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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2433
Target Type SINGLE PROTEIN
Preferred Name Prohormone convertase 2
Synonyms KEX2-like endoprotease 2 | NEC 2 | NEC2 | Neuroendocrine convertase 2 | PC2 | PCSK2 | Prohormone convertase 2 | Proprotein convertase 2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > serine protease > serine protease sb clan > serine protease s8b subfamily

Target Components

Component Description Relationship Accession
Neuroendocrine convertase 2 SINGLE PROTEIN P16519

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000125851
Ensembl ENSG00000125851
GO Cellular Component GO:0005615 (extracellular space)
GO:0005625 (soluble fraction)
GO:0016020 (membrane)
GO:0030133 (transport vesicle)
GO Molecular Function GO:0004252 (serine-type endopeptidase activity)
GO Biological Process GO:0030070 (insulin processing)
GO:0034230 (enkephalin processing)
GO:0034231 (islet amyloid polypeptide processing)
Wikipedia Proprotein_convertase_2

Target Cross References - Protein

canSAR P16519
Human Protein Atlas ENSG00000125851
Guide to Pharmacology 2383 (proprotein convertase subtilisin/kexin type 2)
PharmGKB PA33091
Reactome REACT_15380 (Diabetes pathways.)
UniProt P16519 Q14927 Q9NQG3 Q9NUG1 Q9UJC6

Target Cross References - Domain

InterPro IPR000209 (Peptidase_S8/S53.)
IPR002884 (PrprotnconvertsP.)
IPR008979 (Galactose-bd-like.)
IPR009020 (Prot_inh_propept.)
IPR015500 (Peptidase_S8_subtilisin-rel.)
IPR022398 (Peptidase_S8_His-AS.)
IPR023827 (Peptidase_S8_Asp-AS.)
IPR023828 (Peptidase_S8_Ser-AS.)
Pfam PF00082 (Peptidase_S8)
PF01483 (P_proprotein)
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