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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2409
Target Type SINGLE PROTEIN
Preferred Name Epoxide hydratase
Synonyms Bifunctional epoxide hydrolase 2 | CEH | Cytosolic epoxide hydrolase 2 | EPHX2 | Epoxide hydratase | Lipid-phosphate phosphatase | SEH | Soluble epoxide hydrolase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > serine protease > serine protease sc clan > serine protease s33 family

Target Components

Component Description Relationship Accession
Bifunctional epoxide hydrolase 2 SINGLE PROTEIN P34913

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000120915
Ensembl ENSG00000120915
GO Cellular Component GO:0005777 (peroxisome)
GO:0005829 (cytosol)
GO:0070062 (extracellular exosome)
GO:0005737 (cytoplasm)
GO Molecular Function GO:0000287 (magnesium ion binding)
GO:0005102 (receptor binding)
GO:0015643 (toxic substance binding)
GO:0033885 (10-hydroxy-9-(phosphonooxy)octadecanoate phosphatase activity)
GO:0042803 (protein homodimerization activity)
GO:0004301 (epoxide hydrolase activity)
GO:0042577 (lipid phosphatase activity)
GO:0016791 (phosphatase activity)
GO Biological Process GO:0045909 (positive regulation of vasodilation)
GO:0019369 (arachidonic acid metabolic process)
GO:0044281 (small molecule metabolic process)
GO:0006805 (xenobiotic metabolic process)
GO:0017144 (drug metabolic process)
GO:0042632 (cholesterol homeostasis)
GO:0072593 (reactive oxygen species metabolic process)
GO:0006874 (cellular calcium ion homeostasis)
GO:0006954 (inflammatory response)
GO:0008217 (regulation of blood pressure)
GO:0010628 (positive regulation of gene expression)
GO:0016311 (dephosphorylation)
GO:0046272 (stilbene catabolic process)
GO:0009636 (response to toxic substance)
GO:0019373 (epoxygenase P450 pathway)
GO:0046839 (phospholipid dephosphorylation)
GO:0090181 (regulation of cholesterol metabolic process)
Wikipedia Epoxide_hydrolase_2

Target Cross References - Protein

canSAR P34913
Human Protein Atlas ENSG00000120915
IntAct P34913
PharmGKB PA27830
UniProt P34913 Q9HBJ1 Q16764 Q9HBJ2 B2Z3B1

Target Cross References - Domain

InterPro IPR000639 (Epox_hydrolase-like.)
IPR023198 (PGP_dom2.)
IPR006439 (HAD-SF_hydro_IA.)
IPR011945 (HAD-SF_ppase_IA/epoxid_hydro_N.)
IPR023214 (HAD-like_dom.)
IPR000073 (AB_hydrolase_1.)
IPR029058 (AB_hydrolase.)
Pfam PF00561 (Abhydrolase_1)
PF13419 (HAD_2)

Target Cross References - Structure

PDBe 1ZD4 3WK5 3WKB 4JNC 4OCZ 4X6Y 4Y2T 5AM3 3ANS 3OTQ 3WK8 5AHX 5AI4 5AIA 5AK5 5AKE 5AKY 5ALF 5ALG 5ALJ 5ALK 5AM4 1ZD2 3WK6 More...
CREDO 1ZD4 3WK5 3WKB 4JNC 4OCZ 4X6Y 4Y2T 5AM3 3ANS 3OTQ 3WK8 5AHX 5AI4 5AIA 5AK5 5AKE 5AKY 5ALF 5ALG 5ALJ 5ALK 5AM4 1ZD2 3WK6 More...
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