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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2250
Preferred Name Tyrosine-protein kinase BLK
Synonyms B lymphocyte kinase | BLK | Tyrosine-protein kinase Blk | p55-Blk
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase src family

Target Components

Component Description Relationship Accession
Tyrosine-protein kinase Blk SINGLE PROTEIN P51451

Target Relations

ChEMBL ID Pref Name Target Type

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000136573
Ensembl ENSG00000136573
GO Cellular Component GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0031234 (extrinsic component of cytoplasmic side of plasma membrane)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004713 (protein tyrosine kinase activity)
GO:0004715 (non-membrane spanning protein tyrosine kinase activity)
GO:0005102 (receptor binding)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO Biological Process GO:0006468 (protein phosphorylation)
GO:0007010 (cytoskeleton organization)
GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway)
GO:0016310 (phosphorylation)
GO:0030154 (cell differentiation)
GO:0032024 (positive regulation of insulin secretion)
GO:0035556 (intracellular signal transduction)
GO:0038083 (peptidyl-tyrosine autophosphorylation)
GO:0042127 (regulation of cell proliferation)
GO:0043066 (negative regulation of apoptotic process)
GO:0045087 (innate immune response)
GO:0050764 (regulation of phagocytosis)
GO:0050853 (B cell receptor signaling pathway)
GO:0071801 (regulation of podosome assembly)
Wikipedia Tyrosine-protein_kinase_BLK

Target Cross References - Protein

canSAR P51451
CGD Maturity-onset diabetes of the young, type 11
Human Protein Atlas ENSG00000136573
IntAct P51451
Guide to Pharmacology 1940
Open Targets ENSG00000136573
PharmGKB PA25368
Pharos P51451 (Tchem)
Reactome R-HSA-983695 (Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.)
UniProt P51451 Q16291 Q96IN1

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR000980 (SH2.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR001452 (SH3_domain.)
IPR011009 (Kinase-like_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020635 (Tyr_kinase_cat_dom.)
Pfam PF00017 (SH2)
PF00018 (SH3_1)
PF07714 (Pkinase_Tyr)