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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2242
Target Type SINGLE PROTEIN
Preferred Name Glutathione S-transferase Mu 3
Synonyms GST class-mu 3 | GST5 | GSTM3 | GSTM3-3 | Glutathione S-transferase Mu 3 | hGSTM3-3
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Glutathione S-transferase Mu 3 SINGLE PROTEIN P21266

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000134202
Ensembl ENSG00000134202
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0035686 (sperm fibrous sheath)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0004364 (glutathione transferase activity)
GO:0016740 (transferase activity)
GO:0019899 (enzyme binding)
GO:0042802 (identical protein binding)
GO:0042803 (protein homodimerization activity)
GO:0043295 (glutathione binding)
GO Biological Process GO:0006749 (glutathione metabolic process)
GO:0008065 (establishment of blood-nerve barrier)
GO:0008152 (metabolic process)
GO:0018916 (nitrobenzene metabolic process)
GO:0042178 (xenobiotic catabolic process)
GO:0043627 (response to estrogen)
GO:0070458 (cellular detoxification of nitrogen compound)
GO:1901687 (glutathione derivative biosynthetic process)
Wikipedia GSTM3

Target Cross References - Protein

canSAR P21266
Human Protein Atlas ENSG00000134202
IntAct P21266
Open Targets ENSG00000134202
PharmGKB PA29024
Reactome R-HSA-156590 (Glutathione conjugation.)
UniProt O60550 P21266 Q96HA3

Target Cross References - Domain

InterPro IPR003081 (GST_mu.)
IPR004045 (Glutathione_S-Trfase_N.)
IPR004046 (GST_C.)
IPR010987 (Glutathione-S-Trfase_C-like.)
IPR012336 (Thioredoxin-like_fold.)
Pfam PF00043 (GST_C)
PF02798 (GST_N)

Target Cross References - Structure

PDBe 3GTU
CREDO 3GTU
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