ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL2310
Target Type SINGLE PROTEIN
Preferred Name Insulin-like growth factor binding protein 4
Synonyms IBP-4 | IBP4 | IGF-binding protein 4 | IGFBP-4 | IGFBP4 | Insulin-like growth factor-binding protein 4
Organism Homo sapiens
Species Group No
Protein Target Classification
  • secreted protein

Target Components

Component Description Relationship Accession
Insulin-like growth factor-binding protein 4 SINGLE PROTEIN P22692

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000141753
Ensembl ENSG00000141753
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO Molecular Function GO:0005102 (receptor binding)
GO:0005520 (insulin-like growth factor binding)
GO:0019838 (growth factor binding)
GO:0031994 (insulin-like growth factor I binding)
GO:0031995 (insulin-like growth factor II binding)
GO Biological Process GO:0001501 (skeletal system development)
GO:0001558 (regulation of cell growth)
GO:0006259 (DNA metabolic process)
GO:0006954 (inflammatory response)
GO:0007165 (signal transduction)
GO:0008283 (cell proliferation)
GO:0010906 (regulation of glucose metabolic process)
GO:0040008 (regulation of growth)
GO:0043410 (positive regulation of MAPK cascade)
GO:0043567 (regulation of insulin-like growth factor receptor signaling pathway)
GO:0043568 (positive regulation of insulin-like growth factor receptor signaling pathway)
GO:0044267 (cellular protein metabolic process)
GO:0044342 (type B pancreatic cell proliferation)
GO:0090090 (negative regulation of canonical Wnt signaling pathway)
Wikipedia IGFBP4

Target Cross References - Protein

canSAR P22692
Human Protein Atlas ENSG00000141753
IntAct P22692
Open Targets ENSG00000141753
PharmGKB PA29706
Reactome R-HSA-381426 (Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).)
UniProt A0N9W2 B4E351 P22692 Q5U012 Q9UCL6

Target Cross References - Domain

InterPro IPR000716 (Thyroglobulin_1.)
IPR000867 (IGFBP-like.)
IPR009030 (Growth_fac_rcpt_.)
IPR009168 (IGFBP1-6.)
IPR017891 (Insulin_GF-bd_Cys-rich_CS.)
IPR022321 (IGFBP_1-6_chordata.)
IPR022327 (IGFBP-4.)
Pfam PF00086 (Thyroglobulin_1)
PF00219 (IGFBP)

Target Cross References - Structure

PDBe 1WQJ 2DSP 2DSQ 2DSR
CREDO 1WQJ 2DSP 2DSQ 2DSR
spacer
spacer