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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL225
Target Type SINGLE PROTEIN
Preferred Name Serotonin 2c (5-HT2c) receptor
Synonyms 5-HT-1C | 5-HT-2C | 5-HT1C | 5-HT2C | 5-HTR2C | 5-hydroxytryptamine receptor 1C | 5-hydroxytryptamine receptor 2C | HTR1C | HTR2C | Serotonin receptor 2C
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > monoamine receptor > serotonin receptor

Target Components

Component Description Relationship Accession
5-hydroxytryptamine receptor 2C SINGLE PROTEIN P28335

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2096662 Serotonin 2 receptors; 5-HT2a & 5-HT2c SELECTIVITY GROUP
CHEMBL2111466 Serotonin receptor (2b and 2c) SELECTIVITY GROUP
CHEMBL2095200 Serotonin 2 (5-HT2) receptor PROTEIN FAMILY
CHEMBL2096904 Serotonin (5-HT) receptor PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL479 THIORIDAZINE Serotonin 2c (5-HT2c) receptor antagonist 4 DailyMed DailyMed ISBN
CHEMBL85 RISPERIDONE Serotonin 2c (5-HT2c) receptor antagonist 4 DailyMed FDA
CHEMBL654 MIRTAZAPINE Serotonin 2c (5-HT2c) receptor antagonist 4 DailyMed
CHEMBL715 OLANZAPINE Serotonin 2c (5-HT2c) receptor antagonist 4 DailyMed FDA
CHEMBL831 LOXAPINE Serotonin 2c (5-HT2c) receptor antagonist 4 DailyMed FDA
CHEMBL908 CHLORPROTHIXENE Serotonin 2c (5-HT2c) receptor antagonist 4 PubMed PubMed
CHEMBL1710 TRIFLUOPERAZINE HYDROCHLORIDE Serotonin 2c (5-HT2c) receptor antagonist 4 ISBN
CHEMBL1712 ZIPRASIDONE HYDROCHLORIDE Serotonin 2c (5-HT2c) receptor antagonist 4 DailyMed
CHEMBL1200426 METHIXENE HYDROCHLORIDE Serotonin 2c (5-HT2c) receptor antagonist 4 ISBN PubMed
CHEMBL1200492 NEFAZODONE HYDROCHLORIDE Serotonin 2c (5-HT2c) receptor antagonist 4 DailyMed
CHEMBL1200636 CYCLOBENZAPRINE HYDROCHLORIDE Serotonin 2c (5-HT2c) receptor antagonist 4 PubMed
CHEMBL1200798 TRAZODONE HYDROCHLORIDE Serotonin 2c (5-HT2c) receptor antagonist 4 DailyMed FDA
CHEMBL1200911 QUETIAPINE FUMARATE Serotonin 2c (5-HT2c) receptor antagonist 4 DailyMed
CHEMBL1200916 THIORIDAZINE HYDROCHLORIDE Serotonin 2c (5-HT2c) receptor antagonist 4 DailyMed DailyMed ISBN
CHEMBL1200938 METHYSERGIDE MALEATE Serotonin 2c (5-HT2c) receptor antagonist 4 ISBN
CHEMBL1200948 TRIMIPRAMINE MALEATE Serotonin 2c (5-HT2c) receptor antagonist 4 ISBN PubMed
CHEMBL1200997 ZIPRASIDONE MESYLATE Serotonin 2c (5-HT2c) receptor antagonist 4 DailyMed
CHEMBL1201060 LOXAPINE HYDROCHLORIDE Serotonin 2c (5-HT2c) receptor antagonist 4 DailyMed FDA
CHEMBL1201155 LOXAPINE SUCCINATE Serotonin 2c (5-HT2c) receptor antagonist 4 DailyMed FDA
CHEMBL1201741 OLANZAPINE PAMOATE Serotonin 2c (5-HT2c) receptor antagonist 4 FDA
CHEMBL2095211 LORCASERIN HYDROCHLORIDE Serotonin 2c (5-HT2c) receptor agonist 4 Expert
CHEMBL2358147 CARPHENAZINE MALEATE Serotonin 2c (5-HT2c) receptor antagonist 4 ISBN PubMed
CHEMBL2107339 ESMIRTAZAPINE MALEATE Serotonin 2c (5-HT2c) receptor antagonist 3 PubMed PubMed
CHEMBL2104986 TEDATIOXETINE Serotonin 2c (5-HT2c) receptor antagonist 2 Other Other
CHEMBL2104991 VABICASERIN HYDROCHLORIDE Serotonin 2c (5-HT2c) receptor agonist 2 PubMed
More...

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000147246
Ensembl ENSG00000147246
GO Cellular Component GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0001587 (Gq/11-coupled serotonin receptor activity)
GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004993 (G-protein coupled serotonin receptor activity)
GO:0008144 (drug binding)
GO:0051378 (serotonin binding)
GO:0071886 (1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding)
GO Biological Process GO:0001662 (behavioral fear response)
GO:0006182 (cGMP biosynthetic process)
GO:0006874 (cellular calcium ion homeostasis)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007200 (phospholipase C-activating G-protein coupled receptor signaling pathway)
GO:0007208 (phospholipase C-activating serotonin receptor signaling pathway)
GO:0007210 (serotonin receptor signaling pathway)
GO:0007268 (chemical synaptic transmission)
GO:0007610 (behavior)
GO:0007626 (locomotory behavior)
GO:0007631 (feeding behavior)
GO:0010513 (positive regulation of phosphatidylinositol biosynthetic process)
GO:0031644 (regulation of neurological system process)
GO:0032098 (regulation of appetite)
GO:0042493 (response to drug)
GO:0043397 (regulation of corticotropin-releasing hormone secretion)
GO:0045600 (positive regulation of fat cell differentiation)
GO:0051209 (release of sequestered calcium ion into cytosol)
GO:0051482 (positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway)
GO:0070374 (positive regulation of ERK1 and ERK2 cascade)
Wikipedia 5-HT2C_receptor

Target Cross References - Protein

canSAR P28335
Human Protein Atlas ENSG00000147246
IntAct P28335
Guide to Pharmacology 8
Open Targets ENSG00000147246
PharmGKB PA194
Pharos P28335 (Tclin)
Reactome R-HSA-390666 (Serotonin receptors.)
R-HSA-416476 (G alpha (q) signalling events.)
UniProt B1AMW4 P28335 Q5VUF8 Q9NP28

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000377 (5HT2C_rcpt.)
IPR002231 (5HT_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)
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