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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2424
Target Type SINGLE PROTEIN
Preferred Name Glyoxalase I
Synonyms Aldoketomutase | GLO1 | Glx I | Glyoxalase I | Ketone-aldehyde mutase | Lactoylglutathione lyase | Methylglyoxalase | S-D-lactoylglutathione methylglyoxal lyase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Lactoylglutathione lyase SINGLE PROTEIN Q04760

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000124767
Ensembl ENSG00000124767
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0004462 (lactoylglutathione lyase activity)
GO:0008270 (zinc ion binding)
GO:0016829 (lyase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0005975 (carbohydrate metabolic process)
GO:0006090 (pyruvate metabolic process)
GO:0006357 (regulation of transcription from RNA polymerase II promoter)
GO:0006749 (glutathione metabolic process)
GO:0009438 (methylglyoxal metabolic process)
GO:0030316 (osteoclast differentiation)
GO:0043066 (negative regulation of apoptotic process)
Wikipedia GLO1

Target Cross References - Protein

canSAR Q04760
Human Protein Atlas ENSG00000124767
IntAct Q04760
Open Targets ENSG00000124767
PharmGKB PA28724
Reactome R-HSA-70268 (Pyruvate metabolism.)
UniProt B2R6P7 B4DDV0 P78375 Q04760 Q59EL0 Q5TZW3 Q96FC0 Q96J41

Target Cross References - Domain

InterPro IPR004360 (Glyas_Fos-R_dOase_dom.)
IPR004361 (Glyoxalase_1.)
IPR018146 (Glyoxalase_1_CS.)
IPR029068 (Glyas_Bleomycin-R_OHBP_Dase.)
Pfam PF00903 (Glyoxalase)

Target Cross References - Structure

PDBe 1BH5 1FRO 1QIN 1QIP 3VW9 3W0T 3W0U
CREDO 1BH5 1FRO 1QIN 1QIP 3VW9 3W0T 3W0U
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