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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2413
Target Type SINGLE PROTEIN
Preferred Name C-C chemokine receptor type 1
Synonyms C-C CKR-1 | C-C chemokine receptor type 1 | CC-CKR-1 | CCR-1 | CCR1 | CCR1 | CD_antigen=CD191 | CMKBR1 | CMKR1 | HM145 | LD78 receptor | MIP-1alpha-R | Macrophage inflammatory protein 1-alpha receptor | RANTES-R | SCYAR1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > peptide receptor (family a gpcr) > chemokine receptor > cc chemokine receptor

Target Components

Component Description Relationship Accession
C-C chemokine receptor type 1 SINGLE PROTEIN P32246

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL2178570 AZD4818 C-C chemokine receptor type 1 antagonist 2 PubMed
CHEMBL3545404 CCX354 C-C chemokine receptor type 1 antagonist 2 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000163823
Ensembl ENSG00000163823
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0009897 (external side of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0004435 (phosphatidylinositol phospholipase C activity)
GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004950 (chemokine receptor activity)
GO:0005515 (protein binding)
GO:0016493 (C-C chemokine receptor activity)
GO:0019957 (C-C chemokine binding)
GO:0035717 (chemokine (C-C motif) ligand 7 binding)
GO:0071791 (chemokine (C-C motif) ligand 5 binding)
GO Biological Process GO:0002407 (dendritic cell chemotaxis)
GO:0006816 (calcium ion transport)
GO:0006874 (cellular calcium ion homeostasis)
GO:0006887 (exocytosis)
GO:0006935 (chemotaxis)
GO:0006954 (inflammatory response)
GO:0006955 (immune response)
GO:0007155 (cell adhesion)
GO:0007165 (signal transduction)
GO:0007166 (cell surface receptor signaling pathway)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007187 (G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)
GO:0007204 (positive regulation of cytosolic calcium ion concentration)
GO:0007267 (cell-cell signaling)
GO:0009611 (response to wounding)
GO:0010629 (negative regulation of gene expression)
GO:0019221 (cytokine-mediated signaling pathway)
GO:0030335 (positive regulation of cell migration)
GO:0030502 (negative regulation of bone mineralization)
GO:0045672 (positive regulation of osteoclast differentiation)
GO:0051928 (positive regulation of calcium ion transport)
GO:0070098 (chemokine-mediated signaling pathway)
GO:0070374 (positive regulation of ERK1 and ERK2 cascade)
GO:0090026 (positive regulation of monocyte chemotaxis)
Wikipedia CCR1

Target Cross References - Protein

canSAR P32246
Human Protein Atlas ENSG00000163823
IntAct P32246
Guide to Pharmacology 58
Open Targets ENSG00000163823
PharmGKB PA26166
Pharos P32246 (Tchem)
Reactome R-HSA-380108 (Chemokine receptors bind chemokines.)
R-HSA-418594 (G alpha (i) signalling events.)
R-HSA-6783783 (Interleukin-10 signaling.)
UniProt P32246 Q86VA9

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000355 (Chemokine_rcpt.)
IPR002236 (Chemokine_CCR1.)
IPR017452 (GPCR_Rhodpsn_7TM.)
IPR034321 (Chemokine_CCR1_euk.)
Pfam PF00001 (7tm_1)
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