ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL2412
Target Type SINGLE PROTEIN
Preferred Name G2/mitotic-specific cyclin B1
Synonyms CCNB | CCNB1 | G2/mitotic-specific cyclin-B1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • other cytosolic protein

Target Components

Component Description Relationship Accession
G2/mitotic-specific cyclin-B1 SINGLE PROTEIN P14635

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL1907602 Cyclin-dependent kinase 1/cyclin B1 PROTEIN COMPLEX
CHEMBL2094127 Cyclin-dependent kinase 1/cyclin B PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000134057
Ensembl ENSG00000134057
GO Cellular Component GO:0000922 (spindle pole)
GO:0000942 (condensed nuclear chromosome outer kinetochore)
GO:0005654 (nucleoplasm)
GO:0005815 (microtubule organizing center)
GO:0005829 (cytosol)
GO Biological Process GO:0000079 (regulation of cyclin-dependent protein kinase activity)
GO:0000082 (G1/S transition of mitotic cell cycle)
GO:0000086 (G2/M transition of mitotic cell cycle)
GO:0000236 (mitotic prometaphase)
GO:0007080 (mitotic metaphase plate congression)
GO:0031145 (anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process)
GO:0043148 (mitotic spindle stabilization)
GO:0045931 (positive regulation of mitotic cell cycle)
GO:0051301 (cell division)
GO:0051437 (positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle)
GO:0051987 (positive regulation of attachment of spindle microtubules to kinetochore)
GO:0071174 (mitotic cell cycle spindle checkpoint)
Wikipedia Cyclin_B1

Target Cross References - Protein

canSAR P14635
Human Protein Atlas ENSG00000134057
IntAct P14635
PharmGKB PA95
Reactome REACT_152 (Cell Cycle, Mitotic.)
REACT_1538 (Cell Cycle Checkpoints.)
UniProt P14635

Target Cross References - Domain

InterPro IPR004367 (Cyclin_C.)
IPR006671 (Cyclin_N.)
IPR013763 (Cyclin-like.)
IPR014400 (Cyclin_A/B/D/E.)
Pfam PF00134 (Cyclin_N)
PF02984 (Cyclin_C)

Target Cross References - Structure

PDBe 2B9R 2JGZ
CREDO 2B9R 2JGZ
spacer
spacer