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Target Report Card

Target Name and Classification

Target ID CHEMBL2334
Target Type SINGLE PROTEIN
Preferred Name Caspase-3
Synonyms Apopain | CASP-3 | CASP3 | CPP-32 | CPP32 | Caspase-3 subunit p12 | Caspase-3 subunit p17 | Caspase-3 | Cysteine protease CPP32 | Protein Yama | SCA-1 | SREBP cleavage activity 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > cysteine protease > cysteine protease cd clan > cysteine protease c14 family

Target Components

Component Description Relationship Accession
Caspase-3 SINGLE PROTEIN P42574

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3831289 Caspase PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000164305
Ensembl ENSG00000164305
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0031264 (death-inducing signaling complex)
GO:0045121 (membrane raft)
GO Molecular Function GO:0002020 (protease binding)
GO:0004190 (aspartic-type endopeptidase activity)
GO:0004197 (cysteine-type endopeptidase activity)
GO:0004861 (cyclin-dependent protein serine/threonine kinase inhibitor activity)
GO:0005123 (death receptor binding)
GO:0005515 (protein binding)
GO:0008233 (peptidase activity)
GO:0008234 (cysteine-type peptidase activity)
GO:0008656 (cysteine-type endopeptidase activator activity involved in apoptotic process)
GO:0016005 (phospholipase A2 activator activity)
GO:0016787 (hydrolase activity)
GO:0032403 (protein complex binding)
GO:0097153 (cysteine-type endopeptidase activity involved in apoptotic process)
GO:0097200 (cysteine-type endopeptidase activity involved in execution phase of apoptosis)
GO Biological Process GO:0001666 (response to hypoxia)
GO:0001782 (B cell homeostasis)
GO:0006309 (apoptotic DNA fragmentation)
GO:0006508 (proteolysis)
GO:0006915 (apoptotic process)
GO:0006919 (activation of cysteine-type endopeptidase activity involved in apoptotic process)
GO:0006921 (cellular component disassembly involved in execution phase of apoptosis)
GO:0006974 (cellular response to DNA damage stimulus)
GO:0007507 (heart development)
GO:0007605 (sensory perception of sound)
GO:0007611 (learning or memory)
GO:0008635 (activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)
GO:0009411 (response to UV)
GO:0009611 (response to wounding)
GO:0009749 (response to glucose)
GO:0010033 (response to organic substance)
GO:0010038 (response to metal ion)
GO:0010165 (response to X-ray)
GO:0014070 (response to organic cyclic compound)
GO:0016241 (regulation of macroautophagy)
GO:0016485 (protein processing)
GO:0021766 (hippocampus development)
GO:0030182 (neuron differentiation)
GO:0030216 (keratinocyte differentiation)
GO:0030218 (erythrocyte differentiation)
GO:0030220 (platelet formation)
GO:0030889 (negative regulation of B cell proliferation)
GO:0032025 (response to cobalt ion)
GO:0032355 (response to estradiol)
GO:0032496 (response to lipopolysaccharide)
GO:0034349 (glial cell apoptotic process)
GO:0034612 (response to tumor necrosis factor)
GO:0035094 (response to nicotine)
GO:0035329 (hippo signaling)
GO:0035556 (intracellular signal transduction)
GO:0042060 (wound healing)
GO:0042493 (response to drug)
GO:0042542 (response to hydrogen peroxide)
GO:0043029 (T cell homeostasis)
GO:0043065 (positive regulation of apoptotic process)
GO:0043066 (negative regulation of apoptotic process)
GO:0043085 (positive regulation of catalytic activity)
GO:0043200 (response to amino acid)
GO:0043525 (positive regulation of neuron apoptotic process)
GO:0045165 (cell fate commitment)
GO:0045736 (negative regulation of cyclin-dependent protein serine/threonine kinase activity)
GO:0045786 (negative regulation of cell cycle)
GO:0046007 (negative regulation of activated T cell proliferation)
GO:0046677 (response to antibiotic)
GO:0048011 (neurotrophin TRK receptor signaling pathway)
GO:0051384 (response to glucocorticoid)
GO:0051402 (neuron apoptotic process)
GO:0071310 (cellular response to organic substance)
GO:0071407 (cellular response to organic cyclic compound)
GO:0097190 (apoptotic signaling pathway)
GO:0097192 (extrinsic apoptotic signaling pathway in absence of ligand)
GO:0097194 (execution phase of apoptosis)
Wikipedia Caspase_3

Target Cross References - Protein

canSAR P42574
Human Protein Atlas ENSG00000164305
IntAct P42574
Guide to Pharmacology 1619
Open Targets ENSG00000164305
PharmGKB PA26087
Reactome R-HSA-111459 (Activation of caspases through apoptosome-mediated cleavage.)
R-HSA-111463 (SMAC binds to IAPs.)
R-HSA-111464 (SMAC-mediated dissociation of IAP:caspase complexes.)
R-HSA-111465 (Apoptotic cleavage of cellular proteins.)
R-HSA-1474228 (Degradation of the extracellular matrix.)
R-HSA-2028269 (Signaling by Hippo.)
R-HSA-205025 (NADE modulates death signalling.)
R-HSA-211227 (Activation of DNA fragmentation factor.)
R-HSA-211736 (Stimulation of the cell death response by PAK-2p34.)
R-HSA-264870 (Caspase-mediated cleavage of cytoskeletal proteins.)
R-HSA-351906 (Apoptotic cleavage of cell adhesion proteins.)
R-HSA-418889 (Ligand-independent caspase activation via DCC.)
R-HSA-449147 (Signaling by Interleukins.)
UniProt A8K5M2 D3DP53 P42574 Q96AN1 Q96KP2

Target Cross References - Domain

InterPro IPR001309 (Pept_C14_p20.)
IPR002138 (Pept_C14_p10.)
IPR015470 (Caspase_3.)
IPR015917 (Pept_C14A.)
IPR016129 (Caspase_his_AS.)
IPR029030 (Caspase-like_dom.)
IPR033139 (Caspase_cys_AS.)

Target Cross References - Structure

PDBe 1CP3 1GFW 1I3O 1NME 1NMQ 1NMS 1PAU 1QX3 1RE1 1RHJ 1RHK 1RHM 1RHQ 1RHR 1RHU 2C1E 2C2K 2C2M 2C2O 2CDR 2CJX 2CJY 2CNK 2CNL More...
CREDO 1CP3 1GFW 1I3O 1NME 1NMQ 1NMS 1PAU 1QX3 1RE1 1RHJ 1RHK 1RHM 1RHQ 1RHR 1RHU 2C1E 2C2K 2C2M 2C2O 2CDR 2CJX 2CJY 2CNK 2CNL More...
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