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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL232
Target Type SINGLE PROTEIN
Preferred Name Alpha-1b adrenergic receptor
Synonyms ADRA1B | Alpha-1B adrenergic receptor | Alpha-1B adrenoceptor | Alpha-1B adrenoreceptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > monoamine receptor > adrenergic receptor

Target Components

Component Description Relationship Accession
Alpha-1B adrenergic receptor SINGLE PROTEIN P35368

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2094251 Adrenergic receptor alpha-1 PROTEIN FAMILY
CHEMBL2095203 Adrenergic receptor alpha PROTEIN FAMILY
CHEMBL2331074 Adrenergic receptor PROTEIN FAMILY
CHEMBL2096676 Adrenergic receptors; alpha-1 A & B SELECTIVITY GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000170214
Ensembl ENSG00000170214
GO Cellular Component GO:0005634 (nucleus)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0031965 (nuclear membrane)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004935 (adrenergic receptor activity)
GO:0004937 (alpha1-adrenergic receptor activity)
GO:0046982 (protein heterodimerization activity)
GO Biological Process GO:0001994 (norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure)
GO:0006937 (regulation of muscle contraction)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007188 (adenylate cyclase-modulating G-protein coupled receptor signaling pathway)
GO:0007200 (phospholipase C-activating G-protein coupled receptor signaling pathway)
GO:0007204 (positive regulation of cytosolic calcium ion concentration)
GO:0007267 (cell-cell signaling)
GO:0007275 (multicellular organism development)
GO:0008283 (cell proliferation)
GO:0019229 (regulation of vasoconstriction)
GO:0035556 (intracellular signal transduction)
GO:0042593 (glucose homeostasis)
GO:0043410 (positive regulation of MAPK cascade)
GO:0045907 (positive regulation of vasoconstriction)
GO:0045987 (positive regulation of smooth muscle contraction)
GO:0055117 (regulation of cardiac muscle contraction)
GO:0071880 (adenylate cyclase-activating adrenergic receptor signaling pathway)
Wikipedia Alpha-1B_adrenergic_receptor

Target Cross References - Protein

canSAR P35368
Human Protein Atlas ENSG00000170214
IntAct P35368
Guide to Pharmacology 23
Open Targets ENSG00000170214
PharmGKB PA33
Pharos P35368 (Tclin)
Reactome R-HSA-390696 (Adrenoceptors.)
R-HSA-416476 (G alpha (q) signalling events.)
R-HSA-416482 (G alpha (12/13) signalling events.)
UniProt B0LPE1 P35368

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR001115 (ADRA1B_rcpt.)
IPR002233 (ADR_fam.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)
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