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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL230
Preferred Name Cyclooxygenase-2
Synonyms COX-2 | COX2 | Cyclooxygenase-2 | PGH synthase 2 | PGHS-2 | PHS II | PTGS2 | Prostaglandin G/H synthase 2 | Prostaglandin H2 synthase 2 | Prostaglandin-endoperoxide synthase 2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > oxidoreductase

Target Components

Component Description Relationship Accession
Prostaglandin G/H synthase 2 SINGLE PROTEIN P35354

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2094253 Cyclooxygenase PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL118 CELECOXIB Cyclooxygenase-2 inhibitor 4 DailyMed
CHEMBL599 MELOXICAM Cyclooxygenase-2 inhibitor 4 PubMed
CHEMBL122 ROFECOXIB Cyclooxygenase-2 inhibitor 4 FDA
CHEMBL622 ETODOLAC Cyclooxygenase-2 inhibitor 4 PubMed
CHEMBL865 VALDECOXIB Cyclooxygenase-2 inhibitor 4 DailyMed
CHEMBL1070 NABUMETONE Cyclooxygenase-2 inhibitor 4 DailyMed
CHEMBL1316 CARPROFEN Cyclooxygenase-2 inhibitor 4 DailyMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000073756
Ensembl ENSG00000073756
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005783 (endoplasmic reticulum)
GO:0005788 (endoplasmic reticulum lumen)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005792 (microsome)
GO:0005901 (caveola)
GO:0043005 (neuron projection)
GO:0043234 (protein complex)
GO Molecular Function GO:0004601 (peroxidase activity)
GO:0004666 (prostaglandin-endoperoxide synthase activity)
GO:0008289 (lipid binding)
GO:0016702 (oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen)
GO:0019899 (enzyme binding)
GO:0020037 (heme binding)
GO:0046872 (metal ion binding)
GO:0050473 (arachidonate 15-lipoxygenase activity)
GO Biological Process GO:0001516 (prostaglandin biosynthetic process)
GO:0001525 (angiogenesis)
GO:0006693 (prostaglandin metabolic process)
GO:0006766 (vitamin metabolic process)
GO:0006767 (water-soluble vitamin metabolic process)
GO:0006769 (nicotinamide metabolic process)
GO:0006805 (xenobiotic metabolic process)
GO:0006928 (cellular component movement)
GO:0006928 (movement of cell or subcellular component)
GO:0006954 (inflammatory response)
GO:0006979 (response to oxidative stress)
GO:0007566 (embryo implantation)
GO:0007612 (learning)
GO:0007613 (memory)
GO:0008217 (regulation of blood pressure)
GO:0008285 (negative regulation of cell proliferation)
GO:0009750 (response to fructose)
GO:0010042 (response to manganese ion)
GO:0010226 (response to lithium ion)
GO:0010575 (positive regulation of vascular endothelial growth factor production)
GO:0010575 (positive regulation vascular endothelial growth factor production)
GO:0019233 (sensory perception of pain)
GO:0019369 (arachidonic acid metabolic process)
GO:0019371 (cyclooxygenase pathway)
GO:0019372 (lipoxygenase pathway)
GO:0019674 (NAD metabolic process)
GO:0030282 (bone mineralization)
GO:0030728 (ovulation)
GO:0031394 (positive regulation of prostaglandin biosynthetic process)
GO:0031622 (positive regulation of fever generation)
GO:0031915 (positive regulation of synaptic plasticity)
GO:0032227 (negative regulation of synaptic transmission, dopaminergic)
GO:0032355 (response to estradiol)
GO:0032496 (response to lipopolysaccharide)
GO:0033280 (response to vitamin D)
GO:0034612 (response to tumor necrosis factor)
GO:0034644 (cellular response to UV)
GO:0035633 (maintenance of blood-brain barrier)
GO:0042346 (positive regulation of NF-kappaB import into nucleus)
GO:0042446 (hormone biosynthetic process)
GO:0042493 (response to drug)
GO:0042633 (hair cycle)
GO:0043065 (positive regulation of apoptotic process)
GO:0044281 (small molecule metabolic process)
GO:0045429 (positive regulation of nitric oxide biosynthetic process)
GO:0045786 (negative regulation of cell cycle)
GO:0045907 (positive regulation of vasoconstriction)
GO:0045986 (negative regulation of smooth muscle contraction)
GO:0045987 (positive regulation of smooth muscle contraction)
GO:0046697 (decidualization)
GO:0048661 (positive regulation of smooth muscle cell proliferation)
GO:0050727 (regulation of inflammatory response)
GO:0050873 (brown fat cell differentiation)
GO:0051384 (response to glucocorticoid)
GO:0051926 (negative regulation of calcium ion transport)
GO:0051968 (positive regulation of synaptic transmission, glutamatergic)
GO:0070542 (response to fatty acid)
GO:0071260 (cellular response to mechanical stimulus)
GO:0071318 (cellular response to ATP)
GO:0071456 (cellular response to hypoxia)
GO:0071498 (cellular response to fluid shear stress)
GO:0071636 (positive regulation of transforming growth factor beta production)
GO:0071636 (positive regulation of transforming growth factor-beta production)
GO:0090050 (positive regulation of cell migration involved in sprouting angiogenesis)
GO:0090271 (positive regulation of fibroblast growth factor production)
GO:0090336 (positive regulation of brown fat cell differentiation)
GO:0090362 (positive regulation of platelet-derived growth factor production)
Wikipedia Prostaglandin-endoperoxide_synthase_2

Target Cross References - Protein

canSAR P35354
Human Protein Atlas ENSG00000073756
IntAct P35354
PharmGKB PA293
UniProt A8K802 P35354 Q16876

Target Cross References - Domain

InterPro IPR000742 (EGF-like_dom.)
IPR000742 (EGF_3.)
IPR002007 (Haem_peroxidase_animal.)
IPR006210 (EGF-like.)
IPR010255 (Haem_peroxidase.)
IPR019791 (Haem_peroxidase_animal.)
IPR019791 (Haem_peroxidase_animal_subgr.)
IPR029576 (COX-2.)
Pfam PF00008 (EGF)
PF03098 (An_peroxidase)