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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2414
Preferred Name C-C chemokine receptor type 4
Synonyms C-C CKR-4 | C-C chemokine receptor type 4 | CC-CKR-4 | CCR-4 | CCR4 | CCR4 | CD_antigen=CD194 | CMKBR4 | K5-5
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > peptide receptor (family a gpcr) > chemokine receptor > cc chemokine receptor

Target Components

Component Description Relationship Accession
C-C chemokine receptor type 4 SINGLE PROTEIN P51679

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1743041 MOGAMULIZUMAB C-C chemokine receptor type 4 cross-linking agent 3 PubMed PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000183813
Ensembl ENSG00000183813
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0009897 (external side of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0043025 (neuronal cell body)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004950 (chemokine receptor activity)
GO:0016493 (C-C chemokine receptor activity)
GO Biological Process GO:0001764 (neuron migration)
GO:0002507 (tolerance induction)
GO:0006935 (chemotaxis)
GO:0006954 (inflammatory response)
GO:0006955 (immune response)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007204 (positive regulation of cytosolic calcium ion concentration)
GO:0009314 (response to radiation)
GO:0009617 (response to bacterium)
GO:0046677 (response to antibiotic)
GO:0048872 (homeostasis of number of cells)
GO:0050927 (positive regulation of positive chemotaxis)
GO:0070098 (chemokine-mediated signaling pathway)
Wikipedia CCR4

Target Cross References - Protein

canSAR P51679
Human Protein Atlas ENSG00000183813
IntAct P51679
Guide to Pharmacology 61
Open Targets ENSG00000183813
PharmGKB PA26169
Pharos P51679 (Tclin)
Reactome R-HSA-380108 (Chemokine receptors bind chemokines.)
R-HSA-418594 (G alpha (i) signalling events.)
UniProt P51679 Q9ULY6 Q9ULY7

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000355 (Chemokine_rcpt.)
IPR002239 (Chemokine_CCR4.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)