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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2284
Target Type SINGLE PROTEIN
Preferred Name Glyceraldehyde-3-phosphate dehydrogenase liver
Synonyms GAPD | GAPDH | GAPDH | Glyceraldehyde-3-phosphate dehydrogenase | OK/SW-cl.12 | Peptidyl-cysteine S-nitrosylase GAPDH
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Glyceraldehyde-3-phosphate dehydrogenase SINGLE PROTEIN P04406

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000111640
Ensembl ENSG00000111640
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005811 (lipid particle)
GO:0005829 (cytosol)
GO:0005856 (cytoskeleton)
GO:0005886 (plasma membrane)
GO:0015630 (microtubule cytoskeleton)
GO:0016020 (membrane)
GO:0030529 (intracellular ribonucleoprotein complex)
GO:0031012 (extracellular matrix)
GO:0031965 (nuclear membrane)
GO:0031982 (vesicle)
GO:0043231 (intracellular membrane-bounded organelle)
GO:0048471 (perinuclear region of cytoplasm)
GO:0070062 (extracellular exosome)
GO:0097452 (GAIT complex)
GO Molecular Function GO:0004365 (glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity)
GO:0005515 (protein binding)
GO:0008017 (microtubule binding)
GO:0016491 (oxidoreductase activity)
GO:0016620 (oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor)
GO:0016740 (transferase activity)
GO:0035605 (peptidyl-cysteine S-nitrosylase activity)
GO:0042802 (identical protein binding)
GO:0050661 (NADP binding)
GO:0051287 (NAD binding)
GO Biological Process GO:0000226 (microtubule cytoskeleton organization)
GO:0006006 (glucose metabolic process)
GO:0006094 (gluconeogenesis)
GO:0006096 (glycolytic process)
GO:0006417 (regulation of translation)
GO:0006915 (apoptotic process)
GO:0016241 (regulation of macroautophagy)
GO:0017148 (negative regulation of translation)
GO:0035606 (peptidyl-cysteine S-trans-nitrosylation)
GO:0050821 (protein stabilization)
GO:0051402 (neuron apoptotic process)
GO:0055114 (oxidation-reduction process)
GO:0061621 (canonical glycolysis)
GO:0071346 (cellular response to interferon-gamma)
Wikipedia Glyceraldehyde_3-phosphate_dehydrogenase

Target Cross References - Protein

canSAR P04406
Human Protein Atlas ENSG00000111640
IntAct P04406
Open Targets ENSG00000111640
PharmGKB PA28554
Reactome R-HSA-70171 (Glycolysis.)
R-HSA-70263 (Gluconeogenesis.)
UniProt E7EUT4 P00354 P04406 Q53X65

Target Cross References - Domain

InterPro IPR006424 (Glyceraldehyde-3-P_DH_1.)
IPR016040 (NAD(P)-bd_dom.)
IPR020828 (GlycerAld_3-P_DH_NAD(P)-bd.)
IPR020829 (GlycerAld_3-P_DH_cat.)
IPR020830 (GlycerAld_3-P_DH_AS.)
IPR020831 (GlycerAld/Erythrose_P_DH.)
Pfam PF00044 (Gp_dh_N)
PF02800 (Gp_dh_C)

Target Cross References - Structure

PDBe 1U8F 1ZNQ 3GPD 4WNC 4WNI
CREDO 1U8F 1ZNQ 3GPD 4WNC 4WNI
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