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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL230
Preferred Name Cyclooxygenase-2
Synonyms COX-2 | COX2 | Cyclooxygenase-2 | PGH synthase 2 | PGHS-2 | PHS II | PTGS2 | Prostaglandin G/H synthase 2 | Prostaglandin H2 synthase 2 | Prostaglandin-endoperoxide synthase 2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > oxidoreductase

Target Components

Component Description Relationship Accession
Prostaglandin G/H synthase 2 SINGLE PROTEIN P35354

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2094253 Cyclooxygenase PROTEIN FAMILY

Approved Drugs

ChEMBL ID Name Mechanism of Action References
CHEMBL1316 CARPROFEN Cyclooxygenase-2 inhibitor DailyMed
CHEMBL118 CELECOXIB Cyclooxygenase-2 inhibitor DailyMed
CHEMBL622 ETODOLAC Cyclooxygenase-2 inhibitor PubMed
CHEMBL599 MELOXICAM Cyclooxygenase-2 inhibitor PubMed
CHEMBL1070 NABUMETONE Cyclooxygenase-2 inhibitor DailyMed
CHEMBL122 ROFECOXIB Cyclooxygenase-2 inhibitor FDA
CHEMBL865 VALDECOXIB Cyclooxygenase-2 inhibitor DailyMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000073756
Ensembl ENSG00000073756
GO Cellular Component GO:0005634 (nucleus)
GO:0005788 (endoplasmic reticulum lumen)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005792 (microsome)
GO:0043005 (neuron projection)
GO Molecular Function GO:0004601 (peroxidase activity)
GO:0004666 (prostaglandin-endoperoxide synthase activity)
GO:0016702 (oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen)
GO:0019899 (enzyme binding)
GO:0020037 (heme binding)
GO Biological Process GO:0006805 (xenobiotic metabolic process)
GO:0006928 (cellular component movement)
GO:0006979 (response to oxidative stress)
GO:0008217 (regulation of blood pressure)
GO:0010575 (positive regulation vascular endothelial growth factor production)
GO:0019371 (cyclooxygenase pathway)
GO:0031394 (positive regulation of prostaglandin biosynthetic process)
GO:0031622 (positive regulation of fever generation)
GO:0042446 (hormone biosynthetic process)
GO:0045429 (positive regulation of nitric oxide biosynthetic process)
GO:0071636 (positive regulation of transforming growth factor-beta production)
GO:0090050 (positive regulation of cell migration involved in sprouting angiogenesis)
GO:0090271 (positive regulation of fibroblast growth factor production)
GO:0090336 (positive regulation of brown fat cell differentiation)
GO:0090362 (positive regulation of platelet-derived growth factor production)
Wikipedia Prostaglandin-endoperoxide_synthase_2

Target Cross References - Protein

canSAR P35354
Human Protein Atlas ENSG00000073756
Guide to Pharmacology 1376 (COX-2)
PharmGKB PA293
Reactome REACT_13433 (Biological oxidations.)
REACT_15314 (Hormone biosynthesis.)
REACT_22258 (Metabolism of lipids and lipoproteins.)
UniProt A8K802 P35354 Q16876

Target Cross References - Domain

InterPro IPR000742 (EGF_3.)
IPR002007 (Haem_peroxidase_animal.)
IPR006210 (EGF-like.)
IPR010255 (Haem_peroxidase.)
IPR019791 (Haem_peroxidase_animal_subgr.)
Pfam PF03098 (An_peroxidase)