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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2327
Target Type SINGLE PROTEIN
Preferred Name Neurokinin 2 receptor
Synonyms NK-2 receptor | NK-2R | NK2R | NKNAR | Neurokinin A receptor | SKR | Substance-K receptor | TAC2R | TACR2 | Tachykinin receptor 2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > peptide receptor (family a gpcr) > short peptide receptor (family a gpcr) > neurokinin receptor

Target Components

Component Description Relationship Accession
Substance-K receptor SINGLE PROTEIN P21452

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000075073
Ensembl ENSG00000075073
GO Cellular Component GO:0005887 (integral to plasma membrane)
GO Molecular Function GO:0004995 (tachykinin receptor activity)
GO Biological Process GO:0006936 (muscle contraction)
GO:0007588 (excretion)
Wikipedia Tachykinin_receptor_2

Target Cross References - Protein

canSAR P21452
Human Protein Atlas ENSG00000075073
Guide to Pharmacology 361 (NK2)
PharmGKB PA36303
Reactome REACT_14797 (Signaling by GPCR.)
UniProt A8K7I1 P21452 Q4QRI5 Q8NGQ8 Q9UDE6 Q9UDE7

Target Cross References - Domain

InterPro IPR000276 (7TM_GPCR_Rhodpsn.)
IPR000913 (NK2_rcpt.)
IPR001681 (Neurokn_rcpt.)
IPR017452 (GPCR_Rhodpsn_supfam.)
Pfam PF00001 (7tm_1)
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