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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2318
Target Type SINGLE PROTEIN
Preferred Name ADAMTS4
Synonyms A disintegrin and metalloproteinase with thrombospondin motifs 4 | ADAM-TS 4 | ADAM-TS4 | ADAMTS-4 | ADAMTS4 | ADMP-1 | Aggrecanase-1 | KIAA0688
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > metallo protease > metallo protease mam clan > metallo protease m12b subfamily

Target Components

Component Description Relationship Accession
A disintegrin and metalloproteinase with thrombospondin motifs 4 SINGLE PROTEIN O75173

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000158859
Ensembl ENSG00000158859
GO Cellular Component GO:0005578 (proteinaceous extracellular matrix)
GO:0005615 (extracellular space)
GO Molecular Function GO:0002020 (protease binding)
GO:0004222 (metalloendopeptidase activity)
GO:0008270 (zinc ion binding)
GO Biological Process GO:0001501 (skeletal system development)
GO:0006508 (proteolysis)
Wikipedia ADAMTS4

Target Cross References - Protein

Human Protein Atlas ENSG00000158859
PharmGKB PA24548
UniProt O75173 Q5VTW2 Q6P4Q8 Q6UWA8 Q9UN83

Target Cross References - Domain

InterPro IPR000884 (Thrombospondin_1_rpt.)
IPR001590 (Peptidase_M12B.)
IPR002870 (Peptidase_M12B_N.)
IPR010294 (ADAM_spacer1.)
IPR013273 (Peptidase_M12B_ADAM-TS.)
Pfam PF00090 (TSP_1)
PF01421 (Reprolysin)
PF01562 (Pep_M12B_propep)
PF05986 (ADAM_spacer1)

Target Cross References - Structure

PDBe 2RJP 3B2Z
CREDO 2RJP 3B2Z
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