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Target Report Card

Target Name and Classification

Target ID CHEMBL230
Target Type SINGLE PROTEIN
Preferred Name Cyclooxygenase-2
Synonyms Object
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > oxidoreductase

Target Components

Component Description Relationship Accession
Prostaglandin G/H synthase 2 SINGLE PROTEIN P35354

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2094253 Cyclooxygenase PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000073756
Ensembl ENSG00000073756
GO Cellular Component GO:0043005 (neuron projection)
GO:0005634 (nucleus)
GO:0005788 (endoplasmic reticulum lumen)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005901 (caveola)
GO:0043234 (protein complex)
GO:0005737 (cytoplasm)
GO:0005783 (endoplasmic reticulum)
GO Molecular Function GO:0019899 (enzyme binding)
GO:0046872 (metal ion binding)
GO:0004601 (peroxidase activity)
GO:0008289 (lipid binding)
GO:0050473 (arachidonate 15-lipoxygenase activity)
GO:0004666 (prostaglandin-endoperoxide synthase activity)
GO:0020037 (heme binding)
GO Biological Process GO:0001516 (prostaglandin biosynthetic process)
GO:0007613 (memory)
GO:0010226 (response to lithium ion)
GO:0031394 (positive regulation of prostaglandin biosynthetic process)
GO:0033280 (response to vitamin D)
GO:0042633 (hair cycle)
GO:0045786 (negative regulation of cell cycle)
GO:0045907 (positive regulation of vasoconstriction)
GO:0045986 (negative regulation of smooth muscle contraction)
GO:0071456 (cellular response to hypoxia)
GO:0090050 (positive regulation of cell migration involved in sprouting angiogenesis)
GO:0090271 (positive regulation of fibroblast growth factor production)
GO:0090362 (positive regulation of platelet-derived growth factor production)
GO:0019369 (arachidonic acid metabolic process)
GO:0042346 (positive regulation of NF-kappaB import into nucleus)
GO:0042493 (response to drug)
GO:0044281 (small molecule metabolic process)
GO:0050727 (regulation of inflammatory response)
GO:0071318 (cellular response to ATP)
GO:0006766 (vitamin metabolic process)
GO:0007612 (learning)
GO:0010575 (positive regulation of vascular endothelial growth factor production)
GO:0019372 (lipoxygenase pathway)
GO:0019674 (NAD metabolic process)
GO:0030728 (ovulation)
GO:0031915 (positive regulation of synaptic plasticity)
GO:0034612 (response to tumor necrosis factor)
GO:0035633 (maintenance of blood-brain barrier)
GO:0046697 (decidualization)
GO:0070542 (response to fatty acid)
GO:0006693 (prostaglandin metabolic process)
GO:0006954 (inflammatory response)
GO:0008217 (regulation of blood pressure)
GO:0010042 (response to manganese ion)
GO:0045987 (positive regulation of smooth muscle contraction)
GO:0050873 (brown fat cell differentiation)
GO:0051926 (negative regulation of calcium ion transport)
GO:0008285 (negative regulation of cell proliferation)
GO:0032355 (response to estradiol)
GO:0034644 (cellular response to UV)
GO:0045429 (positive regulation of nitric oxide biosynthetic process)
GO:0048661 (positive regulation of smooth muscle cell proliferation)
GO:0051968 (positive regulation of synaptic transmission, glutamatergic)
GO:0009750 (response to fructose)
GO:0019233 (sensory perception of pain)
GO:0019371 (cyclooxygenase pathway)
GO:0043065 (positive regulation of apoptotic process)
GO:0090336 (positive regulation of brown fat cell differentiation)
GO:0001525 (angiogenesis)
GO:0006769 (nicotinamide metabolic process)
GO:0006928 (movement of cell or subcellular component)
GO:0007566 (embryo implantation)
GO:0031622 (positive regulation of fever generation)
GO:0032227 (negative regulation of synaptic transmission, dopaminergic)
GO:0051384 (response to glucocorticoid)
GO:0071260 (cellular response to mechanical stimulus)
GO:0071636 (positive regulation of transforming growth factor beta production)
GO:0006767 (water-soluble vitamin metabolic process)
GO:0006979 (response to oxidative stress)
GO:0030282 (bone mineralization)
GO:0032496 (response to lipopolysaccharide)
GO:0071498 (cellular response to fluid shear stress)
Wikipedia Prostaglandin-endoperoxide_synthase_2

Target Cross References - Protein

canSAR P35354
Human Protein Atlas ENSG00000073756
IntAct P35354
Guide to Pharmacology 1376 (COX-2)
PharmGKB PA293
UniProt A8K802 P35354 Q16876

Target Cross References - Domain

InterPro IPR000742 (EGF-like_dom.)
IPR029576 (COX-2.)
IPR019791 (Haem_peroxidase_animal.)
IPR010255 (Haem_peroxidase.)
Pfam PF00008 (EGF)
PF03098 (An_peroxidase)
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