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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2326
Target Type SINGLE PROTEIN
Preferred Name Carbonic anhydrase VII
Synonyms CA-VII | CA7 | Carbonate dehydratase VII | Carbonic anhydrase 7 | Carbonic anhydrase VII
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > lyase

Target Components

Component Description Relationship Accession
Carbonic anhydrase 7 SINGLE PROTEIN P43166

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2095180 Carbonic anhydrase PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL19 METHAZOLAMIDE Carbonic anhydrase VII inhibitor 4 DailyMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000168748
Ensembl ENSG00000168748
GO Cellular Component GO:0005829 (cytosol)
GO Molecular Function GO:0004089 (carbonate dehydratase activity)
GO:0008270 (zinc ion binding)
GO Biological Process GO:0032230 (positive regulation of synaptic transmission, GABAergic)
GO:0098792 (xenophagy)
GO:0044281 (small molecule metabolic process)
GO:0006730 (one-carbon metabolic process)
GO:0015701 (bicarbonate transport)
GO:0002230 (positive regulation of defense response to virus by host)
GO:0032849 (positive regulation of cellular pH reduction)
GO:0098779 (mitophagy in response to mitochondrial depolarization)
GO:2001225 (regulation of chloride transport)
Wikipedia Carbonic_anhydrase_7

Target Cross References - Protein

canSAR P43166
Human Protein Atlas ENSG00000168748
Guide to Pharmacology 2749 (carbonic anhydrase VII)
PharmGKB PA25996
UniProt P43166 Q541F0

Target Cross References - Domain

InterPro IPR018338 (Carbonic_anhydrase_a-class_CS.)
IPR018438 (Carbonic_anhydrase_CA7.)
IPR001148 (Carbonic_anhydrase_a.)
IPR023561 (Carbonic_anhydrase_a-class.)
Pfam PF00194 (Carb_anhydrase)

Target Cross References - Structure

PDBe 3ML5 3MDZ
CREDO 3ML5 3MDZ
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