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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2393
Target Type SINGLE PROTEIN
Preferred Name AMP-activated protein kinase, gamma-1 subunit
Synonyms 5'-AMP-activated protein kinase subunit gamma-1 | AMPK gamma1 | AMPK subunit gamma-1 | AMPKg | PRKAG1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase regulatory subunit

Target Components

Component Description Relationship Accession
5'-AMP-activated protein kinase subunit gamma-1 SINGLE PROTEIN P54619

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3038453 AMPK alpha1/beta2/gamma1 PROTEIN COMPLEX
CHEMBL3038456 AMPK alpha2/beta2/gamma1 PROTEIN COMPLEX
CHEMBL2111345 AMP-activated protein kinase (AMPK) alpha-1/beta-1/gamma-1 PROTEIN COMPLEX
CHEMBL3038455 AMPK alpha2/beta1/gamma1 PROTEIN COMPLEX
CHEMBL2096907 AMP-activated protein kinase, AMPK PROTEIN COMPLEX GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000181929
Ensembl ENSG00000181929
GO Cellular Component GO:0005829 (cytosol)
GO:0016020 (membrane)
GO:0070062 (extracellular exosome)
GO:0005634 (nucleus)
GO:0031588 (nucleotide-activated protein kinase complex)
GO Molecular Function GO:0043531 (ADP binding)
GO:0004691 (cAMP-dependent protein kinase activity)
GO:0005524 (ATP binding)
GO:0016208 (AMP binding)
GO:0008603 (cAMP-dependent protein kinase regulator activity)
GO:0019901 (protein kinase binding)
GO:0004672 (protein kinase activity)
GO Biological Process GO:0006633 (fatty acid biosynthetic process)
GO:0007165 (signal transduction)
GO:0006468 (protein phosphorylation)
GO:0008286 (insulin receptor signaling pathway)
GO:0045860 (positive regulation of protein kinase activity)
GO:0010467 (gene expression)
GO:0010628 (positive regulation of gene expression)
GO:0007283 (spermatogenesis)
GO:0006110 (regulation of glycolytic process)
GO:0006996 (organelle organization)
GO:0006367 (transcription initiation from RNA polymerase II promoter)
GO:0007005 (mitochondrion organization)
GO:0007050 (cell cycle arrest)
GO:0016236 (macroautophagy)
GO:0061024 (membrane organization)
Wikipedia PRKAG1

Target Cross References - Protein

canSAR P54619
Human Protein Atlas ENSG00000181929
IntAct P54619
Guide to Pharmacology 1545 (protein kinase, AMP-activated, gamma 1 non-catalytic subunit)
PharmGKB PA33751
UniProt P54619

Target Cross References - Domain

InterPro IPR000644 (CBS_dom.)
Pfam PF00571 (CBS)

Target Cross References - Structure

PDBe 2UV7 4CFE 4REW 2UV4 2UV5 2UV6 4CFF 4RER
CREDO 2UV7 4CFE 4REW 2UV4 2UV5 2UV6 4CFF 4RER
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