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Target Report Card

Target Name and Classification

Target ID CHEMBL2373
Preferred Name C5a anaphylatoxin chemotactic receptor
Synonyms C5AR | C5AR1 | C5R1 | C5a anaphylatoxin chemotactic receptor 1 | C5a anaphylatoxin chemotactic receptor | C5a-R | C5aR | CD_antigen=CD88
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > peptide receptor (family a gpcr) > anaphylatoxin receptor family > anaphylatoxin receptor

Target Components

Component Description Relationship Accession
C5a anaphylatoxin chemotactic receptor 1 SINGLE PROTEIN P21730

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL3989871 AVACOPAN C5a anaphylatoxin chemotactic receptor antagonist 3 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000197405
Ensembl ENSG00000197405
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016323 (basolateral plasma membrane)
GO:0030667 (secretory granule membrane)
GO:0031410 (cytoplasmic vesicle)
GO:0045177 (apical part of cell)
GO Molecular Function GO:0001856 (complement component C5a binding)
GO:0004871 (signal transducer activity)
GO:0004875 (complement receptor activity)
GO:0004878 (complement component C5a receptor activity)
GO:0004930 (G-protein coupled receptor activity)
GO Biological Process GO:0000187 (activation of MAPK activity)
GO:0002430 (complement receptor mediated signaling pathway)
GO:0006915 (apoptotic process)
GO:0006935 (chemotaxis)
GO:0006954 (inflammatory response)
GO:0006955 (immune response)
GO:0006968 (cellular defense response)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007200 (phospholipase C-activating G-protein coupled receptor signaling pathway)
GO:0007202 (activation of phospholipase C activity)
GO:0007204 (positive regulation of cytosolic calcium ion concentration)
GO:0007606 (sensory perception of chemical stimulus)
GO:0010575 (positive regulation of vascular endothelial growth factor production)
GO:0010759 (positive regulation of macrophage chemotaxis)
GO:0021534 (cell proliferation in hindbrain)
GO:0030449 (regulation of complement activation)
GO:0030593 (neutrophil chemotaxis)
GO:0031100 (organ regeneration)
GO:0032494 (response to peptidoglycan)
GO:0032496 (response to lipopolysaccharide)
GO:0038178 (complement component C5a signaling pathway)
GO:0042789 (mRNA transcription from RNA polymerase II promoter)
GO:0043312 (neutrophil degranulation)
GO:0043524 (negative regulation of neuron apoptotic process)
GO:0045766 (positive regulation of angiogenesis)
GO:0050679 (positive regulation of epithelial cell proliferation)
GO:0050830 (defense response to Gram-positive bacterium)
GO:0050900 (leukocyte migration)
GO:0060326 (cell chemotaxis)
GO:0070374 (positive regulation of ERK1 and ERK2 cascade)
GO:0090023 (positive regulation of neutrophil chemotaxis)
Wikipedia C5a_receptor

Target Cross References - Protein

Human Protein Atlas ENSG00000197405
IntAct P21730
Guide to Pharmacology 32
Open Targets ENSG00000197405
PharmGKB PA25920
Pharos P21730 (Tchem)
Reactome R-HSA-375276 (Peptide ligand-binding receptors.)
R-HSA-418594 (G alpha (i) signalling events.)
R-HSA-6798695 (Neutrophil degranulation.)
R-HSA-977606 (Regulation of Complement cascade.)
UniProt P21730

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000826 (Formyl_rcpt-rel.)
IPR001274 (Anaphtx_C5AR1/C5AR2.)
IPR002234 (Anphylx_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)

Target Cross References - Structure