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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2259
Target Type SINGLE PROTEIN
Preferred Name Vitamin D-binding protein
Synonyms DBP | DBP-maf | GC | Gc protein-derived macrophage activating factor | Gc | Gc-MAF | Gc-globulin | GcMAF | Group-specific component | VDB | Vitamin D-binding protein | Vitamin D-binding protein-macrophage activating factor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • secreted protein

Target Components

Component Description Relationship Accession
Vitamin D-binding protein SINGLE PROTEIN P02774

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000145321
Ensembl ENSG00000145321
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005829 (cytosol)
GO:0030424 (axon)
GO:0043202 (lysosomal lumen)
GO:0048471 (perinuclear region of cytoplasm)
GO:0070062 (extracellular exosome)
GO:0072562 (blood microparticle)
GO Molecular Function GO:0003779 (actin binding)
GO:0005499 (vitamin D binding)
GO:0051183 (vitamin transporter activity)
GO:1902118 (calcidiol binding)
GO Biological Process GO:0006810 (transport)
GO:0007565 (female pregnancy)
GO:0007595 (lactation)
GO:0031667 (response to nutrient levels)
GO:0032355 (response to estradiol)
GO:0042359 (vitamin D metabolic process)
GO:0048545 (response to steroid hormone)
GO:0051180 (vitamin transport)
Wikipedia Vitamin_D-binding_protein

Target Cross References - Protein

canSAR P02774
Human Protein Atlas ENSG00000145321
IntAct P02774
Open Targets ENSG00000145321
PharmGKB PA28601
Reactome R-HSA-196791 (Vitamin D (calciferol) metabolism.)
UniProt B4DPP2 D6RAK8 P02774 Q16309 Q16310 Q53F31 Q6GTG1

Target Cross References - Domain

InterPro IPR000213 (VitD-bd.)
IPR000264 (ALB/AFP/VDB.)
IPR014760 (Serum_albumin_N.)
IPR015247 (VitD-bind_III.)
IPR020857 (Serum_albumin_CS.)
IPR020858 (Serum_albumin-like.)
Pfam PF00273 (Serum_albumin)
PF09164 (VitD-bind_III)

Target Cross References - Structure

PDBe 1J78 1J7E 1KW2 1KXP 1LOT 1MA9
CREDO 1J78 1J7E 1KW2 1KXP 1LOT 1MA9
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