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Target Report Card

Target Name and Classification

Target ID CHEMBL2428
Preferred Name Myosin light chain kinase, smooth muscle
Synonyms KRP | Kinase-related protein | MLCK | MLCK | MLCK1 | MYLK | MYLK1 | Myosin light chain kinase, smooth muscle | Myosin light chain kinase, smooth muscle, deglutamylated form | Telokin | smMLCK
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > camk protein kinase group > camk protein kinase mlck family

Target Components

Component Description Relationship Accession
Myosin light chain kinase, smooth muscle SINGLE PROTEIN Q15746

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000065534
Ensembl ENSG00000065534
GO Cellular Component GO:0001725 (stress fiber)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005856 (cytoskeleton)
GO:0030027 (lamellipodium)
GO:0032154 (cleavage furrow)
GO:0042995 (cell projection)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0003779 (actin binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004687 (myosin light chain kinase activity)
GO:0005515 (protein binding)
GO:0005516 (calmodulin binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0002230 (positive regulation of defense response to virus by host)
GO:0006468 (protein phosphorylation)
GO:0006936 (muscle contraction)
GO:0006939 (smooth muscle contraction)
GO:0014820 (tonic smooth muscle contraction)
GO:0016310 (phosphorylation)
GO:0030335 (positive regulation of cell migration)
GO:0032060 (bleb assembly)
GO:0051928 (positive regulation of calcium ion transport)
GO:0060414 (aorta smooth muscle tissue morphogenesis)
GO:0071476 (cellular hypotonic response)
GO:0090303 (positive regulation of wound healing)
GO:0098779 (mitophagy in response to mitochondrial depolarization)
GO:0098792 (xenophagy)
Wikipedia MYLK

Target Cross References - Protein

CGD Aortic aneurysm, familial thoracic 7
Human Protein Atlas ENSG00000065534
IntAct Q15746
Guide to Pharmacology 1552
Open Targets ENSG00000065534
PharmGKB PA31388
Pharos Q15746 (Tchem)
Reactome R-HSA-445355 (Smooth Muscle Contraction.)
R-HSA-5627123 (RHO GTPases activate PAKs.)
UniProt B4DUE3 D3DN97 O95796 O95797 O95798 O95799 Q14844 Q15746 Q16794 Q17S15 Q3ZCP9 Q5MY99 Q5MYA0 Q6P2N0 Q7Z4J0 Q9C0L5 Q9UBG5 Q9UBY6 Q9UIT9

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR003598 (Ig_sub2.)
IPR003599 (Ig_sub.)
IPR003961 (FN3_dom.)
IPR007110 (Ig-like_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR013098 (Ig_I-set.)
IPR013783 (Ig-like_fold.)
IPR015725 (Telokin/Myosin_light_ch_kin.)
IPR017441 (Protein_kinase_ATP_BS.)
Pfam PF00041 (fn3)
PF00069 (Pkinase)
PF07679 (I-set)