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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2360
Target Type SINGLE PROTEIN
Preferred Name Hypoxanthine-guanine phosphoribosyltransferase
Synonyms HGPRT | HGPRTase | HPRT | HPRT1 | Hypoxanthine-guanine phosphoribosyltransferase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Hypoxanthine-guanine phosphoribosyltransferase SINGLE PROTEIN P00492

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000165704
Ensembl ENSG00000165704
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0000287 (magnesium ion binding)
GO:0004422 (hypoxanthine phosphoribosyltransferase activity)
GO:0005515 (protein binding)
GO:0016740 (transferase activity)
GO:0016757 (transferase activity, transferring glycosyl groups)
GO:0042802 (identical protein binding)
GO:0042803 (protein homodimerization activity)
GO:0046872 (metal ion binding)
GO:0052657 (guanine phosphoribosyltransferase activity)
GO Biological Process GO:0001975 (response to amphetamine)
GO:0006164 (purine nucleotide biosynthetic process)
GO:0006166 (purine ribonucleoside salvage)
GO:0006168 (adenine salvage)
GO:0006178 (guanine salvage)
GO:0007625 (grooming behavior)
GO:0007626 (locomotory behavior)
GO:0009116 (nucleoside metabolic process)
GO:0019835 (cytolysis)
GO:0021756 (striatum development)
GO:0021895 (cerebral cortex neuron differentiation)
GO:0021954 (central nervous system neuron development)
GO:0032263 (GMP salvage)
GO:0032264 (IMP salvage)
GO:0042417 (dopamine metabolic process)
GO:0043101 (purine-containing compound salvage)
GO:0043103 (hypoxanthine salvage)
GO:0045964 (positive regulation of dopamine metabolic process)
GO:0046038 (GMP catabolic process)
GO:0046040 (IMP metabolic process)
GO:0046083 (adenine metabolic process)
GO:0046100 (hypoxanthine metabolic process)
GO:0046651 (lymphocyte proliferation)
GO:0048813 (dendrite morphogenesis)
GO:0051289 (protein homotetramerization)
Wikipedia Hypoxanthine-guanine_phosphoribosyltransferase

Target Cross References - Protein

canSAR P00492
CGD Kelley-Seegmiller syndrome; Lesch-Nyhan syndrome
Human Protein Atlas ENSG00000165704
IntAct P00492
Open Targets ENSG00000165704
PharmGKB PA29427
Reactome R-HSA-74217 (Purine salvage.)
UniProt A6NHF0 B2R8M9 P00492

Target Cross References - Domain

InterPro IPR000836 (PRibTrfase_dom.)
IPR005904 (Hxn_phspho_trans.)
IPR029057 (PRTase-like.)
Pfam PF00156 (Pribosyltran)

Target Cross References - Structure

PDBe 1BZY 1D6N 1HMP 1Z7G 2VFA 3GEP 3GGC 3GGJ 4IJQ 4KN6 4RAB 4RAC 4RAD 4RAN 4RAO 4RAQ 5BRN 5BSK 5HIA
CREDO 1BZY 1D6N 1HMP 1Z7G 2VFA 3GEP 3GGC 3GGJ 4IJQ 4KN6 4RAB 4RAC 4RAD 4RAN 4RAO 4RAQ 5BRN 5BSK 5HIA
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