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Target Report Card

Target Name and Classification

Target ID CHEMBL242
Preferred Name Estrogen receptor beta
Synonyms ER-beta | ESR2 | ESTRB | Estrogen receptor beta | NR3A2 | Nuclear receptor subfamily 3 group A member 2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transcription factor > nuclear receptor > nuclear hormone receptor subfamily 3 > nuclear hormone receptor subfamily 3 group a > nuclear hormone receptor subfamily 3 group a member 2

Target Components

Component Description Relationship Accession
Estrogen receptor beta SINGLE PROTEIN Q92731

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2093866 Estrogen receptor PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1116 RALOXIFENE HYDROCHLORIDE Estrogen receptor beta modulator 4 DailyMed
CHEMBL1200721 ESTRAMUSTINE PHOSPHATE SODIUM Estrogen receptor beta 4 DailyMed PubMed
CHEMBL1200761 CHLOROTRIANISENE Estrogen receptor beta modulator 4 PubMed
CHEMBL3545411 MF101 Estrogen receptor beta agonist 3 PubMed
CHEMBL450940 PRINABEREL Estrogen receptor beta agonist 2 PubMed PubMed PubMed
CHEMBL198877 EQUOL Estrogen receptor beta agonist 2 Other
CHEMBL278703 ERTEBEREL Estrogen receptor beta agonist 2 Other PubMed
CHEMBL3545092 CR 1447 Estrogen receptor beta agonist 2 Other

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000140009
Ensembl ENSG00000140009
GO Cellular Component GO:0005576 (extracellular region)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005886 (plasma membrane)
GO:0005929 (cilium)
GO:0032993 (protein-DNA complex)
GO:0043005 (neuron projection)
GO:0043025 (neuronal cell body)
GO:0043204 (perikaryon)
GO:0048471 (perinuclear region of cytoplasm)
GO Molecular Function GO:0001046 (core promoter sequence-specific DNA binding)
GO:0003677 (DNA binding)
GO:0003700 (transcription factor activity, sequence-specific DNA binding)
GO:0003707 (steroid hormone receptor activity)
GO:0003713 (transcription coactivator activity)
GO:0004879 (RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding)
GO:0005496 (steroid binding)
GO:0005515 (protein binding)
GO:0008144 (drug binding)
GO:0008270 (zinc ion binding)
GO:0008289 (lipid binding)
GO:0019899 (enzyme binding)
GO:0030284 (estrogen receptor activity)
GO:0034056 (estrogen response element binding)
GO:0038052 (RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding)
GO:0042562 (hormone binding)
GO:0042975 (peroxisome proliferator activated receptor binding)
GO:0043565 (sequence-specific DNA binding)
GO:0046872 (metal ion binding)
GO:0048019 (receptor antagonist activity)
GO:1903924 (estradiol binding)
GO:1990239 (steroid hormone binding)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0001541 (ovarian follicle development)
GO:0001662 (behavioral fear response)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006367 (transcription initiation from RNA polymerase II promoter)
GO:0007165 (signal transduction)
GO:0007267 (cell-cell signaling)
GO:0007611 (learning or memory)
GO:0008584 (male gonad development)
GO:0008585 (female gonad development)
GO:0009414 (response to water deprivation)
GO:0009725 (response to hormone)
GO:0014070 (response to organic cyclic compound)
GO:0014823 (response to activity)
GO:0017085 (response to insecticide)
GO:0021549 (cerebellum development)
GO:0021764 (amygdala development)
GO:0021854 (hypothalamus development)
GO:0030308 (negative regulation of cell growth)
GO:0030518 (intracellular steroid hormone receptor signaling pathway)
GO:0030520 (intracellular estrogen receptor signaling pathway)
GO:0030850 (prostate gland development)
GO:0031667 (response to nutrient levels)
GO:0032355 (response to estradiol)
GO:0033574 (response to testosterone)
GO:0033595 (response to genistein)
GO:0035690 (cellular response to drug)
GO:0042493 (response to drug)
GO:0043065 (positive regulation of apoptotic process)
GO:0043401 (steroid hormone mediated signaling pathway)
GO:0043523 (regulation of neuron apoptotic process)
GO:0043627 (response to estrogen)
GO:0044752 (response to human chorionic gonadotropin)
GO:0044849 (estrous cycle)
GO:0045471 (response to ethanol)
GO:0045742 (positive regulation of epidermal growth factor receptor signaling pathway)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0045909 (positive regulation of vasodilation)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0048521 (negative regulation of behavior)
GO:0048662 (negative regulation of smooth muscle cell proliferation)
GO:0050680 (negative regulation of epithelial cell proliferation)
GO:0051091 (positive regulation of sequence-specific DNA binding transcription factor activity)
GO:0060009 (Sertoli cell development)
GO:0060011 (Sertoli cell proliferation)
GO:0060548 (negative regulation of cell death)
GO:0070374 (positive regulation of ERK1 and ERK2 cascade)
GO:0071259 (cellular response to magnetism)
GO:0071392 (cellular response to estradiol stimulus)
GO:0071407 (cellular response to organic cyclic compound)
GO:0071548 (response to dexamethasone)
GO:1900116 (extracellular negative regulation of signal transduction)
GO:1901215 (negative regulation of neuron death)
GO:1902074 (response to salt)
GO:1903925 (response to bisphenol A)
GO:2000252 (negative regulation of feeding behavior)
GO:2000378 (negative regulation of reactive oxygen species metabolic process)
Wikipedia Estrogen_receptor_beta

Target Cross References - Protein

canSAR Q92731
Human Protein Atlas ENSG00000140009
IntAct Q92731
Guide to Pharmacology 621
Open Targets ENSG00000140009
PharmGKB PA27886
Pharos Q92731 (Tclin)
Reactome R-HSA-383280 (Nuclear Receptor transcription pathway.)
UniProt A8K8K5 G3V5M5 O60608 O60685 O60702 O60703 O75583 O75584 Q0MWT5 Q0MWT6 Q86Z31 Q92731 Q9UEV6 Q9UHD3 Q9UQK9

Target Cross References - Domain

InterPro IPR000536 (Nucl_hrmn_rcpt_lig-bd.)
IPR001628 (Znf_hrmn_rcpt.)
IPR001723 (Nuclear_hrmn_rcpt.)
IPR013088 (Znf_NHR/GATA.)
IPR021064 (Estrogen_rcpt_beta_N.)
IPR024178 (Oest_rcpt/oest-rel_rcp.)
IPR028355 (ER-beta/gamma.)
Pfam PF00104 (Hormone_recep)
PF00105 (zf-C4)
PF12497 (ERbeta_N)

Target Cross References - Structure

PDBe 1L2J 1NDE 1QKM 1U3Q 1U3R 1U3S 1U9E 1X76 1X78 1X7B 1X7J 1YY4 1YYE 1ZAF 2FSZ 2GIU 2I0G 2JJ3 2NV7 2QTU 2YJD 2YLY 2Z4B 3OLL More...
CREDO 1L2J 1NDE 1QKM 1U3Q 1U3R 1U3S 1U9E 1X76 1X78 1X7B 1X7J 1YY4 1YYE 1ZAF 2FSZ 2GIU 2I0G 2JJ3 2NV7 2QTU 2YJD 2YLY 2Z4B 3OLL More...