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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL233
Target Type SINGLE PROTEIN
Preferred Name Mu opioid receptor
Synonyms M-OR-1 | MOP | MOR-1 | MOR1 | Mu opiate receptor | Mu opioid receptor | Mu-type opioid receptor | OPRM1 | hMOP
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > peptide receptor (family a gpcr) > short peptide receptor (family a gpcr) > opioid receptor

Target Components

Component Description Relationship Accession
Mu-type opioid receptor SINGLE PROTEIN P35372

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2095156 Opioid receptors; mu & kappa SELECTIVITY GROUP
CHEMBL2095181 Opioid receptors; mu/kappa/delta PROTEIN FAMILY
CHEMBL3301384 CCR5/mu opioid receptor complex PROTEIN COMPLEX
CHEMBL2095149 Opioid receptors; mu & delta SELECTIVITY GROUP

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL596 FENTANYL Mu opioid receptor agonist 4 DailyMed
CHEMBL656 OXYCODONE Mu opioid receptor agonist 4 DailyMed
CHEMBL688 FENTANYL CITRATE Mu opioid receptor agonist 4 DailyMed
CHEMBL299400 BUTORPHANOL TARTRATE Mu opioid receptor partial agonist 4 DailyMed
CHEMBL270190 ALVIMOPAN Mu opioid receptor antagonist 4 DailyMed FDA
CHEMBL511142 BUPRENORPHINE Mu opioid receptor agonist 4 DailyMed
CHEMBL1685 DEZOCINE Mu opioid receptor partial agonist 4 ISBN PubMed
CHEMBL1701 MEPERIDINE HYDROCHLORIDE Mu opioid receptor agonist 4 PubMed
CHEMBL1707 LOPERAMIDE HYDROCHLORIDE Mu opioid receptor agonist 4 DailyMed PubMed PubMed
CHEMBL1200531 ALFENTANIL HYDROCHLORIDE Mu opioid receptor agonist 4 DailyMed PubMed
CHEMBL1200543 ANILERIDINE PHOSPHATE Mu opioid receptor agonist 4 PubMed
CHEMBL1200599 DIFENOXIN HYDROCHLORIDE Mu opioid receptor agonist 4 PubMed
CHEMBL1200611 OXYCODONE TEREPHTHALATE Mu opioid receptor agonist 4 DailyMed
CHEMBL1200665 DIPHENOXYLATE HYDROCHLORIDE Mu opioid receptor agonist 4 PubMed
CHEMBL1200817 LEVOMETHADYL ACETATE HYDROCHLORIDE Mu opioid receptor agonist 4 PubMed
CHEMBL1200825 METHADONE HYDROCHLORIDE Mu opioid receptor agonist 4 DailyMed
CHEMBL1200890 OXYCODONE HYDROCHLORIDE Mu opioid receptor agonist 4 DailyMed
CHEMBL1201047 ANILERIDINE HYDROCHLORIDE Mu opioid receptor agonist 4 PubMed
CHEMBL1201120 REMIFENTANIL HYDROCHLORIDE Mu opioid receptor agonist 4 DailyMed
CHEMBL1201159 FENTANYL HYDROCHLORIDE Mu opioid receptor agonist 4 DailyMed
CHEMBL1201163 SUFENTANIL CITRATE Mu opioid receptor agonist 4 DailyMed PubMed
CHEMBL1201770 METHYLNALTREXONE BROMIDE Mu opioid receptor antagonist 4 DailyMed
CHEMBL1201777 TAPENTADOL HYDROCHLORIDE Mu opioid receptor agonist 4 DailyMed
CHEMBL1237055 HYDROMORPHONE HYDROCHLORIDE Mu opioid receptor agonist 4 DailyMed
CHEMBL1237065 TRAMADOL HYDROCHLORIDE Mu opioid receptor agonist 4 DailyMed FDA
CHEMBL1237085 PROPOXYPHENE NAPSYLATE Mu opioid receptor agonist 4 DailyMed PubMed
CHEMBL1237104 PROPOXYPHENE HYDROCHLORIDE Mu opioid receptor agonist 4 DailyMed PubMed
CHEMBL2062261 LEVORPHANOL TARTRATE Mu opioid receptor agonist 4 DailyMed DailyMed DailyMed
CHEMBL2062266 DIHYDROCODEINE BITARTRATE Mu opioid receptor agonist 4 PubMed
CHEMBL2062276 LEVALLORPHAN TARTRATE Mu opioid receptor antagonist 4 PubMed
CHEMBL2103744 MORPHINE SULFATE HYDRATE Mu opioid receptor agonist 4 DailyMed FDA
CHEMBL2105755 NALDEMEDINE Mu opioid receptor antagonist 4 FDA Other PubMed
CHEMBL2159122 ELUXADOLINE Mu opioid receptor agonist 4 FDA
CHEMBL2219416 NALOXEGOL OXALATE Mu opioid receptor antagonist 4 FDA
CHEMBL2368861 Buprenorphine Hydrochloride Mu opioid receptor agonist 4 DailyMed
CHEMBL3039508 NALDEMEDINE TOSYLATE Mu opioid receptor antagonist 4 FDA Other Other PubMed
CHEMBL2443262 OLICERIDINE Mu opioid receptor agonist 3 PubMed
CHEMBL3039511 BEVENOPRAN Mu opioid receptor antagonist 3 Other
CHEMBL426084 SAMIDORPHAN Mu opioid receptor antagonist 2 PubMed
CHEMBL2103829 FAXELADOL Mu opioid receptor agonist 2 PubMed
CHEMBL2105081 FRAKEFAMIDE Mu opioid receptor agonist 2 PubMed
CHEMBL2107731 AXOMADOL Mu opioid receptor agonist 2
CHEMBL2364619 METHYLSAMIDORPHAN Mu opioid receptor antagonist 2 Other PubMed
CHEMBL3137313 AXELOPRAN Mu opioid receptor antagonist 2 Other Other PubMed
CHEMBL3545408 Naltalimide Mu opioid receptor partial agonist 2 PubMed
More...

