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Target Report Card

Target Name and Classification

Target ID CHEMBL230
Preferred Name Cyclooxygenase-2
Synonyms COX-2 | COX2 | Cyclooxygenase-2 | PGH synthase 2 | PGHS-2 | PHS II | PTGS2 | Prostaglandin G/H synthase 2 | Prostaglandin H2 synthase 2 | Prostaglandin-endoperoxide synthase 2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > oxidoreductase

Target Components

Component Description Relationship Accession
Prostaglandin G/H synthase 2 SINGLE PROTEIN P35354

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2094253 Cyclooxygenase PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL416146 ETORICOXIB Cyclooxygenase-2 inhibitor 4 PubMed
CHEMBL118 CELECOXIB Cyclooxygenase-2 inhibitor 4 DailyMed
CHEMBL599 MELOXICAM Cyclooxygenase-2 inhibitor 4 PubMed
CHEMBL122 ROFECOXIB Cyclooxygenase-2 inhibitor 4 FDA
CHEMBL622 ETODOLAC Cyclooxygenase-2 inhibitor 4 PubMed
CHEMBL865 VALDECOXIB Cyclooxygenase-2 inhibitor 4 DailyMed
CHEMBL1070 NABUMETONE Cyclooxygenase-2 inhibitor 4 DailyMed
CHEMBL1316 CARPROFEN Cyclooxygenase-2 inhibitor 4 DailyMed DailyMed
CHEMBL166863 POLMACOXIB Cyclooxygenase-2 inhibitor 3 PubMed PubMed
CHEMBL1835207 APRICOXIB Cyclooxygenase-2 inhibitor 2 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000073756
Ensembl ENSG00000073756
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005783 (endoplasmic reticulum)
GO:0005788 (endoplasmic reticulum lumen)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005901 (caveola)
GO:0016020 (membrane)
GO:0031090 (organelle membrane)
GO:0043005 (neuron projection)
GO:0043231 (intracellular membrane-bounded organelle)
GO:0043234 (protein complex)
GO Molecular Function GO:0004601 (peroxidase activity)
GO:0004666 (prostaglandin-endoperoxide synthase activity)
GO:0005515 (protein binding)
GO:0008289 (lipid binding)
GO:0016491 (oxidoreductase activity)
GO:0016702 (oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen)
GO:0019899 (enzyme binding)
GO:0020037 (heme binding)
GO:0042803 (protein homodimerization activity)
GO:0046872 (metal ion binding)
GO:0050473 (arachidonate 15-lipoxygenase activity)
GO:0051213 (dioxygenase activity)
GO Biological Process GO:0001516 (prostaglandin biosynthetic process)
GO:0001525 (angiogenesis)
GO:0006629 (lipid metabolic process)
GO:0006631 (fatty acid metabolic process)
GO:0006633 (fatty acid biosynthetic process)
GO:0006693 (prostaglandin metabolic process)
GO:0006769 (nicotinamide metabolic process)
GO:0006928 (movement of cell or subcellular component)
GO:0006954 (inflammatory response)
GO:0006979 (response to oxidative stress)
GO:0007566 (embryo implantation)
GO:0007612 (learning)
GO:0007613 (memory)
GO:0008217 (regulation of blood pressure)
GO:0008284 (positive regulation of cell proliferation)
GO:0008285 (negative regulation of cell proliferation)
GO:0009314 (response to radiation)
GO:0009750 (response to fructose)
GO:0010033 (response to organic substance)
GO:0010042 (response to manganese ion)
GO:0010226 (response to lithium ion)
GO:0010243 (response to organonitrogen compound)
GO:0010575 (positive regulation of vascular endothelial growth factor production)
GO:0010942 (positive regulation of cell death)
GO:0014070 (response to organic cyclic compound)
GO:0019233 (sensory perception of pain)
GO:0019371 (cyclooxygenase pathway)
GO:0019372 (lipoxygenase pathway)
GO:0030282 (bone mineralization)
GO:0030728 (ovulation)
GO:0031394 (positive regulation of prostaglandin biosynthetic process)
GO:0031622 (positive regulation of fever generation)
GO:0031915 (positive regulation of synaptic plasticity)
GO:0032227 (negative regulation of synaptic transmission, dopaminergic)
GO:0032355 (response to estradiol)
GO:0032496 (response to lipopolysaccharide)
GO:0033280 (response to vitamin D)
GO:0034097 (response to cytokine)
GO:0034612 (response to tumor necrosis factor)
GO:0034644 (cellular response to UV)
GO:0035633 (maintenance of blood-brain barrier)
GO:0042127 (regulation of cell proliferation)
GO:0042346 (positive regulation of NF-kappaB import into nucleus)
GO:0042493 (response to drug)
GO:0042633 (hair cycle)
GO:0043065 (positive regulation of apoptotic process)
GO:0045429 (positive regulation of nitric oxide biosynthetic process)
GO:0045786 (negative regulation of cell cycle)
GO:0045907 (positive regulation of vasoconstriction)
GO:0045986 (negative regulation of smooth muscle contraction)
GO:0045987 (positive regulation of smooth muscle contraction)
GO:0046697 (decidualization)
GO:0048661 (positive regulation of smooth muscle cell proliferation)
GO:0050727 (regulation of inflammatory response)
GO:0050873 (brown fat cell differentiation)
GO:0051384 (response to glucocorticoid)
GO:0051926 (negative regulation of calcium ion transport)
GO:0051968 (positive regulation of synaptic transmission, glutamatergic)
GO:0055114 (oxidation-reduction process)
GO:0070542 (response to fatty acid)
GO:0071260 (cellular response to mechanical stimulus)
GO:0071318 (cellular response to ATP)
GO:0071456 (cellular response to hypoxia)
GO:0071498 (cellular response to fluid shear stress)
GO:0071636 (positive regulation of transforming growth factor beta production)
GO:0090050 (positive regulation of cell migration involved in sprouting angiogenesis)
GO:0090271 (positive regulation of fibroblast growth factor production)
GO:0090336 (positive regulation of brown fat cell differentiation)
GO:0090362 (positive regulation of platelet-derived growth factor production)
GO:0098869 (cellular oxidant detoxification)
Wikipedia Prostaglandin-endoperoxide_synthase_2

Target Cross References - Protein

canSAR P35354
Human Protein Atlas ENSG00000073756
IntAct P35354
Guide to Pharmacology 1376
Open Targets ENSG00000073756
PharmGKB PA293
Reactome R-HSA-197264 (Nicotinamide salvaging.)
R-HSA-2142770 (Synthesis of 15-eicosatetraenoic acid derivatives.)
R-HSA-2162123 (Synthesis of Prostaglandins (PG) and Thromboxanes (TX).)
R-HSA-6783783 (Interleukin-10 signaling.)
R-HSA-6785807 (Interleukin-4 and 13 signaling.)
UniProt A8K802 P35354 Q16876

Target Cross References - Domain

InterPro IPR000742 (EGF-like_dom.)
IPR010255 (Haem_peroxidase.)
IPR019791 (Haem_peroxidase_animal.)
IPR029576 (COX-2.)
Pfam PF00008 (EGF)
PF03098 (An_peroxidase)

Target Cross References - Structure