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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL236
Target Type SINGLE PROTEIN
Preferred Name Delta opioid receptor
Synonyms D-OR-1 | DOR-1 | Delta-type opioid receptor | OPRD | OPRD1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > peptide receptor (family a gpcr) > short peptide receptor (family a gpcr) > opioid receptor

Target Components

Component Description Relationship Accession
Delta-type opioid receptor SINGLE PROTEIN P41143

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2095151 Opioid receptors; delta & kappa SELECTIVITY GROUP
CHEMBL2095181 Opioid receptors; mu/kappa/delta PROTEIN FAMILY
CHEMBL2095149 Opioid receptors; mu & delta SELECTIVITY GROUP

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL2107731 AXOMADOL Delta opioid receptor agonist 2

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000116329
Ensembl ENSG00000116329
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0031226 (intrinsic component of plasma membrane)
GO:0031982 (vesicle)
GO:0032590 (dendrite membrane)
GO:0043005 (neuron projection)
GO:0043679 (axon terminus)
GO:0045121 (membrane raft)
GO:0045211 (postsynaptic membrane)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004985 (opioid receptor activity)
GO:0005515 (protein binding)
GO:0038046 (enkephalin receptor activity)
GO:0042923 (neuropeptide binding)
GO Biological Process GO:0000060 (protein import into nucleus, translocation)
GO:0006955 (immune response)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007187 (G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)
GO:0007193 (adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway)
GO:0007200 (phospholipase C-activating G-protein coupled receptor signaling pathway)
GO:0007218 (neuropeptide signaling pathway)
GO:0007268 (chemical synaptic transmission)
GO:0008344 (adult locomotory behavior)
GO:0010629 (negative regulation of gene expression)
GO:0019233 (sensory perception of pain)
GO:0032460 (negative regulation of protein oligomerization)
GO:0032793 (positive regulation of CREB transcription factor activity)
GO:0033138 (positive regulation of peptidyl-serine phosphorylation)
GO:0038003 (opioid receptor signaling pathway)
GO:0042755 (eating behavior)
GO:0051881 (regulation of mitochondrial membrane potential)
GO:0051924 (regulation of calcium ion transport)
GO:0051930 (regulation of sensory perception of pain)
GO:0071363 (cellular response to growth factor stimulus)
GO:0071456 (cellular response to hypoxia)
GO:0097237 (cellular response to toxic substance)

Target Cross References - Protein

Human Protein Atlas ENSG00000116329
IntAct P41143
Guide to Pharmacology 317
MICAD NBK23011 (Delta opioid receptor)
Open Targets ENSG00000116329
PharmGKB PA31942
Pharos P41143 (Tclin)
Reactome R-HSA-375276 (Peptide ligand-binding receptors.)
R-HSA-418594 (G alpha (i) signalling events.)
R-HSA-6785807 (Interleukin-4 and 13 signaling.)
UniProt B5B0B8 P41143

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000321 (Delta_opi_rcpt.)
IPR001418 (Opioid_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)

Target Cross References - Structure

PDBe 4N6H 4RWA 4RWD
CREDO 4N6H 4RWA 4RWD
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