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Target Report Card

Target Name and Classification

Target ID CHEMBL2318
Target Type SINGLE PROTEIN
Preferred Name ADAMTS4
Synonyms A disintegrin and metalloproteinase with thrombospondin motifs 4 | ADAM-TS 4 | ADAM-TS4 | ADAMTS-4 | ADAMTS4 | ADMP-1 | Aggrecanase-1 | KIAA0688
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > metallo protease > metallo protease mam clan > metallo protease m12b subfamily

Target Components

Component Description Relationship Accession
A disintegrin and metalloproteinase with thrombospondin motifs 4 SINGLE PROTEIN O75173

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000158859
Ensembl ENSG00000158859
GO Cellular Component GO:0005576 (extracellular region)
GO:0005578 (proteinaceous extracellular matrix)
GO:0005615 (extracellular space)
GO:0031012 (extracellular matrix)
GO Molecular Function GO:0002020 (protease binding)
GO:0004222 (metalloendopeptidase activity)
GO:0005515 (protein binding)
GO:0008233 (peptidase activity)
GO:0008237 (metallopeptidase activity)
GO:0008270 (zinc ion binding)
GO:0016787 (hydrolase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0001501 (skeletal system development)
GO:0006508 (proteolysis)
GO:0022617 (extracellular matrix disassembly)
Wikipedia ADAMTS4

Target Cross References - Protein

Human Protein Atlas ENSG00000158859
IntAct O75173
Guide to Pharmacology 1677
Open Targets ENSG00000158859
PharmGKB PA24548
Reactome R-HSA-1474228 (Degradation of the extracellular matrix.)
R-HSA-5083635 (Defective B3GALTL causes Peters-plus syndrome (PpS).)
R-HSA-5173214 (O-glycosylation of TSR domain-containing proteins.)
UniProt O75173 Q2HYD0 Q5VTW2 Q6P4Q8 Q6UWA8 Q9UN83

Target Cross References - Domain

InterPro IPR000884 (TSP1_rpt.)
IPR001590 (Peptidase_M12B.)
IPR002870 (Peptidase_M12B_N.)
IPR006586 (ADAM_Cys-rich.)
IPR010294 (ADAM_spacer1.)
IPR013273 (Peptidase_M12B_ADAM-TS.)
IPR024079 (MetalloPept_cat_dom.)
Pfam PF00090 (TSP_1)
PF01421 (Reprolysin)
PF01562 (Pep_M12B_propep)
PF05986 (ADAM_spacer1)

Target Cross References - Structure

PDBe 2RJP 3B2Z 4WK7 4WKE 4WKI
CREDO 2RJP 3B2Z 4WK7 4WKE 4WKI
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