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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2292
Target Type SINGLE PROTEIN
Preferred Name Dual-specificity tyrosine-phosphorylation regulated kinase 1A
Synonyms DYRK | DYRK1A | Dual specificity YAK1-related kinase | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | HP86 | MNB | MNBH | MNBH | Protein kinase minibrain homolog | hMNB
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > cmgc protein kinase group > cmgc protein kinase dyrk family > cmgc protein kinase dyrk1 subfamily

Target Components

Component Description Relationship Accession
Dual specificity tyrosine-phosphorylation-regulated kinase 1A SINGLE PROTEIN Q13627

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000157540
Ensembl ENSG00000157540
GO Cellular Component GO:0016607 (nuclear speck)
GO Molecular Function GO:0004674 (protein serine/threonine kinase activity)
GO:0004715 (non-membrane spanning protein tyrosine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0043621 (protein self-association)
GO Biological Process GO:0007399 (nervous system development)
GO:0018108 (peptidyl-tyrosine phosphorylation)
GO:0046777 (protein autophosphorylation)
Wikipedia DYRK1A

Target Cross References - Protein

canSAR Q13627
CGD Mental retardation, autosomal dominant 7
Human Protein Atlas ENSG00000157540
IntAct Q13627
PharmGKB PA27545
UniProt O60769 Q13627 Q92582 Q92810 Q9UNM5

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_cat_dom.)
IPR002290 (Ser/Thr_prot_kinase_dom.)
IPR008271 (Ser/Thr_prot_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR017442 (Se/Thr_prot_kinase-like_dom.)
Pfam PF00069 (Pkinase)

Target Cross References - Structure

PDBe 2VX3 2WO6 3ANQ 3ANR
CREDO 2VX3 2WO6 3ANQ 3ANR
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