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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL235
Target Type SINGLE PROTEIN
Preferred Name Peroxisome proliferator-activated receptor gamma
Synonyms NR1C3 | Nuclear receptor subfamily 1 group C member 3 | PPAR-gamma | PPARG | Peroxisome proliferator-activated receptor gamma
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transcription factor > nuclear receptor > nuclear hormone receptor subfamily 1 > nuclear hormone receptor subfamily 1 group c > nuclear hormone receptor subfamily 1 group c member 3

Target Components

Component Description Relationship Accession
Peroxisome proliferator-activated receptor gamma SINGLE PROTEIN P37231

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2095161 Peroxisome proliferator-activated receptor gamma/Nuclear receptor coactivator 3 PROTEIN-PROTEIN INTERACTION
CHEMBL2095162 Peroxisome proliferator-activated receptor gamma/Nuclear receptor coactivator 1 PROTEIN-PROTEIN INTERACTION
CHEMBL2111394 RXR alpha/PPAR gamma PROTEIN COMPLEX
CHEMBL2111325 PPAR alpha/gamma SELECTIVITY GROUP
CHEMBL2095163 Peroxisome proliferator-activated receptor gamma/Nuclear receptor coactivator 2 PROTEIN-PROTEIN INTERACTION
CHEMBL2096976 Peroxisome proliferator-activated receptor gamma/Nuclear receptor corepressor 2 PROTEIN-PROTEIN INTERACTION
CHEMBL2111371 PPAR delta/gamma SELECTIVITY GROUP

Approved Drugs

ChEMBL ID Name Mechanism of Action References
CHEMBL1200760 BALSALAZIDE DISODIUM Peroxisome proliferator-activated receptor gamma agonist PubMed PubMed PubMed
CHEMBL704 MESALAMINE Peroxisome proliferator-activated receptor gamma agonist PubMed PubMed PubMed
CHEMBL1201013 OLSALAZINE SODIUM Peroxisome proliferator-activated receptor gamma agonist DailyMed PubMed PubMed PubMed
CHEMBL1715 PIOGLITAZONE HYDROCHLORIDE Peroxisome proliferator-activated receptor gamma agonist DailyMed
CHEMBL843 ROSIGLITAZONE MALEATE Peroxisome proliferator-activated receptor gamma agonist DailyMed
CHEMBL408 TROGLITAZONE Peroxisome proliferator-activated receptor gamma agonist PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000132170
Ensembl ENSG00000132170
GO Cellular Component GO:0005654 (nucleoplasm)
GO:0005829 (cytosol)
GO Molecular Function GO:0003700 (sequence-specific DNA binding transcription factor activity)
GO:0003707 (steroid hormone receptor activity)
GO:0004955 (prostaglandin receptor activity)
GO:0008144 (drug binding)
GO:0008270 (zinc ion binding)
GO:0010843 (promoter binding)
GO:0016563 (transcription activator activity)
GO:0016564 (transcription repressor activity)
GO:0016566 (specific transcriptional repressor activity)
GO:0019899 (enzyme binding)
GO:0033613 (activating transcription factor binding)
GO:0043565 (sequence-specific DNA binding)
GO:0046965 (retinoid X receptor binding)
GO:0050544 (arachidonic acid binding)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0001890 (placenta development)
GO:0006917 (induction of apoptosis)
GO:0006919 (activation of caspase activity)
GO:0008217 (regulation of blood pressure)
GO:0010745 (negative regulation of macrophage derived foam cell differentiation)
GO:0010871 (negative regulation of receptor biosynthetic process)
GO:0010887 (negative regulation of cholesterol storage)
GO:0010891 (negative regulation of sequestering of triglyceride)
GO:0015909 (long-chain fatty acid transport)
GO:0030224 (monocyte differentiation)
GO:0030855 (epithelial cell differentiation)
GO:0032869 (cellular response to insulin stimulus)
GO:0033993 (response to lipid)
GO:0034339 (regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor)
GO:0042593 (glucose homeostasis)
GO:0042953 (lipoprotein transport)
GO:0045087 (innate immune response)
GO:0045165 (cell fate commitment)
GO:0045600 (positive regulation of fat cell differentiation)
GO:0045713 (low-density lipoprotein particle receptor biosynthetic process)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0048469 (cell maturation)
GO:0050872 (white fat cell differentiation)
GO:0051091 (positive regulation of sequence-specific DNA binding transcription factor activity)
GO:0055088 (lipid homeostasis)
GO:0055098 (response to low-density lipoprotein particle stimulus)
GO:0060336 (negative regulation of interferon-gamma-mediated signaling pathway)
Wikipedia Peroxisome_proliferator-activated_receptor_gamma

Target Cross References - Protein

canSAR P37231
CGD Lipodystrophy, familial, partial, type 3; Insulin resistance, severe, digenic
Human Protein Atlas ENSG00000132170
IntAct P37231
Guide to Pharmacology 595 (Peroxisome proliferator-activated receptor-γ)
PharmGKB PA281
Reactome REACT_15380 (Diabetes pathways.)
REACT_71 (Gene Expression.)
TIMBAL PPAR-gamma
UniProt A8K3G6 B5BUA1 O00684 O00710 O14515 P37231 Q15178 Q15179 Q15180 Q15832 Q86U60 Q96J12

Target Cross References - Domain

InterPro IPR000536 (Nucl_hrmn_rcpt_lig-bd_core.)
IPR001628 (Znf_hrmn_rcpt.)
IPR001723 (Str_hrmn_rcpt.)
IPR003074 (1Cnucl_rcpt.)
IPR003077 (1Cnucl_rcpt_G.)
IPR008946 (Nucl_hormone_rcpt_ligand-bd.)
IPR013088 (Znf_NHR/GATA.)
IPR022590 (PPARgamma_N.)
Pfam PF00104 (Hormone_recep)
PF00105 (zf-C4)
PF12577 (PPARgamma_N)

Target Cross References - Structure

PDBe 1FM6 1FM9 1I7I 1K74 1KNU 1NYX 1PRG 1RDT 1WM0 1ZEO 1ZGY 2ATH 2F4B 2FVJ 2G0G 2G0H 2GTK 2HFP 2HWQ 2HWR 2I4J 2I4P 2I4Z 2OM9 More...
CREDO 1FM6 1FM9 1I7I 1K74 1KNU 1NYX 1PRG 1RDT 1WM0 1ZEO 1ZGY 2ATH 2F4B 2FVJ 2G0G 2G0H 2GTK 2HFP 2HWQ 2HWR 2I4J 2I4P 2I4Z 2OM9 More...
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