ChEMBL logo


ChEMBL Statistics
  Loading Statistics...

Target Report Card

Target Name and Classification

Target ID CHEMBL2434
Preferred Name Interleukin-8 receptor B
Synonyms C-X-C chemokine receptor type 2 | CD_antigen=CD182 | CDw128b | CXC-R2 | CXCR-2 | CXCR2 | GRO/MGSA receptor | High affinity interleukin-8 receptor B | IL-8 receptor type 2 | IL-8R B | IL8RB
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > peptide receptor (family a gpcr) > chemokine receptor > cxc chemokine receptor

Target Components

Component Description Relationship Accession
C-X-C chemokine receptor type 2 SINGLE PROTEIN P25025

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2096909 Interleukin-8 receptors, CXCR1/CXCR2 PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL191413 REPARIXIN Interleukin-8 receptor B modulator 3 PubMed PubMed
CHEMBL189475 Ladarixin Interleukin-8 receptor B modulator 2 PubMed
CHEMBL216981 NAVARIXIN Interleukin-8 receptor B antagonist 2 ClinicalTrials PubMed
CHEMBL2103864 NAVARIXIN HYDRATE Interleukin-8 receptor B antagonist 2 PubMed PubMed
CHEMBL2178579 ELUBRIXIN Interleukin-8 receptor B antagonist 2 PubMed
CHEMBL3039531 DANIRIXIN Interleukin-8 receptor B antagonist 2 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000180871
Ensembl ENSG00000180871
GO Cellular Component GO:0005622 (intracellular)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0042629 (mast cell granule)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004918 (interleukin-8 receptor activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0005515 (protein binding)
GO:0016494 (C-X-C chemokine receptor activity)
GO:0019959 (interleukin-8 binding)
GO Biological Process GO:0002407 (dendritic cell chemotaxis)
GO:0006935 (chemotaxis)
GO:0006954 (inflammatory response)
GO:0006968 (cellular defense response)
GO:0007165 (signal transduction)
GO:0007166 (cell surface receptor signaling pathway)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007200 (phospholipase C-activating G-protein coupled receptor signaling pathway)
GO:0008284 (positive regulation of cell proliferation)
GO:0030593 (neutrophil chemotaxis)
GO:0031623 (receptor internalization)
GO:0038112 (interleukin-8-mediated signaling pathway)
GO:0042119 (neutrophil activation)
GO:0070098 (chemokine-mediated signaling pathway)
Wikipedia Interleukin_8_receptor,_beta

Target Cross References - Protein

canSAR P25025
Human Protein Atlas ENSG00000180871
IntAct P25025
Guide to Pharmacology 69
Open Targets ENSG00000180871
PharmGKB PA29843
Pharos P25025 (Tchem)
Reactome R-HSA-380108 (Chemokine receptors bind chemokines.)
R-HSA-418594 (G alpha (i) signalling events.)
R-HSA-6798695 (Neutrophil degranulation.)
UniProt P25025 Q8IUZ1 Q9P2T6 Q9P2T7

Target Cross References - Domain

InterPro IPR000057 (Chemokine_CXCR2.)
IPR000174 (Chemokine_CXCR_1/2.)
IPR000276 (GPCR_Rhodpsn.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)

Target Cross References - Structure