)
GO:0071560 (cellular response to transforming growth factor beta stimulus)
Wikipedia PPM1A

Target Cross References - Protein

canSAR P35813
Human Protein Atlas ENSG00000100614
IntAct P35813
Open Targets ENSG00000100614
PharmGKB PA33603
Reactome R-HSA-2173795 (Downregulation of SMAD2/3:SMAD4 transcriptional activity.)
R-HSA-380972 (Energy dependent regulation of mTOR by LKB1-AMPK.)
UniProt B5BU11 J3KNM0 O75551 P35813

Target Cross References - Domain

InterPro IPR000222 (PP2C_BS.)
IPR001932 (PPM-type_phosphatase_dom.)
IPR012911 (PP2C_C.)
IPR015655 (PP2C.)
Pfam PF00481 (PP2C)
PF07830 (PP2C_C)

Target Cross References - Structure

PDBe 1A6Q 3FXJ 3FXK 3FXL 3FXM 3FXO 4RA2 4RAF 4RAG
CREDO 1A6Q 3FXJ 3FXK 3FXL 3FXM 3FXO 4RA2 4RAF 4RAG
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