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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2309
Target Type SINGLE PROTEIN
Preferred Name Voltage-gated potassium channel subunit Kv1.1
Synonyms KCNA1 | Potassium voltage-gated channel subfamily A member 1 | Voltage-gated K(+) channel HuKI | Voltage-gated potassium channel HBK1 | Voltage-gated potassium channel subunit Kv1.1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > voltage-gated ion channel > potassium channels > voltage-gated potassium channel

Target Components

Component Description Relationship Accession
Potassium voltage-gated channel subfamily A member 1 SINGLE PROTEIN Q09470

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2362996 Voltage-gated potassium channel PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000111262
Ensembl ENSG00000111262
GO Cellular Component GO:0005783 (endoplasmic reticulum)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0008076 (voltage-gated potassium channel complex)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016023 (cytoplasmic, membrane-bounded vesicle)
GO:0016324 (apical plasma membrane)
GO:0030054 (cell junction)
GO:0030424 (axon)
GO:0030425 (dendrite)
GO:0031410 (cytoplasmic vesicle)
GO:0033270 (paranode region of axon)
GO:0034705 (potassium channel complex)
GO:0042734 (presynaptic membrane)
GO:0042995 (cell projection)
GO:0043025 (neuronal cell body)
GO:0043204 (perikaryon)
GO:0043679 (axon terminus)
GO:0044224 (juxtaparanode region of axon)
GO:0045202 (synapse)
GO Molecular Function GO:0005216 (ion channel activity)
GO:0005244 (voltage-gated ion channel activity)
GO:0005249 (voltage-gated potassium channel activity)
GO:0005251 (delayed rectifier potassium channel activity)
GO:0005267 (potassium channel activity)
GO:0005515 (protein binding)
GO:0015079 (potassium ion transmembrane transporter activity)
GO Biological Process GO:0001964 (startle response)
GO:0006810 (transport)
GO:0006811 (ion transport)
GO:0006813 (potassium ion transport)
GO:0006937 (regulation of muscle contraction)
GO:0007268 (chemical synaptic transmission)
GO:0007405 (neuroblast proliferation)
GO:0007420 (brain development)
GO:0010644 (cell communication by electrical coupling)
GO:0010960 (magnesium ion homeostasis)
GO:0019228 (neuronal action potential)
GO:0021766 (hippocampus development)
GO:0023041 (neuronal signal transduction)
GO:0034613 (cellular protein localization)
GO:0034765 (regulation of ion transmembrane transport)
GO:0042391 (regulation of membrane potential)
GO:0050905 (neuromuscular process)
GO:0050966 (detection of mechanical stimulus involved in sensory perception of pain)
GO:0050976 (detection of mechanical stimulus involved in sensory perception of touch)
GO:0051260 (protein homooligomerization)
GO:0055085 (transmembrane transport)
GO:0071286 (cellular response to magnesium ion)
GO:0071805 (potassium ion transmembrane transport)
Wikipedia Kv1.1

Target Cross References - Protein

canSAR Q09470
CGD Episodic ataxia/myokymia syndrome
Human Protein Atlas ENSG00000111262
IntAct Q09470
Guide to Pharmacology 538
Open Targets ENSG00000111262
PharmGKB PA30019
Pharos Q09470 (Tclin)
Reactome R-HSA-1296072 (Voltage gated Potassium channels.)
UniProt A6NM83 Q09470 Q3MIQ9

Target Cross References - Domain

InterPro IPR000210 (BTB/POZ_dom.)
IPR003131 (T1-type_BTB.)
IPR003968 (K_chnl_volt-dep_Kv.)
IPR003972 (K_chnl_volt-dep_Kv1.)
IPR004048 (K_chnl_volt-dep_Kv1.1.)
IPR005821 (Ion_trans_dom.)
IPR011333 (SKP1/BTB/POZ.)
IPR027359 (Channel_four-helix_dom.)
IPR028325 (VG_K_chnl.)
Pfam PF00520 (Ion_trans)
PF02214 (BTB_2)
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