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Target Report Card

Target Name and Classification

Target ID CHEMBL2354
Target Type SINGLE PROTEIN
Preferred Name Superoxide dismutase
Synonyms SOD1 | Superoxide dismutase 1 | Superoxide dismutase [Cu-Zn] | hSod1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Superoxide dismutase [Cu-Zn] SINGLE PROTEIN P00441

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000142168
Ensembl ENSG00000142168
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005758 (mitochondrial intermembrane space)
GO:0005759 (mitochondrial matrix)
GO:0005764 (lysosome)
GO:0005777 (peroxisome)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0030141 (secretory granule)
GO:0031012 (extracellular matrix)
GO:0031045 (dense core granule)
GO:0031410 (cytoplasmic vesicle)
GO:0032839 (dendrite cytoplasm)
GO:0043005 (neuron projection)
GO:0043025 (neuronal cell body)
GO:0043209 (myelin sheath)
GO:0043234 (protein complex)
GO:0070062 (extracellular exosome)
GO:1904115 (axon cytoplasm)
GO Molecular Function GO:0004784 (superoxide dismutase activity)
GO:0005507 (copper ion binding)
GO:0005515 (protein binding)
GO:0008270 (zinc ion binding)
GO:0016209 (antioxidant activity)
GO:0016491 (oxidoreductase activity)
GO:0019899 (enzyme binding)
GO:0030346 (protein phosphatase 2B binding)
GO:0042802 (identical protein binding)
GO:0042803 (protein homodimerization activity)
GO:0046872 (metal ion binding)
GO:0048365 (Rac GTPase binding)
GO:0051087 (chaperone binding)
GO Biological Process GO:0000187 (activation of MAPK activity)
GO:0000302 (response to reactive oxygen species)
GO:0000303 (response to superoxide)
GO:0001541 (ovarian follicle development)
GO:0001819 (positive regulation of cytokine production)
GO:0001890 (placenta development)
GO:0001895 (retina homeostasis)
GO:0001975 (response to amphetamine)
GO:0002262 (myeloid cell homeostasis)
GO:0002576 (platelet degranulation)
GO:0006749 (glutathione metabolic process)
GO:0006801 (superoxide metabolic process)
GO:0006879 (cellular iron ion homeostasis)
GO:0006979 (response to oxidative stress)
GO:0007283 (spermatogenesis)
GO:0007566 (embryo implantation)
GO:0007568 (aging)
GO:0007569 (cell aging)
GO:0007605 (sensory perception of sound)
GO:0007626 (locomotory behavior)
GO:0008089 (anterograde axonal transport)
GO:0008090 (retrograde axonal transport)
GO:0008217 (regulation of blood pressure)
GO:0009408 (response to heat)
GO:0010033 (response to organic substance)
GO:0019226 (transmission of nerve impulse)
GO:0019430 (removal of superoxide radicals)
GO:0031667 (response to nutrient levels)
GO:0032287 (peripheral nervous system myelin maintenance)
GO:0032930 (positive regulation of superoxide anion generation)
GO:0033081 (regulation of T cell differentiation in thymus)
GO:0034465 (response to carbon monoxide)
GO:0034599 (cellular response to oxidative stress)
GO:0035865 (cellular response to potassium ion)
GO:0040014 (regulation of multicellular organism growth)
GO:0042493 (response to drug)
GO:0042542 (response to hydrogen peroxide)
GO:0042554 (superoxide anion generation)
GO:0043065 (positive regulation of apoptotic process)
GO:0043066 (negative regulation of apoptotic process)
GO:0043085 (positive regulation of catalytic activity)
GO:0043087 (regulation of GTPase activity)
GO:0043524 (negative regulation of neuron apoptotic process)
GO:0045471 (response to ethanol)
GO:0045541 (negative regulation of cholesterol biosynthetic process)
GO:0045859 (regulation of protein kinase activity)
GO:0046620 (regulation of organ growth)
GO:0046677 (response to antibiotic)
GO:0046688 (response to copper ion)
GO:0046716 (muscle cell cellular homeostasis)
GO:0048538 (thymus development)
GO:0048678 (response to axon injury)
GO:0050665 (hydrogen peroxide biosynthetic process)
GO:0051881 (regulation of mitochondrial membrane potential)
GO:0055114 (oxidation-reduction process)
GO:0060047 (heart contraction)
GO:0060052 (neurofilament cytoskeleton organization)
GO:0060087 (relaxation of vascular smooth muscle)
GO:0060088 (auditory receptor cell stereocilium organization)
GO:0071276 (cellular response to cadmium ion)
GO:0071318 (cellular response to ATP)
GO:0072593 (reactive oxygen species metabolic process)
GO:0097332 (response to antipsychotic drug)
GO:1902177 (positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)
Wikipedia SOD1

Target Cross References - Protein

canSAR P00441
CGD Amyotrophic lateral sclerosis; Keratoconus
Human Protein Atlas ENSG00000142168
IntAct P00441
Open Targets ENSG00000142168
PharmGKB PA334
Reactome R-HSA-114608 (Platelet degranulation.)
R-HSA-3299685 (Detoxification of Reactive Oxygen Species.)
TIMBAL SOD1
UniProt A6NHJ0 D3DSE4 P00441 Q16669 Q16711 Q16838 Q16839 Q16840 Q6NR85

Target Cross References - Domain

InterPro IPR001424 (SOD_Cu_Zn_dom.)
IPR018152 (SOD_Cu/Zn_BS.)
Pfam PF00080 (Sod_Cu)

Target Cross References - Structure

PDBe 1AZV 1FUN 1HL4 1HL5 1MFM 1N18 1N19 1OEZ 1OZT 1OZU 1P1V 1PTZ 1PU0 1SOS 1SPD 1UXL 1UXM 2C9S 2C9U 2C9V 2GBT 2GBU 2GBV 2NNX More...
CREDO 1AZV 1FUN 1HL4 1HL5 1MFM 1N18 1N19 1OEZ 1OZT 1OZU 1P1V 1PTZ 1PU0 1SOS 1SPD 1UXL 1UXM 2C9S 2C9U 2C9V 2GBT 2GBU 2GBV 2NNX More...
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