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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2408
Target Type SINGLE PROTEIN
Preferred Name Cytochrome P450 2C18
Synonyms CYP2C18 | CYPIIC18 | Cytochrome P450 2C18 | Cytochrome P450-6b/29c
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > cytochrome p450 > cytochrome p450 family 2 > cytochrome p450 family 2c > cytochrome p450 2c18

Target Components

Component Description Relationship Accession
Cytochrome P450 2C18 SINGLE PROTEIN P33260

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000108242
Ensembl ENSG00000108242
GO Cellular Component GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0016020 (membrane)
GO:0031090 (organelle membrane)
GO:0043231 (intracellular membrane-bounded organelle)
GO Molecular Function GO:0004497 (monooxygenase activity)
GO:0005506 (iron ion binding)
GO:0008392 (arachidonic acid epoxygenase activity)
GO:0008395 (steroid hydroxylase activity)
GO:0016491 (oxidoreductase activity)
GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen)
GO:0019825 (oxygen binding)
GO:0020037 (heme binding)
GO:0046872 (metal ion binding)
GO:0070330 (aromatase activity)
GO Biological Process GO:0006805 (xenobiotic metabolic process)
GO:0019373 (epoxygenase P450 pathway)
GO:0055114 (oxidation-reduction process)
Wikipedia CYP2C18

Target Cross References - Protein

canSAR P33260
Human Protein Atlas ENSG00000108242
IntAct P33260
Guide to Pharmacology 1327
Open Targets ENSG00000108242
PharmGKB PA127
Reactome R-HSA-211981 (Xenobiotics.)
UniProt B2R8K2 P33260 Q16703 Q16751 Q4VAT5 Q6GRG1

Target Cross References - Domain

InterPro IPR001128 (Cyt_P450.)
IPR002401 (Cyt_P450_E_grp-I.)
IPR017972 (Cyt_P450_CS.)
Pfam PF00067 (p450)

Target Cross References - Structure

PDBe 2CIK 2H6P
CREDO 2CIK 2H6P
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