ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL2373
Target Type SINGLE PROTEIN
Preferred Name C5a anaphylatoxin chemotactic receptor
Synonyms C5AR | C5AR1 | C5R1 | C5a anaphylatoxin chemotactic receptor | C5a anaphylatoxin chemotactic receptor 1 | C5a-R | C5aR | CD_antigen=CD88
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > peptide receptor (family a gpcr) > anaphylatoxin receptor family > anaphylatoxin receptor

Target Components

Component Description Relationship Accession
C5a anaphylatoxin chemotactic receptor 1 SINGLE PROTEIN P21730

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000197405
Ensembl ENSG00000197405
GO Cellular Component GO:0005887 (integral to plasma membrane)
GO Molecular Function GO:0004944 (C5a anaphylatoxin receptor activity)
GO Biological Process GO:0000187 (activation of MAPK activity)
GO:0006955 (immune response)
GO:0006968 (cellular defense response)
GO:0007202 (activation of phospholipase C activity)
GO:0007204 (elevation of cytosolic calcium ion concentration)
GO:0007606 (sensory perception of chemical stimulus)
Wikipedia C5a_receptor

Target Cross References - Protein

Human Protein Atlas ENSG00000197405
IUPHAR 32 (C5a)
PharmGKB PA25920
Reactome REACT_14797 (Signaling by GPCR.)

Target Cross References - Domain

InterPro IPR000276 (7TM_GPCR_Rhodpsn.)
IPR001274 (C5A_anaphtx_rcpt.)
IPR002234 (Anphylx_rcpt.)
IPR017452 (GPCR_Rhodpsn_supfam.)
Pfam PF00001 (7tm_1)
spacer
spacer