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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2250
Target Type SINGLE PROTEIN
Preferred Name Tyrosine-protein kinase BLK
Synonyms B lymphocyte kinase | BLK | Tyrosine-protein kinase Blk | p55-Blk
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase src family

Target Components

Component Description Relationship Accession
Tyrosine-protein kinase Blk SINGLE PROTEIN P51451

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2363074 SRC PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000136573
Ensembl ENSG00000136573
GO Cellular Component GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0031234 (extrinsic component of cytoplasmic side of plasma membrane)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004713 (protein tyrosine kinase activity)
GO:0004715 (non-membrane spanning protein tyrosine kinase activity)
GO:0005102 (receptor binding)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO Biological Process GO:0006468 (protein phosphorylation)
GO:0007010 (cytoskeleton organization)
GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway)
GO:0016310 (phosphorylation)
GO:0030154 (cell differentiation)
GO:0032024 (positive regulation of insulin secretion)
GO:0035556 (intracellular signal transduction)
GO:0038083 (peptidyl-tyrosine autophosphorylation)
GO:0042127 (regulation of cell proliferation)
GO:0043066 (negative regulation of apoptotic process)
GO:0045087 (innate immune response)
GO:0050764 (regulation of phagocytosis)
GO:0050853 (B cell receptor signaling pathway)
GO:0071801 (regulation of podosome assembly)
Wikipedia Tyrosine-protein_kinase_BLK

Target Cross References - Protein

canSAR P51451
CGD Maturity-onset diabetes of the young, type 11
Human Protein Atlas ENSG00000136573
IntAct P51451
Guide to Pharmacology 1940
Open Targets ENSG00000136573
PharmGKB PA25368
Pharos P51451 (Tchem)
Reactome R-HSA-983695 (Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.)
UniProt P51451 Q16291 Q96IN1

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR000980 (SH2.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR001452 (SH3_domain.)
IPR011009 (Kinase-like_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020635 (Tyr_kinase_cat_dom.)
Pfam PF00017 (SH2)
PF00018 (SH3_1)
PF07714 (Pkinase_Tyr)
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