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Target Report Card

Target Name and Classification

Target ID CHEMBL2433
Preferred Name Prohormone convertase 2
Synonyms KEX2-like endoprotease 2 | NEC 2 | NEC2 | Neuroendocrine convertase 2 | PC2 | PCSK2 | Prohormone convertase 2 | Proprotein convertase 2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > serine protease > serine protease sb clan > serine protease s8b subfamily

Target Components

Component Description Relationship Accession
Neuroendocrine convertase 2 SINGLE PROTEIN P16519

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000125851
Ensembl ENSG00000125851
GO Cellular Component GO:0005615 (extracellular space)
GO:0016020 (membrane)
GO:0030133 (transport vesicle)
GO:0030141 (secretory granule)
GO:0030425 (dendrite)
GO:0031410 (cytoplasmic vesicle)
GO:0034774 (secretory granule lumen)
GO:0043025 (neuronal cell body)
GO:0043204 (perikaryon)
GO Molecular Function GO:0004175 (endopeptidase activity)
GO:0004252 (serine-type endopeptidase activity)
GO:0005515 (protein binding)
GO:0008233 (peptidase activity)
GO:0008236 (serine-type peptidase activity)
GO:0016787 (hydrolase activity)
GO:0032403 (protein complex binding)
GO Biological Process GO:0006508 (proteolysis)
GO:0007399 (nervous system development)
GO:0016485 (protein processing)
GO:0016486 (peptide hormone processing)
GO:0016540 (protein autoprocessing)
GO:0030070 (insulin processing)
GO:0034230 (enkephalin processing)
GO:0034231 (islet amyloid polypeptide processing)
Wikipedia Proprotein_convertase_2

Target Cross References - Protein

canSAR P16519
Human Protein Atlas ENSG00000125851
Guide to Pharmacology 2383
Open Targets ENSG00000125851
PharmGKB PA33091
Reactome R-HSA-264876 (Insulin processing.)
UniProt B1ANH9 B4DFQ3 P16519 Q14927 Q5JYQ1 Q8IWA8 Q9NQG3 Q9NUG1 Q9UJC6

Target Cross References - Domain

InterPro IPR000209 (Peptidase_S8/S53_dom.)
IPR002884 (PrprotnconvertsP.)
IPR008979 (Galactose-bd-like.)
IPR009020 (Propept_inh.)
IPR015500 (Peptidase_S8_subtilisin-rel.)
IPR022398 (Peptidase_S8_His-AS.)
IPR023827 (Peptidase_S8_Asp-AS.)
IPR023828 (Peptidase_S8_Ser-AS.)
IPR032815 (S8_pro-domain.)
IPR034182 (Kexin/furin.)
Pfam PF00082 (Peptidase_S8)
PF01483 (P_proprotein)
PF16470 (S8_pro-domain)