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Target Report Card

Target Name and Classification

Target ID CHEMBL2412
Preferred Name G2/mitotic-specific cyclin B1
Synonyms CCNB | CCNB1 | G2/mitotic-specific cyclin-B1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • other cytosolic protein

Target Components

Component Description Relationship Accession
G2/mitotic-specific cyclin-B1 SINGLE PROTEIN P14635

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL1907602 Cyclin-dependent kinase 1/cyclin B1 PROTEIN COMPLEX
CHEMBL2094127 Cyclin-dependent kinase 1/cyclin B PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000134057
Ensembl ENSG00000134057
GO Cellular Component GO:0000922 (spindle pole)
GO:0000942 (condensed nuclear chromosome outer kinetochore)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005813 (centrosome)
GO:0005815 (microtubule organizing center)
GO:0005829 (cytosol)
GO:0005856 (cytoskeleton)
GO:0016020 (membrane)
GO Molecular Function GO:0004693 (cyclin-dependent protein serine/threonine kinase activity)
GO:0005113 (patched binding)
GO:0005515 (protein binding)
GO:0016301 (kinase activity)
GO:0019901 (protein kinase binding)
GO:0035173 (histone kinase activity)
GO Biological Process GO:0000086 (G2/M transition of mitotic cell cycle)
GO:0000278 (mitotic cell cycle)
GO:0001556 (oocyte maturation)
GO:0001701 (in utero embryonic development)
GO:0001933 (negative regulation of protein phosphorylation)
GO:0006461 (protein complex assembly)
GO:0006468 (protein phosphorylation)
GO:0006977 (DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)
GO:0007049 (cell cycle)
GO:0007052 (mitotic spindle organization)
GO:0007067 (mitotic nuclear division)
GO:0007077 (mitotic nuclear envelope disassembly)
GO:0007080 (mitotic metaphase plate congression)
GO:0007283 (spermatogenesis)
GO:0009612 (response to mechanical stimulus)
GO:0009636 (response to toxic substance)
GO:0010629 (negative regulation of gene expression)
GO:0031145 (anaphase-promoting complex-dependent catabolic process)
GO:0031442 (positive regulation of mRNA 3'-end processing)
GO:0033129 (positive regulation of histone phosphorylation)
GO:0042246 (tissue regeneration)
GO:0042493 (response to drug)
GO:0042787 (protein ubiquitination involved in ubiquitin-dependent protein catabolic process)
GO:0045787 (positive regulation of cell cycle)
GO:0045931 (positive regulation of mitotic cell cycle)
GO:0046680 (response to DDT)
GO:0048146 (positive regulation of fibroblast proliferation)
GO:0048565 (digestive tract development)
GO:0051301 (cell division)
GO:0051436 (negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle)
GO:0051437 (positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition)
GO:0051439 (regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle)
GO:0051726 (regulation of cell cycle)
GO:0051987 (positive regulation of attachment of spindle microtubules to kinetochore)
GO:0055015 (ventricular cardiac muscle cell development)
GO:0060045 (positive regulation of cardiac muscle cell proliferation)
GO:0060623 (regulation of chromosome condensation)
GO:0071283 (cellular response to iron(III) ion)
GO:0071398 (cellular response to fatty acid)
GO:0071407 (cellular response to organic cyclic compound)
GO:0071456 (cellular response to hypoxia)
GO:0090266 (regulation of mitotic cell cycle spindle assembly checkpoint)
GO:2000775 (histone H3-S10 phosphorylation involved in chromosome condensation)
Wikipedia Cyclin_B1

Target Cross References - Protein

canSAR P14635
Human Protein Atlas ENSG00000134057
IntAct P14635
Open Targets ENSG00000134057
PharmGKB PA95
Reactome R-HSA-113507 (E2F-enabled inhibition of pre-replication complex formation.)
R-HSA-156711 (Polo-like kinase mediated events.)
R-HSA-162658 (Golgi Cisternae Pericentriolar Stack Reorganization.)
R-HSA-174048 (APC/C:Cdc20 mediated degradation of Cyclin B.)
R-HSA-176408 (Regulation of APC/C activators between G1/S and early anaphase.)
R-HSA-176412 (Phosphorylation of the APC/C.)
R-HSA-176417 (Phosphorylation of Emi1.)
R-HSA-2299718 (Condensation of Prophase Chromosomes.)
R-HSA-2465910 (MASTL Facilitates Mitotic Progression.)
R-HSA-2500257 (Resolution of Sister Chromatid Cohesion.)
R-HSA-2514853 (Condensation of Prometaphase Chromosomes.)
R-HSA-2565942 (Regulation of PLK1 Activity at G2/M Transition.)
R-HSA-2980767 (Activation of NIMA Kinases NEK9, NEK6, NEK7.)
R-HSA-3301854 (Nuclear Pore Complex (NPC) Disassembly.)
R-HSA-380320 (Recruitment of NuMA to mitotic centrosomes.)
R-HSA-4419969 (Depolymerisation of the Nuclear Lamina.)
R-HSA-6804114 (TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest.)
R-HSA-69273 (Cyclin A/B1 associated events during G2/M transition.)
R-HSA-69478 (G2/M DNA replication checkpoint.)
R-HSA-75035 (Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex.)
R-HSA-8852276 (The role of GTSE1 in G2/M progression after G2 checkpoint.)
UniProt A8K066 P14635 Q5TZP9

Target Cross References - Domain

InterPro IPR004367 (Cyclin_C-dom.)
IPR006671 (Cyclin_N.)
IPR013763 (Cyclin-like.)
Pfam PF00134 (Cyclin_N)
PF02984 (Cyclin_C)

Target Cross References - Structure

PDBe 2B9R 2JGZ 4Y72 4YC3 5HQ0
CREDO 2B9R 2JGZ 4Y72 4YC3 5HQ0