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Target Report Card

Target Name and Classification

Target ID CHEMBL2354
Target Type SINGLE PROTEIN
Preferred Name Superoxide dismutase
Synonyms SOD1 | Superoxide dismutase 1 | Superoxide dismutase [Cu-Zn] | hSod1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Superoxide dismutase [Cu-Zn] SINGLE PROTEIN P00441

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000142168
Ensembl ENSG00000142168
GO Cellular Component GO:0005615 (extracellular space)
GO:0005634 (nucleus)
GO:0005759 (mitochondrial matrix)
GO:0005777 (peroxisome)
GO:0005829 (cytosol)
GO:0031012 (extracellular matrix)
GO:0031410 (cytoplasmic vesicle)
GO:0032839 (dendrite cytoplasm)
GO:0043025 (neuronal cell body)
GO:0043234 (protein complex)
GO Molecular Function GO:0004784 (superoxide dismutase activity)
GO:0005507 (copper ion binding)
GO:0008270 (zinc ion binding)
GO:0030346 (protein phosphatase 2B binding)
GO:0042803 (protein homodimerization activity)
GO:0051087 (chaperone binding)
GO Biological Process GO:0000187 (activation of MAPK activity)
GO:0001541 (ovarian follicle development)
GO:0001819 (positive regulation of cytokine production)
GO:0001890 (placenta development)
GO:0001895 (retina homeostasis)
GO:0002262 (myeloid cell homeostasis)
GO:0002576 (platelet degranulation)
GO:0006302 (double-strand break repair)
GO:0006309 (DNA fragmentation involved in apoptotic nuclear change)
GO:0006749 (glutathione metabolic process)
GO:0006879 (cellular iron ion homeostasis)
GO:0007283 (spermatogenesis)
GO:0007566 (embryo implantation)
GO:0007569 (cell aging)
GO:0007605 (sensory perception of sound)
GO:0007626 (locomotory behavior)
GO:0008217 (regulation of blood pressure)
GO:0009408 (response to heat)
GO:0019430 (removal of superoxide radicals)
GO:0030168 (platelet activation)
GO:0032287 (peripheral nervous system myelin maintenance)
GO:0033081 (regulation of T cell differentiation in thymus)
GO:0040014 (regulation of multicellular organism growth)
GO:0042493 (response to drug)
GO:0042542 (response to hydrogen peroxide)
GO:0043524 (negative regulation of neuron apoptosis)
GO:0045471 (response to ethanol)
GO:0045541 (negative regulation of cholesterol biosynthetic process)
GO:0046620 (regulation of organ growth)
GO:0046716 (muscle cell homeostasis)
GO:0048538 (thymus development)
GO:0048678 (response to axon injury)
GO:0050665 (hydrogen peroxide biosynthetic process)
GO:0051881 (regulation of mitochondrial membrane potential)
GO:0060047 (heart contraction)
GO:0060052 (neurofilament cytoskeleton organization)
GO:0060087 (relaxation of vascular smooth muscle)
GO:0060088 (auditory receptor cell stereocilium organization)
Wikipedia SOD1

Target Cross References - Protein

canSAR P00441
CGD Amyotrophic lateral sclerosis; Keratoconus
Human Protein Atlas ENSG00000142168
IntAct P00441
PharmGKB PA334
Reactome REACT_604 (Hemostasis.)
TIMBAL SOD1
UniProt A6NHJ0 D3DSE4 P00441 Q16669 Q16711 Q16838 Q16839 Q16840 Q6NR85

Target Cross References - Domain

InterPro IPR001424 (SOD_Cu_Zn.)
IPR018152 (SOD_Cu/Zn_BS.)
Pfam PF00080 (Sod_Cu)

Target Cross References - Structure

PDBe 1AZV 1FUN 1HL4 1HL5 1MFM 1N18 1N19 1OEZ 1OZT 1OZU 1P1V 1PTZ 1PU0 1SOS 1SPD 1UXL 1UXM 2C9S 2C9U 2C9V 2GBT 2GBU 2GBV 2NNX More...
CREDO 1AZV 1FUN 1HL4 1HL5 1MFM 1N18 1N19 1OEZ 1OZT 1OZU 1P1V 1PTZ 1PU0 1SOS 1SPD 1UXL 1UXM 2C9S 2C9U 2C9V 2GBT 2GBU 2GBV 2NNX More...
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