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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2246
Target Type SINGLE PROTEIN
Preferred Name Aldehyde reductase
Synonyms AKR1A1 | ALDR1 | ALR | Alcohol dehydrogenase [NADP(+)] | Aldehyde reductase | Aldo-keto reductase family 1 member A1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Alcohol dehydrogenase [NADP(+)] SINGLE PROTEIN P14550

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000117448
Ensembl ENSG00000117448
GO Cellular Component GO:0005615 (extracellular space)
GO:0005829 (cytosol)
GO:0016324 (apical plasma membrane)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0004032 (alditol:NADP+ 1-oxidoreductase activity)
GO:0004033 (aldo-keto reductase (NADP) activity)
GO:0005515 (protein binding)
GO:0008106 (alcohol dehydrogenase (NADP+) activity)
GO:0009055 (electron carrier activity)
GO:0016491 (oxidoreductase activity)
GO:0047939 (L-glucuronate reductase activity)
GO Biological Process GO:0006006 (glucose metabolic process)
GO:0006081 (cellular aldehyde metabolic process)
GO:0019640 (glucuronate catabolic process to xylulose 5-phosphate)
GO:0019853 (L-ascorbic acid biosynthetic process)
GO:0042840 (D-glucuronate catabolic process)
GO:0046185 (aldehyde catabolic process)
GO:0055114 (oxidation-reduction process)
GO:1901687 (glutathione derivative biosynthetic process)
Wikipedia Aldo-keto_reductase_family_1,_member_A1

Target Cross References - Protein

canSAR P14550
Human Protein Atlas ENSG00000117448
IntAct P14550
Open Targets ENSG00000117448
PharmGKB PA24674
Reactome R-HSA-156590 (Glutathione conjugation.)
R-HSA-5661270 (Catabolism of glucuronate to xylulose-5-phosphate.)
UniProt A8KAL8 D3DQ04 P14550 Q6IAZ4

Target Cross References - Domain

InterPro IPR018170 (Aldo/ket_reductase_CS.)
IPR020471 (Aldo/keto_reductase.)
IPR023210 (NADP_OxRdtase_dom.)
Pfam PF00248 (Aldo_ket_red)

Target Cross References - Structure

PDBe 2ALR
CREDO 2ALR
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