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000112038
Ensembl ENSG00000112038
GO Cellular Component GO:0005623 (cell)
GO:0005737 (cytoplasm)
GO:0005783 (endoplasmic reticulum)
GO:0005794 (Golgi apparatus)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0005925 (focal adhesion)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030425 (dendrite)
GO:0032590 (dendrite membrane)
GO:0032839 (dendrite cytoplasm)
GO:0042383 (sarcolemma)
GO:0043005 (neuron projection)
GO:0043204 (perikaryon)
GO:0045121 (membrane raft)
GO:0098794 (postsynapse)
GO Molecular Function GO:0001965 (G-protein alpha-subunit binding)
GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004979 (beta-endorphin receptor activity)
GO:0004985 (opioid receptor activity)
GO:0005245 (voltage-gated calcium channel activity)
GO:0005515 (protein binding)
GO:0008022 (protein C-terminus binding)
GO:0019904 (protein domain specific binding)
GO:0031005 (filamin binding)
GO:0031681 (G-protein beta-subunit binding)
GO:0038047 (morphine receptor activity)
GO:0042923 (neuropeptide binding)
GO Biological Process GO:0002438 (acute inflammatory response to antigenic stimulus)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007187 (G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)
GO:0007191 (adenylate cyclase-activating dopamine receptor signaling pathway)
GO:0007193 (adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway)
GO:0007194 (negative regulation of adenylate cyclase activity)
GO:0007200 (phospholipase C-activating G-protein coupled receptor signaling pathway)
GO:0007204 (positive regulation of cytosolic calcium ion concentration)
GO:0007218 (neuropeptide signaling pathway)
GO:0007268 (chemical synaptic transmission)
GO:0007600 (sensory perception)
GO:0007626 (locomotory behavior)
GO:0008285 (negative regulation of cell proliferation)
GO:0009314 (response to radiation)
GO:0019233 (sensory perception of pain)
GO:0030818 (negative regulation of cAMP biosynthetic process)
GO:0031635 (adenylate cyclase-inhibiting opioid receptor signaling pathway)
GO:0032094 (response to food)
GO:0032100 (positive regulation of appetite)
GO:0032496 (response to lipopolysaccharide)
GO:0033554 (cellular response to stress)
GO:0038003 (opioid receptor signaling pathway)
GO:0042060 (wound healing)
GO:0042220 (response to cocaine)
GO:0042755 (eating behavior)
GO:0043278 (response to morphine)
GO:0043950 (positive regulation of cAMP-mediated signaling)
GO:0043951 (negative regulation of cAMP-mediated signaling)
GO:0044849 (estrous cycle)
GO:0045019 (negative regulation of nitric oxide biosynthetic process)
GO:0045429 (positive regulation of nitric oxide biosynthetic process)
GO:0045471 (response to ethanol)
GO:0048149 (behavioral response to ethanol)
GO:0050769 (positive regulation of neurogenesis)
GO:0051481 (negative regulation of cytosolic calcium ion concentration)
GO:0051930 (regulation of sensory perception of pain)
GO:0060079 (excitatory postsynaptic potential)
GO:0061358 (negative regulation of Wnt protein secretion)
GO:0070374 (positive regulation of ERK1 and ERK2 cascade)
GO:0070588 (calcium ion transmembrane transport)
GO:0070848 (response to growth factor)
GO:0071315 (cellular response to morphine)
GO:2000310 (regulation of N-methyl-D-aspartate selective glutamate receptor activity)
Wikipedia Mu_Opioid_receptor

Target Cross References - Protein

canSAR P35372
Human Protein Atlas ENSG00000112038
IntAct P35372
Guide to Pharmacology 319
MICAD NBK23273 (Mu opioid receptor)
Open Targets ENSG00000112038
PharmGKB PA31945
Pharos P35372 (Tclin)
Reactome R-HSA-111885 (Opioid Signalling.)
R-HSA-202040 (G-protein activation.)
R-HSA-375276 (Peptide ligand-binding receptors.)
R-HSA-418594 (G alpha (i) signalling events.)
R-HSA-6785807 (Interleukin-4 and 13 signaling.)
UniProt B0FXJ1 B2R9S7 B8Q1L7 B8Q1L8 B8Q1L9 E7EWZ3 G8XRH6 G8XRH8 P35372 Q12930 Q4VWM1 Q4VWM2 Q4VWM3 Q4VWM4 Q4VWM6 Q4VWX6 Q5TDA1 Q6UPP1 Q6UQ80 Q7Z2D8 Q86V80 Q8IWW3 Q8IWW4 Q9UCZ4 Q9UN57

Target Cross References - Domain

InterPro IPR000105 (Mu_opioid_rcpt.)
IPR000276 (GPCR_Rhodpsn.)
IPR001418 (Opioid_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)
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