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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL233
Target Type SINGLE PROTEIN
Preferred Name Mu opioid receptor
Synonyms M-OR-1 | MOP | MOR-1 | MOR1 | Mu opiate receptor | Mu opioid receptor | Mu-type opioid receptor | OPRM1 | hMOP
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > peptide receptor (family a gpcr) > short peptide receptor (family a gpcr) > opioid receptor

Target Components

Component Description Relationship Accession
Mu-type opioid receptor SINGLE PROTEIN P35372

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2095181 Opioid receptors; mu/kappa/delta PROTEIN FAMILY
CHEMBL2095149 Opioid receptors; mu & delta SELECTIVITY GROUP
CHEMBL3301384 CCR5/mu opioid receptor complex PROTEIN COMPLEX
CHEMBL2095156 Opioid receptors; mu & kappa SELECTIVITY GROUP

Approved Drugs

ChEMBL ID Name Mechanism of Action References
CHEMBL1200531 ALFENTANIL HYDROCHLORIDE Mu opioid receptor agonist DailyMed PubMed
CHEMBL270190 ALVIMOPAN Mu opioid receptor antagonist DailyMed
CHEMBL1201047 ANILERIDINE HYDROCHLORIDE Mu opioid receptor agonist PubMed
CHEMBL1200543 ANILERIDINE PHOSPHATE Mu opioid receptor agonist PubMed
CHEMBL511142 BUPRENORPHINE Mu opioid receptor agonist DailyMed
CHEMBL299400 BUTORPHANOL TARTRATE Mu opioid receptor partial agonist DailyMed
CHEMBL2368861 Buprenorphine Hydrochloride Mu opioid receptor agonist DailyMed
CHEMBL1685 DEZOCINE Mu opioid receptor partial agonist ISBN PubMed
CHEMBL1200599 DIFENOXIN HYDROCHLORIDE Mu opioid receptor agonist PubMed
CHEMBL2062266 DIHYDROCODEINE BITARTRATE Mu opioid receptor agonist PubMed
CHEMBL1200665 DIPHENOXYLATE HYDROCHLORIDE Mu opioid receptor agonist PubMed
CHEMBL596 FENTANYL Mu opioid receptor agonist DailyMed
CHEMBL688 FENTANYL CITRATE Mu opioid receptor agonist DailyMed
CHEMBL1201159 FENTANYL HYDROCHLORIDE Mu opioid receptor agonist DailyMed
CHEMBL1237055 HYDROMORPHONE HYDROCHLORIDE Mu opioid receptor agonist DailyMed
CHEMBL2062276 LEVALLORPHAN TARTRATE Mu opioid receptor antagonist PubMed
CHEMBL1200817 LEVOMETHADYL ACETATE HYDROCHLORIDE Mu opioid receptor agonist PubMed
CHEMBL2062261 LEVORPHANOL TARTRATE Mu opioid receptor agonist DailyMed
CHEMBL1707 LOPERAMIDE HYDROCHLORIDE Mu opioid receptor agonist DailyMed PubMed PubMed
CHEMBL1701 MEPERIDINE HYDROCHLORIDE Mu opioid receptor agonist PubMed
CHEMBL1200825 METHADONE HYDROCHLORIDE Mu opioid receptor agonist DailyMed
CHEMBL1201770 METHYLNALTREXONE BROMIDE Mu opioid receptor antagonist DailyMed
CHEMBL2103744 MORPHINE SULFATE HYDRATE Mu opioid receptor agonist DailyMed
CHEMBL2219416 NALOXEGOL OXALATE Mu opioid receptor antagonist FDA
CHEMBL1200890 OXYCODONE HYDROCHLORIDE Mu opioid receptor agonist DailyMed
CHEMBL1200611 OXYCODONE TEREPHTHALATE Mu opioid receptor agonist DailyMed
CHEMBL1237104 PROPOXYPHENE HYDROCHLORIDE Mu opioid receptor agonist DailyMed PubMed
CHEMBL1237085 PROPOXYPHENE NAPSYLATE Mu opioid receptor agonist DailyMed PubMed
CHEMBL1201120 REMIFENTANIL HYDROCHLORIDE Mu opioid receptor agonist DailyMed
CHEMBL1201163 SUFENTANIL CITRATE Mu opioid receptor agonist DailyMed PubMed
CHEMBL1201777 TAPENTADOL HYDROCHLORIDE Mu opioid receptor agonist DailyMed
CHEMBL1237065 TRAMADOL HYDROCHLORIDE Mu opioid receptor agonist DailyMed
More...

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000112038
Ensembl ENSG00000112038
GO Cellular Component GO:0005783 (endoplasmic reticulum)
GO:0005794 (Golgi apparatus)
GO:0005887 (integral to plasma membrane)
GO Molecular Function GO:0004988 (mu-opioid receptor activity)
GO:0005515 (protein binding)
GO Biological Process GO:0007600 (sensory perception)
GO:0007610 (behavior)
GO:0008285 (negative regulation of cell proliferation)
Wikipedia Mu_Opioid_receptor

Target Cross References - Protein

canSAR P35372
Human Protein Atlas ENSG00000112038
IntAct P35372
Guide to Pharmacology 319 (Mu;)
MICAD NBK23273 (Mu opioid receptor)
PharmGKB PA31945
Reactome REACT_14797 (Signaling by GPCR.)
REACT_15295 (Opioid Signalling.)
UniProt B2R9S7 B8Q1L7 P35372 Q12930 Q4VWM1 Q4VWM2 Q4VWM3 Q4VWM4 Q4VWM6 Q4VWX6 Q5TDA1 Q6UQ80 Q7Z2D8 Q8IWW3 Q8IWW4 Q9UCZ4 Q9UN57

Target Cross References - Domain

InterPro IPR000105 (Mu_opioid_rcpt.)
IPR000276 (7TM_GPCR_Rhodpsn.)
IPR001418 (Opioid_rcpt.)
IPR017452 (GPCR_Rhodpsn_supfam.)
Pfam PF00001 (7tm_1)
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