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Target Report Card

Target Name and Classification

Target ID CHEMBL2285
Target Type SINGLE PROTEIN
Preferred Name ADAMTS5
Synonyms A disintegrin and metalloproteinase with thrombospondin motifs 11 | A disintegrin and metalloproteinase with thrombospondin motifs 5 | ADAM-TS 11 | ADAM-TS 5 | ADAM-TS5 | ADAMTS-11 | ADAMTS-5 | ADAMTS11 | ADAMTS5 | ADMP-2 | ADMP2 | Aggrecanase-2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > metallo protease > metallo protease mam clan > metallo protease m12b subfamily

Target Components

Component Description Relationship Accession
A disintegrin and metalloproteinase with thrombospondin motifs 5 SINGLE PROTEIN Q9UNA0

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000154736
Ensembl ENSG00000154736
GO Cellular Component GO:0005576 (extracellular region)
GO:0005578 (proteinaceous extracellular matrix)
GO:0005615 (extracellular space)
GO:0005788 (endoplasmic reticulum lumen)
GO:0031012 (extracellular matrix)
GO Molecular Function GO:0004222 (metalloendopeptidase activity)
GO:0005178 (integrin binding)
GO:0005515 (protein binding)
GO:0008201 (heparin binding)
GO:0008233 (peptidase activity)
GO:0008237 (metallopeptidase activity)
GO:0008270 (zinc ion binding)
GO:0016787 (hydrolase activity)
GO:0046872 (metal ion binding)
GO:0050840 (extracellular matrix binding)
GO Biological Process GO:0006508 (proteolysis)
GO:0022617 (extracellular matrix disassembly)
GO:0036066 (protein O-linked fucosylation)
GO:0042742 (defense response to bacterium)
Wikipedia ADAMTS5

Target Cross References - Protein

Human Protein Atlas ENSG00000154736
IntAct Q9UNA0
Guide to Pharmacology 1678
Open Targets ENSG00000154736
Reactome R-HSA-1474228 (Degradation of the extracellular matrix.)
R-HSA-5083635 (Defective B3GALTL causes Peters-plus syndrome (PpS).)
R-HSA-5173214 (O-glycosylation of TSR domain-containing proteins.)
UniProt Q52LV4 Q9UKP2 Q9UNA0

Target Cross References - Domain

InterPro IPR000884 (TSP1_rpt.)
IPR001590 (Peptidase_M12B.)
IPR002870 (Peptidase_M12B_N.)
IPR006586 (ADAM_Cys-rich.)
IPR010294 (ADAM_spacer1.)
IPR013273 (Peptidase_M12B_ADAM-TS.)
IPR013276 (Pept_M12B_ADAM-TS5.)
IPR024079 (MetalloPept_cat_dom.)
Pfam PF00090 (TSP_1)
PF01421 (Reprolysin)
PF01562 (Pep_M12B_propep)
PF05986 (ADAM_spacer1)

Target Cross References - Structure

PDBe 2RJQ 3B8Z 3HY7 3HY9 3HYG 3LJT
CREDO 2RJQ 3B8Z 3HY7 3HY9 3HYG 3LJT
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