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Target Report Card

Target Name and Classification

Target ID CHEMBL2282
Preferred Name Glucose-6-phosphatase
Synonyms G-6-Pase | G6PC | G6PT | G6Pase | G6Pase-alpha | Glucose-6-phosphatase alpha | Glucose-6-phosphatase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Glucose-6-phosphatase SINGLE PROTEIN P35575

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000131482
Ensembl ENSG00000131482
GO Cellular Component GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030176 (integral component of endoplasmic reticulum membrane)
GO:0043231 (intracellular membrane-bounded organelle)
GO Molecular Function GO:0004346 (glucose-6-phosphatase activity)
GO:0016773 (phosphotransferase activity, alcohol group as acceptor)
GO:0016787 (hydrolase activity)
GO:0042301 (phosphate ion binding)
GO Biological Process GO:0005977 (glycogen metabolic process)
GO:0005980 (glycogen catabolic process)
GO:0006094 (gluconeogenesis)
GO:0006641 (triglyceride metabolic process)
GO:0006796 (phosphate-containing compound metabolic process)
GO:0008202 (steroid metabolic process)
GO:0010468 (regulation of gene expression)
GO:0015760 (glucose-6-phosphate transport)
GO:0032094 (response to food)
GO:0035264 (multicellular organism growth)
GO:0042593 (glucose homeostasis)
GO:0042632 (cholesterol homeostasis)
GO:0046415 (urate metabolic process)
GO:0046838 (phosphorylated carbohydrate dephosphorylation)
GO:0051156 (glucose 6-phosphate metabolic process)
GO:0055088 (lipid homeostasis)
Wikipedia G6PC

Target Cross References - Protein

canSAR P35575
CGD Glycogen storage disease Ia
Human Protein Atlas ENSG00000131482
IntAct P35575
Open Targets ENSG00000131482
PharmGKB PA28468
Reactome R-HSA-3274531 (Glycogen storage disease type Ia (G6PC).)
R-HSA-70263 (Gluconeogenesis.)
UniProt A1L4C0 B4E1C3 K7EL82 P35575

Target Cross References - Domain

InterPro IPR000326 (P_Acid_Pase_2/haloperoxidase.)
IPR016275 (Glucose-6-phosphatase.)
IPR036938 (P_Acid_Pase_2/haloperoxi_sf.)
Pfam PF01569 (PAP2)