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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2349
Target Type SINGLE PROTEIN
Preferred Name Phosphorylase kinase gamma subunit 2
Synonyms PHK-gamma-LT | PHK-gamma-T | PHKG2 | PSK-C3 | Phosphorylase b kinase gamma catalytic chain, liver/testis isoform | Phosphorylase kinase subunit gamma-2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > camk protein kinase group > camk protein kinase phk family

Target Components

Component Description Relationship Accession
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform SINGLE PROTEIN P15735

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111324 Phosphorylase kinase PROTEIN COMPLEX GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000156873
Ensembl ENSG00000156873
GO Cellular Component GO:0005575 (cellular_component)
GO:0005829 (cytosol)
GO:0005964 (phosphorylase kinase complex)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004689 (phosphorylase kinase activity)
GO:0005516 (calmodulin binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0019899 (enzyme binding)
GO:0050321 (tau-protein kinase activity)
GO Biological Process GO:0005975 (carbohydrate metabolic process)
GO:0005977 (glycogen metabolic process)
GO:0005978 (glycogen biosynthetic process)
GO:0005980 (glycogen catabolic process)
GO:0006091 (generation of precursor metabolites and energy)
GO:0006468 (protein phosphorylation)
GO:0016310 (phosphorylation)
GO:0045819 (positive regulation of glycogen catabolic process)
Wikipedia PHKG2

Target Cross References - Protein

canSAR P15735
CGD Glycogen storage disease IXc
Human Protein Atlas ENSG00000156873
IntAct P15735
Guide to Pharmacology 2147
Open Targets ENSG00000156873
PharmGKB PA33272
Pharos P15735 (Tchem)
Reactome R-HSA-70221 (Glycogen breakdown (glycogenolysis).)
UniProt A8K0C7 B4DEB7 E9PEU3 P11800 P15735

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR002291 (Phosph_kin_gamma.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020636 (Ca/CaM-dep_Ca-dep_prot_Kinase.)
Pfam PF00069 (Pkinase)

Target Cross References - Structure

PDBe 2Y7J
CREDO 2Y7J
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